On Parallel Streams through the Mouse Dorsal Lateral Geniculate Nucleus
The mouse visual system is an emerging model for the study of cortical and thalamic circuit function. To maximize the usefulness of this model system, it is important to analyze the similarities and differences between the organization of all levels of the murid visual system with other, better stud...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-03-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncir.2016.00020/full |
| _version_ | 1818109451602755584 |
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| author | Daniel eDenman Diego eContreras |
| author_facet | Daniel eDenman Diego eContreras |
| author_sort | Daniel eDenman |
| collection | DOAJ |
| description | The mouse visual system is an emerging model for the study of cortical and thalamic circuit function. To maximize the usefulness of this model system, it is important to analyze the similarities and differences between the organization of all levels of the murid visual system with other, better studied systems (e.g., non-human primates and the domestic cat). While the understanding of mouse retina and cortex has expanded rapidly, less is known about mouse dorsal lateral geniculate nucleus (dLGN). Here, we study whether parallel processing streams exist in mouse dLGN. We use a battery of stimuli that have been previously shown to successfully distinguish parallel streams in other species: electrical stimulation of the optic chiasm, contrast-reversing stationary gratings at varying spatial phase, drifting sinusoidal gratings, dense noise for receptive field reconstruction, and frozen contrast-modulating noise. As in the optic nerves of domestic cats and non-human primates, we find evidence for multiple conduction velocity groups after optic chiasm stimulation. As in so-called ‘visual mammals’, we find a subpopulation of mouse dLGN cells showing non-linear spatial summation. However, differences in stimulus selectivity and sensitivity do not provide sufficient basis for identification of clearly distinct classes of relay cells. Nevertheless, consistent with presumptively homologous status of dLGNs of all mammals, there are substantial similarities between response properties of mouse dLGN neurons and those of cats and primates. |
| first_indexed | 2024-12-11T02:31:28Z |
| format | Article |
| id | doaj.art-e3bd03c7d6b2499da2b1caa598a7137a |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-11T02:31:28Z |
| publishDate | 2016-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-e3bd03c7d6b2499da2b1caa598a7137a2022-12-22T01:23:49ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102016-03-011010.3389/fncir.2016.00020178141On Parallel Streams through the Mouse Dorsal Lateral Geniculate NucleusDaniel eDenman0Diego eContreras1Allen Institute for Brain SciencePerelman School of Medicine, University of PennsylvaniaThe mouse visual system is an emerging model for the study of cortical and thalamic circuit function. To maximize the usefulness of this model system, it is important to analyze the similarities and differences between the organization of all levels of the murid visual system with other, better studied systems (e.g., non-human primates and the domestic cat). While the understanding of mouse retina and cortex has expanded rapidly, less is known about mouse dorsal lateral geniculate nucleus (dLGN). Here, we study whether parallel processing streams exist in mouse dLGN. We use a battery of stimuli that have been previously shown to successfully distinguish parallel streams in other species: electrical stimulation of the optic chiasm, contrast-reversing stationary gratings at varying spatial phase, drifting sinusoidal gratings, dense noise for receptive field reconstruction, and frozen contrast-modulating noise. As in the optic nerves of domestic cats and non-human primates, we find evidence for multiple conduction velocity groups after optic chiasm stimulation. As in so-called ‘visual mammals’, we find a subpopulation of mouse dLGN cells showing non-linear spatial summation. However, differences in stimulus selectivity and sensitivity do not provide sufficient basis for identification of clearly distinct classes of relay cells. Nevertheless, consistent with presumptively homologous status of dLGNs of all mammals, there are substantial similarities between response properties of mouse dLGN neurons and those of cats and primates.http://journal.frontiersin.org/Journal/10.3389/fncir.2016.00020/fullmouse modelsLGNcell typesparallel processingmouse vision |
| spellingShingle | Daniel eDenman Diego eContreras On Parallel Streams through the Mouse Dorsal Lateral Geniculate Nucleus Frontiers in Neural Circuits mouse models LGN cell types parallel processing mouse vision |
| title | On Parallel Streams through the Mouse Dorsal Lateral Geniculate Nucleus |
| title_full | On Parallel Streams through the Mouse Dorsal Lateral Geniculate Nucleus |
| title_fullStr | On Parallel Streams through the Mouse Dorsal Lateral Geniculate Nucleus |
| title_full_unstemmed | On Parallel Streams through the Mouse Dorsal Lateral Geniculate Nucleus |
| title_short | On Parallel Streams through the Mouse Dorsal Lateral Geniculate Nucleus |
| title_sort | on parallel streams through the mouse dorsal lateral geniculate nucleus |
| topic | mouse models LGN cell types parallel processing mouse vision |
| url | http://journal.frontiersin.org/Journal/10.3389/fncir.2016.00020/full |
| work_keys_str_mv | AT danieledenman onparallelstreamsthroughthemousedorsallateralgeniculatenucleus AT diegoecontreras onparallelstreamsthroughthemousedorsallateralgeniculatenucleus |