Human Trial for the Effect of Plasma-Activated Water Spray on Vaginal Cleaning in Patients with Bacterial Vaginosis
Underwater plasma discharge temporally produces several reactive radicals and/or free chlorine molecules in water, which is responsible for antimicrobial activity. Hence, it can simply sanitize tap water without disinfectant treatment. Additionally, the spraying technique using cleaning water exploi...
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MDPI AG
2022-06-01
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| Series: | Medical Sciences |
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| Online Access: | https://www.mdpi.com/2076-3271/10/2/33 |
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| author | Yongwoo Jang Junsoo Bok Dong Keun Ahn Chang-Koo Kim Ju-Seop Kang |
| author_facet | Yongwoo Jang Junsoo Bok Dong Keun Ahn Chang-Koo Kim Ju-Seop Kang |
| author_sort | Yongwoo Jang |
| collection | DOAJ |
| description | Underwater plasma discharge temporally produces several reactive radicals and/or free chlorine molecules in water, which is responsible for antimicrobial activity. Hence, it can simply sanitize tap water without disinfectant treatment. Additionally, the spraying technique using cleaning water exploits deep application in the narrow and curved vaginal tract of patients. Herein, we attempted a clinical trial to evaluate the vaginal cleaning effect of spraying plasma-activated water (PAW) to patients with vaginitis (46 patients). The efficacy was compared with treatment with betadine antiseptics used to treat bacterial vaginosis (40 patients). To evaluate the cleaning effect, Gram staining of the vaginal secretions was conducted before and after spraying PAW or betadine treatment (BT). Consequently, PAW-sprayed (PAWS) patients (22.3%) showed a better vaginal cleaning effect against Gram-positive and -negative bacteria than BT patients (14.4%). Moreover, 18 patients in the BT group showed worsened vaginal contamination, whereas five patients in the PAWS group showed worsened vaginal contamination. Taken together, the noncontact method of spraying cleaning water to the vagina exhibited a reliable vaginal cleaning effect without further bacterial infection compared with BT. Therefore, we suggest a clinical application of the spraying method using PAW for vaginal cleaning to patients with vaginitis without disinfectants and antibiotics. |
| first_indexed | 2024-03-09T23:06:20Z |
| format | Article |
| id | doaj.art-e3bd132755d4444cb4e63d1d8b6a2378 |
| institution | Directory Open Access Journal |
| issn | 2076-3271 |
| language | English |
| last_indexed | 2024-03-09T23:06:20Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences |
| spelling | doaj.art-e3bd132755d4444cb4e63d1d8b6a23782023-11-23T17:53:39ZengMDPI AGMedical Sciences2076-32712022-06-011023310.3390/medsci10020033Human Trial for the Effect of Plasma-Activated Water Spray on Vaginal Cleaning in Patients with Bacterial VaginosisYongwoo Jang0Junsoo Bok1Dong Keun Ahn2Chang-Koo Kim3Ju-Seop Kang4Department of Pharmacology, College of Medicine, Hanyang University, Seoul 04736, KoreaDepartment of Biomedical Engineering, Hanyang University, Seoul 04736, KoreaDepartment of Media Communication, Hanyang University, Seoul 04736, KoreaDepartment of Chemical Engineering and Department of Energy Systems Research, Ajou University, Suwon 16499, KoreaDepartment of Pharmacology, College of Medicine, Hanyang University, Seoul 04736, KoreaUnderwater plasma discharge temporally produces several reactive radicals and/or free chlorine molecules in water, which is responsible for antimicrobial activity. Hence, it can simply sanitize tap water without disinfectant treatment. Additionally, the spraying technique using cleaning water exploits deep application in the narrow and curved vaginal tract of patients. Herein, we attempted a clinical trial to evaluate the vaginal cleaning effect of spraying plasma-activated water (PAW) to patients with vaginitis (46 patients). The efficacy was compared with treatment with betadine antiseptics used to treat bacterial vaginosis (40 patients). To evaluate the cleaning effect, Gram staining of the vaginal secretions was conducted before and after spraying PAW or betadine treatment (BT). Consequently, PAW-sprayed (PAWS) patients (22.3%) showed a better vaginal cleaning effect against Gram-positive and -negative bacteria than BT patients (14.4%). Moreover, 18 patients in the BT group showed worsened vaginal contamination, whereas five patients in the PAWS group showed worsened vaginal contamination. Taken together, the noncontact method of spraying cleaning water to the vagina exhibited a reliable vaginal cleaning effect without further bacterial infection compared with BT. Therefore, we suggest a clinical application of the spraying method using PAW for vaginal cleaning to patients with vaginitis without disinfectants and antibiotics.https://www.mdpi.com/2076-3271/10/2/33plasma-activated waterunderwater plasma dischargebacterial vaginosisvaginal cleaning |
| spellingShingle | Yongwoo Jang Junsoo Bok Dong Keun Ahn Chang-Koo Kim Ju-Seop Kang Human Trial for the Effect of Plasma-Activated Water Spray on Vaginal Cleaning in Patients with Bacterial Vaginosis Medical Sciences plasma-activated water underwater plasma discharge bacterial vaginosis vaginal cleaning |
| title | Human Trial for the Effect of Plasma-Activated Water Spray on Vaginal Cleaning in Patients with Bacterial Vaginosis |
| title_full | Human Trial for the Effect of Plasma-Activated Water Spray on Vaginal Cleaning in Patients with Bacterial Vaginosis |
| title_fullStr | Human Trial for the Effect of Plasma-Activated Water Spray on Vaginal Cleaning in Patients with Bacterial Vaginosis |
| title_full_unstemmed | Human Trial for the Effect of Plasma-Activated Water Spray on Vaginal Cleaning in Patients with Bacterial Vaginosis |
| title_short | Human Trial for the Effect of Plasma-Activated Water Spray on Vaginal Cleaning in Patients with Bacterial Vaginosis |
| title_sort | human trial for the effect of plasma activated water spray on vaginal cleaning in patients with bacterial vaginosis |
| topic | plasma-activated water underwater plasma discharge bacterial vaginosis vaginal cleaning |
| url | https://www.mdpi.com/2076-3271/10/2/33 |
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