Duration of Neonatal Antibiotic Exposure in Preterm Infants in Association with Health and Developmental Outcomes in Early Childhood
Over 90% of preterm neonates are, often empirically, exposed to antibiotics as a potentially life-saving measure against sepsis. Long-term outcome in association with antibiotic exposure (NABE) has insufficiently been studied after preterm birth. We investigated the association of NABE-duration with...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/12/6/967 |
| _version_ | 1797596423775059968 |
|---|---|
| author | Nancy Deianova Nanne K. de Boer Hafsa Aoulad Ahajan Cilla Verbeek Cornelieke S. H. Aarnoudse-Moens Aleid G. Leemhuis Mirjam M. van Weissenbruch Anton H. van Kaam Daniel C. Vijbrief Chris V. Hulzebos Astrid Giezen Veerle Cossey Willem P. de Boode Wouter J. de Jonge Marc A. Benninga Hendrik J. Niemarkt Tim G. J. de Meij |
| author_facet | Nancy Deianova Nanne K. de Boer Hafsa Aoulad Ahajan Cilla Verbeek Cornelieke S. H. Aarnoudse-Moens Aleid G. Leemhuis Mirjam M. van Weissenbruch Anton H. van Kaam Daniel C. Vijbrief Chris V. Hulzebos Astrid Giezen Veerle Cossey Willem P. de Boode Wouter J. de Jonge Marc A. Benninga Hendrik J. Niemarkt Tim G. J. de Meij |
| author_sort | Nancy Deianova |
| collection | DOAJ |
| description | Over 90% of preterm neonates are, often empirically, exposed to antibiotics as a potentially life-saving measure against sepsis. Long-term outcome in association with antibiotic exposure (NABE) has insufficiently been studied after preterm birth. We investigated the association of NABE-duration with early-childhood developmental and health outcomes in preterm-born children and additionally assessed the impact of GA on outcomes. Preterm children (GA < 30 weeks) participating in a multicenter cohort study were approached for follow-up. General expert-reviewed health questionnaires on respiratory, atopic and gastrointestinal symptoms were sent to parents of children > 24 months’ corrected age (CA). Growth and developmental assessments (Bayley Scales of Infant and Toddler Development (BSID) III) were part of standard care assessment at 24 months’ CA. Uni- and multivariate regressions were performed with NABE (per 5 days) and GA (per week) as independent variables. Odds ratios (OR) for health outcomes were adjusted (aOR) for confounders, where appropriate. Of 1079 infants whose parents were approached, 347 (32%) responded at a mean age of 4.6 years (SD 0.9). In children with NABE (97%), NABE duration decreased by 1.6 days (<i>p</i> < 0.001) per week of gestation. Below-average gross-motor development (BSID-III gross-motor score < 8) was associated with duration of NABE (aOR = 1.28; <i>p</i> = 0.04). The aOR for constipation was 0.81 (<i>p</i> = 0.04) per gestational week. Growth was inversely correlated with GA. Respiratory and atopic symptoms were not associated with NABE, nor GA. We observed that prolonged NABE after preterm birth was associated with below-average gross-motor development at 24 months’ CA, while a low GA was associated with lower weight and stature Z-scores and higher odds for constipation. |
| first_indexed | 2024-03-11T02:51:12Z |
| format | Article |
| id | doaj.art-e3bd6e38236d484fb1e37eefad9d1581 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T02:51:12Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-e3bd6e38236d484fb1e37eefad9d15812023-11-18T09:00:11ZengMDPI AGAntibiotics2079-63822023-05-0112696710.3390/antibiotics12060967Duration of Neonatal Antibiotic Exposure in Preterm Infants in Association with Health and Developmental Outcomes in Early ChildhoodNancy Deianova0Nanne K. de Boer1Hafsa Aoulad Ahajan2Cilla Verbeek3Cornelieke S. H. Aarnoudse-Moens4Aleid G. Leemhuis5Mirjam M. van Weissenbruch6Anton H. van Kaam7Daniel C. Vijbrief8Chris V. Hulzebos9Astrid Giezen10Veerle Cossey11Willem P. de Boode12Wouter J. de Jonge13Marc A. Benninga14Hendrik J. Niemarkt15Tim G. J. de Meij16Department of Pediatric Gastroenterology, Emma Children’s Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam UMC, 1105 AZ Amsterdam, The NetherlandsDepartment of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, 1105 AZ Amsterdam, The NetherlandsDepartment of Pediatric Gastroenterology, Emma Children’s Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam UMC, 1105 AZ Amsterdam, The NetherlandsDepartment of Pediatric Gastroenterology, Emma Children’s Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam UMC, 1105 AZ Amsterdam, The NetherlandsDepartment of Neonatology, Emma Children’s Hospital, Amsterdam Reproduction and Development Research Institute, 1105 AZ Amsterdam, The NetherlandsDepartment of Neonatology, Emma Children’s Hospital, Amsterdam Reproduction and Development Research Institute, 1105 AZ Amsterdam, The NetherlandsDepartment of Neonatology, Emma Children’s Hospital, Amsterdam Reproduction and Development Research Institute, 1105 AZ Amsterdam, The NetherlandsDepartment of Neonatology, Emma Children’s Hospital, Amsterdam Reproduction and Development Research Institute, 1105 AZ Amsterdam, The NetherlandsDepartment of Neonatology, University Medical Center Utrecht, Wilhelmina Children’s Hospital, 3584 CX Utrecht, The NetherlandsDepartment of Neonatology, Beatrix Children’s Hospital, University Medical Center Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Neonatology, Isala Hospital, Amalia Children’s Center, 8025 AB Zwolle, The NetherlandsDepartment of Neonatology, University Hospitals Leuven, 3000 Leuven, BelgiumDepartment of Neonatology, Radboud University Medical Center, Radboud Institute for Health Sciences, Amalia Children’s Hospital, 6525 XZ Nijmegen, The NetherlandsTytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The NetherlandsDepartment of Pediatric Gastroenterology, Emma Children’s Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam UMC, 1105 AZ Amsterdam, The NetherlandsDepartment of Neonatology, Máxima Medical Center, 5504 DB Veldhoven, The NetherlandsDepartment of Pediatric Gastroenterology, Emma Children’s Hospital, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam UMC, 1105 AZ Amsterdam, The NetherlandsOver 90% of preterm neonates are, often empirically, exposed to antibiotics as a potentially life-saving measure against sepsis. Long-term outcome in association with antibiotic exposure (NABE) has insufficiently been studied after preterm birth. We investigated the association of NABE-duration with early-childhood developmental and health outcomes in preterm-born children and additionally assessed the impact of GA on outcomes. Preterm children (GA < 30 weeks) participating in a multicenter cohort study were approached for follow-up. General expert-reviewed health questionnaires on respiratory, atopic and gastrointestinal symptoms were sent to parents of children > 24 months’ corrected age (CA). Growth and developmental assessments (Bayley Scales of Infant and Toddler Development (BSID) III) were part of standard care assessment at 24 months’ CA. Uni- and multivariate regressions were performed with NABE (per 5 days) and GA (per week) as independent variables. Odds ratios (OR) for health outcomes were adjusted (aOR) for confounders, where appropriate. Of 1079 infants whose parents were approached, 347 (32%) responded at a mean age of 4.6 years (SD 0.9). In children with NABE (97%), NABE duration decreased by 1.6 days (<i>p</i> < 0.001) per week of gestation. Below-average gross-motor development (BSID-III gross-motor score < 8) was associated with duration of NABE (aOR = 1.28; <i>p</i> = 0.04). The aOR for constipation was 0.81 (<i>p</i> = 0.04) per gestational week. Growth was inversely correlated with GA. Respiratory and atopic symptoms were not associated with NABE, nor GA. We observed that prolonged NABE after preterm birth was associated with below-average gross-motor development at 24 months’ CA, while a low GA was associated with lower weight and stature Z-scores and higher odds for constipation.https://www.mdpi.com/2079-6382/12/6/967neonatal antibiotic exposurepretermpsychomotor developmentatopypediatric constipationgrowth |
| spellingShingle | Nancy Deianova Nanne K. de Boer Hafsa Aoulad Ahajan Cilla Verbeek Cornelieke S. H. Aarnoudse-Moens Aleid G. Leemhuis Mirjam M. van Weissenbruch Anton H. van Kaam Daniel C. Vijbrief Chris V. Hulzebos Astrid Giezen Veerle Cossey Willem P. de Boode Wouter J. de Jonge Marc A. Benninga Hendrik J. Niemarkt Tim G. J. de Meij Duration of Neonatal Antibiotic Exposure in Preterm Infants in Association with Health and Developmental Outcomes in Early Childhood Antibiotics neonatal antibiotic exposure preterm psychomotor development atopy pediatric constipation growth |
| title | Duration of Neonatal Antibiotic Exposure in Preterm Infants in Association with Health and Developmental Outcomes in Early Childhood |
| title_full | Duration of Neonatal Antibiotic Exposure in Preterm Infants in Association with Health and Developmental Outcomes in Early Childhood |
| title_fullStr | Duration of Neonatal Antibiotic Exposure in Preterm Infants in Association with Health and Developmental Outcomes in Early Childhood |
| title_full_unstemmed | Duration of Neonatal Antibiotic Exposure in Preterm Infants in Association with Health and Developmental Outcomes in Early Childhood |
| title_short | Duration of Neonatal Antibiotic Exposure in Preterm Infants in Association with Health and Developmental Outcomes in Early Childhood |
| title_sort | duration of neonatal antibiotic exposure in preterm infants in association with health and developmental outcomes in early childhood |
| topic | neonatal antibiotic exposure preterm psychomotor development atopy pediatric constipation growth |
| url | https://www.mdpi.com/2079-6382/12/6/967 |
| work_keys_str_mv | AT nancydeianova durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT nannekdeboer durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT hafsaaouladahajan durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT cillaverbeek durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT corneliekeshaarnoudsemoens durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT aleidgleemhuis durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT mirjammvanweissenbruch durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT antonhvankaam durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT danielcvijbrief durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT chrisvhulzebos durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT astridgiezen durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT veerlecossey durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT willempdeboode durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT wouterjdejonge durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT marcabenninga durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT hendrikjniemarkt durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood AT timgjdemeij durationofneonatalantibioticexposureinpreterminfantsinassociationwithhealthanddevelopmentaloutcomesinearlychildhood |