The Exploration of Complement-Resistance Mechanisms of Pathogenic Gram-Negative Bacteria to Support the Development of Novel Therapeutics
Resistance to antibiotics in Bacteria is one of the biggest threats to human health. After decades of attempting to isolate or design antibiotics with novel mechanisms of action against bacterial pathogens, few approaches have been successful. Antibacterial drug discovery is now moving towards targe...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/11/8/931 |
| _version_ | 1797442911782043648 |
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| author | Marta K. Ruest Jonathan J. Dennis |
| author_facet | Marta K. Ruest Jonathan J. Dennis |
| author_sort | Marta K. Ruest |
| collection | DOAJ |
| description | Resistance to antibiotics in Bacteria is one of the biggest threats to human health. After decades of attempting to isolate or design antibiotics with novel mechanisms of action against bacterial pathogens, few approaches have been successful. Antibacterial drug discovery is now moving towards targeting bacterial virulence factors, especially immune evasion factors. Gram-negative bacteria present some of the most significant challenges in terms of antibiotic resistance. However, they are also able to be eliminated by the component of the innate immune system known as the complement system. In response, Gram-negative bacteria have evolved a variety of mechanisms by which they are able to evade complement and cause infection. Complement resistance mechanisms present some of the best novel therapeutic targets for defending against highly antibiotic-resistant pathogenic bacterial infections. |
| first_indexed | 2024-03-09T12:48:29Z |
| format | Article |
| id | doaj.art-e3bf823297a44cab9a5666ca231b5816 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T12:48:29Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-e3bf823297a44cab9a5666ca231b58162023-11-30T22:09:36ZengMDPI AGPathogens2076-08172022-08-0111893110.3390/pathogens11080931The Exploration of Complement-Resistance Mechanisms of Pathogenic Gram-Negative Bacteria to Support the Development of Novel TherapeuticsMarta K. Ruest0Jonathan J. Dennis1Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2R3, CanadaDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2R3, CanadaResistance to antibiotics in Bacteria is one of the biggest threats to human health. After decades of attempting to isolate or design antibiotics with novel mechanisms of action against bacterial pathogens, few approaches have been successful. Antibacterial drug discovery is now moving towards targeting bacterial virulence factors, especially immune evasion factors. Gram-negative bacteria present some of the most significant challenges in terms of antibiotic resistance. However, they are also able to be eliminated by the component of the innate immune system known as the complement system. In response, Gram-negative bacteria have evolved a variety of mechanisms by which they are able to evade complement and cause infection. Complement resistance mechanisms present some of the best novel therapeutic targets for defending against highly antibiotic-resistant pathogenic bacterial infections.https://www.mdpi.com/2076-0817/11/8/931complement systembacteriainnate immunitygram-negative bacteriacomplement resistance |
| spellingShingle | Marta K. Ruest Jonathan J. Dennis The Exploration of Complement-Resistance Mechanisms of Pathogenic Gram-Negative Bacteria to Support the Development of Novel Therapeutics Pathogens complement system bacteria innate immunity gram-negative bacteria complement resistance |
| title | The Exploration of Complement-Resistance Mechanisms of Pathogenic Gram-Negative Bacteria to Support the Development of Novel Therapeutics |
| title_full | The Exploration of Complement-Resistance Mechanisms of Pathogenic Gram-Negative Bacteria to Support the Development of Novel Therapeutics |
| title_fullStr | The Exploration of Complement-Resistance Mechanisms of Pathogenic Gram-Negative Bacteria to Support the Development of Novel Therapeutics |
| title_full_unstemmed | The Exploration of Complement-Resistance Mechanisms of Pathogenic Gram-Negative Bacteria to Support the Development of Novel Therapeutics |
| title_short | The Exploration of Complement-Resistance Mechanisms of Pathogenic Gram-Negative Bacteria to Support the Development of Novel Therapeutics |
| title_sort | exploration of complement resistance mechanisms of pathogenic gram negative bacteria to support the development of novel therapeutics |
| topic | complement system bacteria innate immunity gram-negative bacteria complement resistance |
| url | https://www.mdpi.com/2076-0817/11/8/931 |
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