A Link between Replicative Stress, Lamin Proteins, and Inflammation
Double-stranded breaks (DSB), the most toxic DNA lesions, are either a consequence of cellular metabolism, programmed as in during V(D)J recombination, or induced by anti-tumoral therapies or accidental genotoxic exposure. One origin of DSB sources is replicative stress, a major source of genome ins...
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MDPI AG
2021-04-01
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Online Access: | https://www.mdpi.com/2073-4425/12/4/552 |
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author | Simon Willaume Emilie Rass Paula Fontanilla-Ramirez Angela Moussa Paul Wanschoor Pascale Bertrand |
author_facet | Simon Willaume Emilie Rass Paula Fontanilla-Ramirez Angela Moussa Paul Wanschoor Pascale Bertrand |
author_sort | Simon Willaume |
collection | DOAJ |
description | Double-stranded breaks (DSB), the most toxic DNA lesions, are either a consequence of cellular metabolism, programmed as in during V(D)J recombination, or induced by anti-tumoral therapies or accidental genotoxic exposure. One origin of DSB sources is replicative stress, a major source of genome instability, especially when the integrity of the replication forks is not properly guaranteed. To complete stalled replication, restarting the fork requires complex molecular mechanisms, such as protection, remodeling, and processing. Recently, a link has been made between DNA damage accumulation and inflammation. Indeed, defects in DNA repair or in replication can lead to the release of DNA fragments in the cytosol. The recognition of this self-DNA by DNA sensors leads to the production of inflammatory factors. This beneficial response activating an innate immune response and destruction of cells bearing DNA damage may be considered as a novel part of DNA damage response. However, upon accumulation of DNA damage, a chronic inflammatory cellular microenvironment may lead to inflammatory pathologies, aging, and progression of tumor cells. Progress in understanding the molecular mechanisms of DNA damage repair, replication stress, and cytosolic DNA production would allow to propose new therapeutical strategies against cancer or inflammatory diseases associated with aging. In this review, we describe the mechanisms involved in DSB repair, the replicative stress management, and its consequences. We also focus on new emerging links between key components of the nuclear envelope, the lamins, and DNA repair, management of replicative stress, and inflammation. |
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issn | 2073-4425 |
language | English |
last_indexed | 2024-03-10T12:28:28Z |
publishDate | 2021-04-01 |
publisher | MDPI AG |
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series | Genes |
spelling | doaj.art-e3c3e478b15549b08b5b505b6d6cfb8a2023-11-21T14:54:32ZengMDPI AGGenes2073-44252021-04-0112455210.3390/genes12040552A Link between Replicative Stress, Lamin Proteins, and InflammationSimon Willaume0Emilie Rass1Paula Fontanilla-Ramirez2Angela Moussa3Paul Wanschoor4Pascale Bertrand5Université de Paris and Université Paris-Saclay, INSERM, iRCM/IBFJ, CEA, UMR Stabilité, Génétique Cellules Souches et Radiations, F-92265 Fontenay-aux-Roses, FranceUniversité de Paris and Université Paris-Saclay, INSERM, iRCM/IBFJ, CEA, UMR Stabilité, Génétique Cellules Souches et Radiations, F-92265 Fontenay-aux-Roses, FranceUniversité de Paris and Université Paris-Saclay, INSERM, iRCM/IBFJ, CEA, UMR Stabilité, Génétique Cellules Souches et Radiations, F-92265 Fontenay-aux-Roses, FranceUniversité de Paris and Université Paris-Saclay, INSERM, iRCM/IBFJ, CEA, UMR Stabilité, Génétique Cellules Souches et Radiations, F-92265 Fontenay-aux-Roses, FranceUniversité de Paris and Université Paris-Saclay, INSERM, iRCM/IBFJ, CEA, UMR Stabilité, Génétique Cellules Souches et Radiations, F-92265 Fontenay-aux-Roses, FranceUniversité de Paris and Université Paris-Saclay, INSERM, iRCM/IBFJ, CEA, UMR Stabilité, Génétique Cellules Souches et Radiations, F-92265 Fontenay-aux-Roses, FranceDouble-stranded breaks (DSB), the most toxic DNA lesions, are either a consequence of cellular metabolism, programmed as in during V(D)J recombination, or induced by anti-tumoral therapies or accidental genotoxic exposure. One origin of DSB sources is replicative stress, a major source of genome instability, especially when the integrity of the replication forks is not properly guaranteed. To complete stalled replication, restarting the fork requires complex molecular mechanisms, such as protection, remodeling, and processing. Recently, a link has been made between DNA damage accumulation and inflammation. Indeed, defects in DNA repair or in replication can lead to the release of DNA fragments in the cytosol. The recognition of this self-DNA by DNA sensors leads to the production of inflammatory factors. This beneficial response activating an innate immune response and destruction of cells bearing DNA damage may be considered as a novel part of DNA damage response. However, upon accumulation of DNA damage, a chronic inflammatory cellular microenvironment may lead to inflammatory pathologies, aging, and progression of tumor cells. Progress in understanding the molecular mechanisms of DNA damage repair, replication stress, and cytosolic DNA production would allow to propose new therapeutical strategies against cancer or inflammatory diseases associated with aging. In this review, we describe the mechanisms involved in DSB repair, the replicative stress management, and its consequences. We also focus on new emerging links between key components of the nuclear envelope, the lamins, and DNA repair, management of replicative stress, and inflammation.https://www.mdpi.com/2073-4425/12/4/552DNA replication stresslaminsHutchinson-Gilford progeria syndromeinflammationsenescenceaging |
spellingShingle | Simon Willaume Emilie Rass Paula Fontanilla-Ramirez Angela Moussa Paul Wanschoor Pascale Bertrand A Link between Replicative Stress, Lamin Proteins, and Inflammation Genes DNA replication stress lamins Hutchinson-Gilford progeria syndrome inflammation senescence aging |
title | A Link between Replicative Stress, Lamin Proteins, and Inflammation |
title_full | A Link between Replicative Stress, Lamin Proteins, and Inflammation |
title_fullStr | A Link between Replicative Stress, Lamin Proteins, and Inflammation |
title_full_unstemmed | A Link between Replicative Stress, Lamin Proteins, and Inflammation |
title_short | A Link between Replicative Stress, Lamin Proteins, and Inflammation |
title_sort | link between replicative stress lamin proteins and inflammation |
topic | DNA replication stress lamins Hutchinson-Gilford progeria syndrome inflammation senescence aging |
url | https://www.mdpi.com/2073-4425/12/4/552 |
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