New Insights into the Roles of lncRNAs as Modulators of Cytoskeleton Architecture and Their Implications in Cellular Homeostasis and in Tumorigenesis
The importance of the cytoskeleton not only in cell architecture but also as a pivotal element in the transduction of signals that mediate multiple biological processes has recently been highlighted. Broadly, the cytoskeleton consists of three types of structural proteins: (1) actin filaments, invol...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | Non-Coding RNA |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2311-553X/8/2/28 |
| _version_ | 1797409845119287296 |
|---|---|
| author | Carlos García-Padilla María del Mar Muñoz-Gallardo Estefanía Lozano-Velasco Juan Manuel Castillo-Casas Sheila Caño-Carrillo Virginio García-López Amelia Aránega Diego Franco Virginio García-Martínez Carmen López-Sánchez |
| author_facet | Carlos García-Padilla María del Mar Muñoz-Gallardo Estefanía Lozano-Velasco Juan Manuel Castillo-Casas Sheila Caño-Carrillo Virginio García-López Amelia Aránega Diego Franco Virginio García-Martínez Carmen López-Sánchez |
| author_sort | Carlos García-Padilla |
| collection | DOAJ |
| description | The importance of the cytoskeleton not only in cell architecture but also as a pivotal element in the transduction of signals that mediate multiple biological processes has recently been highlighted. Broadly, the cytoskeleton consists of three types of structural proteins: (1) actin filaments, involved in establishing and maintaining cell shape and movement; (2) microtubules, necessary to support the different organelles and distribution of chromosomes during cell cycle; and (3) intermediate filaments, which have a mainly structural function showing specificity for the cell type where they are expressed. Interaction between these protein structures is essential for the cytoskeletal mesh to be functional. Furthermore, the cytoskeleton is subject to intense spatio-temporal regulation mediated by the assembly and disassembly of its components. Loss of cytoskeleton homeostasis and integrity of cell focal adhesion are hallmarks of several cancer types. Recently, many reports have pointed out that lncRNAs could be critical mediators in cellular homeostasis controlling dynamic structure and stability of the network formed by cytoskeletal structures, specifically in different types of carcinomas. In this review, we summarize current information available about the roles of lncRNAs as modulators of actin dependent cytoskeleton and their impact on cancer pathogenesis. Finally, we explore other examples of cytoskeletal lncRNAs currently unrelated to tumorigenesis, to illustrate knowledge about them. |
| first_indexed | 2024-03-09T04:21:25Z |
| format | Article |
| id | doaj.art-e3c443562ad745f8822bf5a74bbfbb08 |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-03-09T04:21:25Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-e3c443562ad745f8822bf5a74bbfbb082023-12-03T13:47:51ZengMDPI AGNon-Coding RNA2311-553X2022-04-01822810.3390/ncrna8020028New Insights into the Roles of lncRNAs as Modulators of Cytoskeleton Architecture and Their Implications in Cellular Homeostasis and in TumorigenesisCarlos García-Padilla0María del Mar Muñoz-Gallardo1Estefanía Lozano-Velasco2Juan Manuel Castillo-Casas3Sheila Caño-Carrillo4Virginio García-López5Amelia Aránega6Diego Franco7Virginio García-Martínez8Carmen López-Sánchez9Department of Human Anatomy and Embryology, Faculty of Medicine, Institute of Molecular Pathology Biomarkers, University of Extremadura, 06006 Badajoz, SpainDepartment of Experimental Biology, University of Jaen, 23071 Jaen, SpainDepartment of Human Anatomy and Embryology, Faculty of Medicine, Institute of Molecular Pathology Biomarkers, University of Extremadura, 06006 Badajoz, SpainDepartment of Experimental Biology, University of Jaen, 23071 Jaen, SpainDepartment of Experimental Biology, University of Jaen, 23071 Jaen, SpainDepartment of Human Anatomy and Embryology, Faculty of Medicine, Institute of Molecular Pathology Biomarkers, University of Extremadura, 06006 Badajoz, SpainDepartment of Experimental Biology, University of Jaen, 23071 Jaen, SpainDepartment of Experimental Biology, University of Jaen, 23071 Jaen, SpainDepartment of Human Anatomy and Embryology, Faculty of Medicine, Institute of Molecular Pathology Biomarkers, University of Extremadura, 06006 Badajoz, SpainDepartment of Human Anatomy and Embryology, Faculty of Medicine, Institute of Molecular Pathology Biomarkers, University of Extremadura, 06006 Badajoz, SpainThe importance of the cytoskeleton not only in cell architecture but also as a pivotal element in the transduction of signals that mediate multiple biological processes has recently been highlighted. Broadly, the cytoskeleton consists of three types of structural proteins: (1) actin filaments, involved in establishing and maintaining cell shape and movement; (2) microtubules, necessary to support the different organelles and distribution of chromosomes during cell cycle; and (3) intermediate filaments, which have a mainly structural function showing specificity for the cell type where they are expressed. Interaction between these protein structures is essential for the cytoskeletal mesh to be functional. Furthermore, the cytoskeleton is subject to intense spatio-temporal regulation mediated by the assembly and disassembly of its components. Loss of cytoskeleton homeostasis and integrity of cell focal adhesion are hallmarks of several cancer types. Recently, many reports have pointed out that lncRNAs could be critical mediators in cellular homeostasis controlling dynamic structure and stability of the network formed by cytoskeletal structures, specifically in different types of carcinomas. In this review, we summarize current information available about the roles of lncRNAs as modulators of actin dependent cytoskeleton and their impact on cancer pathogenesis. Finally, we explore other examples of cytoskeletal lncRNAs currently unrelated to tumorigenesis, to illustrate knowledge about them.https://www.mdpi.com/2311-553X/8/2/28lncRNAsactin filamentscytoskeleton architecturecancertumorigenesis |
| spellingShingle | Carlos García-Padilla María del Mar Muñoz-Gallardo Estefanía Lozano-Velasco Juan Manuel Castillo-Casas Sheila Caño-Carrillo Virginio García-López Amelia Aránega Diego Franco Virginio García-Martínez Carmen López-Sánchez New Insights into the Roles of lncRNAs as Modulators of Cytoskeleton Architecture and Their Implications in Cellular Homeostasis and in Tumorigenesis Non-Coding RNA lncRNAs actin filaments cytoskeleton architecture cancer tumorigenesis |
| title | New Insights into the Roles of lncRNAs as Modulators of Cytoskeleton Architecture and Their Implications in Cellular Homeostasis and in Tumorigenesis |
| title_full | New Insights into the Roles of lncRNAs as Modulators of Cytoskeleton Architecture and Their Implications in Cellular Homeostasis and in Tumorigenesis |
| title_fullStr | New Insights into the Roles of lncRNAs as Modulators of Cytoskeleton Architecture and Their Implications in Cellular Homeostasis and in Tumorigenesis |
| title_full_unstemmed | New Insights into the Roles of lncRNAs as Modulators of Cytoskeleton Architecture and Their Implications in Cellular Homeostasis and in Tumorigenesis |
| title_short | New Insights into the Roles of lncRNAs as Modulators of Cytoskeleton Architecture and Their Implications in Cellular Homeostasis and in Tumorigenesis |
| title_sort | new insights into the roles of lncrnas as modulators of cytoskeleton architecture and their implications in cellular homeostasis and in tumorigenesis |
| topic | lncRNAs actin filaments cytoskeleton architecture cancer tumorigenesis |
| url | https://www.mdpi.com/2311-553X/8/2/28 |
| work_keys_str_mv | AT carlosgarciapadilla newinsightsintotherolesoflncrnasasmodulatorsofcytoskeletonarchitectureandtheirimplicationsincellularhomeostasisandintumorigenesis AT mariadelmarmunozgallardo newinsightsintotherolesoflncrnasasmodulatorsofcytoskeletonarchitectureandtheirimplicationsincellularhomeostasisandintumorigenesis AT estefanialozanovelasco newinsightsintotherolesoflncrnasasmodulatorsofcytoskeletonarchitectureandtheirimplicationsincellularhomeostasisandintumorigenesis AT juanmanuelcastillocasas newinsightsintotherolesoflncrnasasmodulatorsofcytoskeletonarchitectureandtheirimplicationsincellularhomeostasisandintumorigenesis AT sheilacanocarrillo newinsightsintotherolesoflncrnasasmodulatorsofcytoskeletonarchitectureandtheirimplicationsincellularhomeostasisandintumorigenesis AT virginiogarcialopez newinsightsintotherolesoflncrnasasmodulatorsofcytoskeletonarchitectureandtheirimplicationsincellularhomeostasisandintumorigenesis AT ameliaaranega newinsightsintotherolesoflncrnasasmodulatorsofcytoskeletonarchitectureandtheirimplicationsincellularhomeostasisandintumorigenesis AT diegofranco newinsightsintotherolesoflncrnasasmodulatorsofcytoskeletonarchitectureandtheirimplicationsincellularhomeostasisandintumorigenesis AT virginiogarciamartinez newinsightsintotherolesoflncrnasasmodulatorsofcytoskeletonarchitectureandtheirimplicationsincellularhomeostasisandintumorigenesis AT carmenlopezsanchez newinsightsintotherolesoflncrnasasmodulatorsofcytoskeletonarchitectureandtheirimplicationsincellularhomeostasisandintumorigenesis |