Protein-Targeted Degradation Agents Based on Natural Products
Natural products are an important source of drug lead compounds, and natural products with significant biological activity are constantly being discovered and used in clinical practice. At present, natural products play an important role in the targeted therapy of cancer, cardiovascular and cerebrov...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/16/1/46 |
| _version_ | 1797437950176264192 |
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| author | Yan Li Yi Jia Xiaolin Wang Hai Shang Yu Tian |
| author_facet | Yan Li Yi Jia Xiaolin Wang Hai Shang Yu Tian |
| author_sort | Yan Li |
| collection | DOAJ |
| description | Natural products are an important source of drug lead compounds, and natural products with significant biological activity are constantly being discovered and used in clinical practice. At present, natural products play an important role in the targeted therapy of cancer, cardiovascular and cerebrovascular diseases, nervous system diseases, and autoimmune diseases. Meanwhile, in recent years, the rise of protein-targeted degradation technologies, such as proteolysis-targeting chimeras (PROTACs) and molecular glues, has provided a new solution for drug resistance caused by clinical molecular-targeting drugs. It is noteworthy that natural products and their derivatives, as important components of PROTACs and molecular glues, play an important role in the development of protein-targeting drugs. Hence, this review summarized the protein-targeted degradation agents based on natural products, such as PROTACs and molecular glues. More natural products with the potential to be used in the development of PROTACs and molecular glues as targeted protein degradation agents are still being investigated. |
| first_indexed | 2024-03-09T11:29:57Z |
| format | Article |
| id | doaj.art-e3c46adf2d6143d484267bf59e65a595 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T11:29:57Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-e3c46adf2d6143d484267bf59e65a5952023-11-30T23:55:01ZengMDPI AGPharmaceuticals1424-82472022-12-011614610.3390/ph16010046Protein-Targeted Degradation Agents Based on Natural ProductsYan Li0Yi Jia1Xiaolin Wang2Hai Shang3Yu Tian4Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaNatural products are an important source of drug lead compounds, and natural products with significant biological activity are constantly being discovered and used in clinical practice. At present, natural products play an important role in the targeted therapy of cancer, cardiovascular and cerebrovascular diseases, nervous system diseases, and autoimmune diseases. Meanwhile, in recent years, the rise of protein-targeted degradation technologies, such as proteolysis-targeting chimeras (PROTACs) and molecular glues, has provided a new solution for drug resistance caused by clinical molecular-targeting drugs. It is noteworthy that natural products and their derivatives, as important components of PROTACs and molecular glues, play an important role in the development of protein-targeting drugs. Hence, this review summarized the protein-targeted degradation agents based on natural products, such as PROTACs and molecular glues. More natural products with the potential to be used in the development of PROTACs and molecular glues as targeted protein degradation agents are still being investigated.https://www.mdpi.com/1424-8247/16/1/46natural productsmolecular-targeted drugstargeted protein degradation agentsPROTACmolecular glue |
| spellingShingle | Yan Li Yi Jia Xiaolin Wang Hai Shang Yu Tian Protein-Targeted Degradation Agents Based on Natural Products Pharmaceuticals natural products molecular-targeted drugs targeted protein degradation agents PROTAC molecular glue |
| title | Protein-Targeted Degradation Agents Based on Natural Products |
| title_full | Protein-Targeted Degradation Agents Based on Natural Products |
| title_fullStr | Protein-Targeted Degradation Agents Based on Natural Products |
| title_full_unstemmed | Protein-Targeted Degradation Agents Based on Natural Products |
| title_short | Protein-Targeted Degradation Agents Based on Natural Products |
| title_sort | protein targeted degradation agents based on natural products |
| topic | natural products molecular-targeted drugs targeted protein degradation agents PROTAC molecular glue |
| url | https://www.mdpi.com/1424-8247/16/1/46 |
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