Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients.
SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-2), cause of COVID-19 (Coronavirus Disease of 2019), represents a significant risk to people living with pre-existing conditions associated with exacerbated inflammatory responses and consequent dysfunctional immunity. In this paper, we have...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0245424 |
| _version_ | 1826554392720965632 |
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| author | Daniela Frasca Lisa Reidy Carolyn Cray Alain Diaz Maria Romero Kristin Kahl Bonnie B Blomberg |
| author_facet | Daniela Frasca Lisa Reidy Carolyn Cray Alain Diaz Maria Romero Kristin Kahl Bonnie B Blomberg |
| author_sort | Daniela Frasca |
| collection | DOAJ |
| description | SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-2), cause of COVID-19 (Coronavirus Disease of 2019), represents a significant risk to people living with pre-existing conditions associated with exacerbated inflammatory responses and consequent dysfunctional immunity. In this paper, we have evaluated the influence of obesity, a condition associated with chronic systemic inflammation, on the secretion of SARS-CoV-2-specific IgG antibodies in the blood of COVID-19 patients. Our hypothesis is that obesity is associated with reduced amounts of specific IgG antibodies. Results have confirmed our hypothesis and have shown that SARS-CoV-2 IgG antibodies are negatively associated with Body Mass Index (BMI) in COVID-19 obese patients, as expected based on the known influence of obesity on humoral immunity. Antibodies in COVID-19 obese patients are also negatively associated with serum levels of pro-inflammatory and metabolic markers of inflammaging and pulmonary inflammation, such as SAA (serum amyloid A protein), CRP (C-reactive protein), and ferritin, but positively associated with NEFA (nonesterified fatty acids). These results altogether could help to identify an inflammatory signature with strong predictive value for immune dysfunction. Inflammatory markers identified may subsequently be targeted to improve humoral immunity in individuals with obesity and in individuals with other chronic inflammatory conditions. |
| first_indexed | 2024-12-13T21:23:16Z |
| format | Article |
| id | doaj.art-e3c56a4c19304b4dbb4bd70abc5470d1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2025-03-14T07:40:11Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e3c56a4c19304b4dbb4bd70abc5470d12025-03-03T05:36:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01163e024542410.1371/journal.pone.0245424Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients.Daniela FrascaLisa ReidyCarolyn CrayAlain DiazMaria RomeroKristin KahlBonnie B BlombergSARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-2), cause of COVID-19 (Coronavirus Disease of 2019), represents a significant risk to people living with pre-existing conditions associated with exacerbated inflammatory responses and consequent dysfunctional immunity. In this paper, we have evaluated the influence of obesity, a condition associated with chronic systemic inflammation, on the secretion of SARS-CoV-2-specific IgG antibodies in the blood of COVID-19 patients. Our hypothesis is that obesity is associated with reduced amounts of specific IgG antibodies. Results have confirmed our hypothesis and have shown that SARS-CoV-2 IgG antibodies are negatively associated with Body Mass Index (BMI) in COVID-19 obese patients, as expected based on the known influence of obesity on humoral immunity. Antibodies in COVID-19 obese patients are also negatively associated with serum levels of pro-inflammatory and metabolic markers of inflammaging and pulmonary inflammation, such as SAA (serum amyloid A protein), CRP (C-reactive protein), and ferritin, but positively associated with NEFA (nonesterified fatty acids). These results altogether could help to identify an inflammatory signature with strong predictive value for immune dysfunction. Inflammatory markers identified may subsequently be targeted to improve humoral immunity in individuals with obesity and in individuals with other chronic inflammatory conditions.https://doi.org/10.1371/journal.pone.0245424 |
| spellingShingle | Daniela Frasca Lisa Reidy Carolyn Cray Alain Diaz Maria Romero Kristin Kahl Bonnie B Blomberg Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients. PLoS ONE |
| title | Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients. |
| title_full | Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients. |
| title_fullStr | Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients. |
| title_full_unstemmed | Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients. |
| title_short | Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients. |
| title_sort | influence of obesity on serum levels of sars cov 2 specific antibodies in covid 19 patients |
| url | https://doi.org/10.1371/journal.pone.0245424 |
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