Deleted in Liver Cancer 2 (DLC2) protein expression in hepatocellular carcinoma
Deleted in Liver Cancer (DLC) proteins belong to the family of RhoGAPs and are believed to operate as negative regulators of the Rho family of small GTPases. So far, the role of the first identified member from the DLC family, DLC1, was established as a tumor suppressor in hepatocellular carcinoma....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2019-02-01
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| Series: | European Journal of Histochemistry |
| Subjects: | |
| Online Access: | https://ejh.it/index.php/ejh/article/view/2981 |
| _version_ | 1818568423780646912 |
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| author | Dominika Wolosz Agnieszka Walczak Grzegorz Szparecki Michal Dwojak Magdalena Winiarska Ewa Wolinska Barbara Gornicka |
| author_facet | Dominika Wolosz Agnieszka Walczak Grzegorz Szparecki Michal Dwojak Magdalena Winiarska Ewa Wolinska Barbara Gornicka |
| author_sort | Dominika Wolosz |
| collection | DOAJ |
| description | Deleted in Liver Cancer (DLC) proteins belong to the family of RhoGAPs and are believed to operate as negative regulators of the Rho family of small GTPases. So far, the role of the first identified member from the DLC family, DLC1, was established as a tumor suppressor in hepatocellular carcinoma. The function of its close family relative, DLC2 is unequivocal. In the present study we attempted to determine whether the loss of DLC2 is a common feature of hepatocellular carcinoma tissue. We examined two types of hepatocellular carcinoma- typical and fibrolamellar one. Our analysis revealed that DLC2 protein is not diminished in cancer tissue when compared to non-cancerous liver specimens. What is more, we observed DLC2 to be more abundantly expressed in cancer tissue, particularly in tumors with the inflammation background. In addition, we found that DLC2 gene status was diploid in virtually all tumor samples examined. Our results indicate that DLC2 is not diminished in hepatocellular carcinoma cells. It appears that members of the DLC family, although structurally highly related, may function differently in cancer cells. |
| first_indexed | 2024-12-14T06:35:19Z |
| format | Article |
| id | doaj.art-e3c686369b4847e5a2afd848dcd5fa4b |
| institution | Directory Open Access Journal |
| issn | 1121-760X 2038-8306 |
| language | English |
| last_indexed | 2024-12-14T06:35:19Z |
| publishDate | 2019-02-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj.art-e3c686369b4847e5a2afd848dcd5fa4b2022-12-21T23:13:24ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062019-02-0163110.4081/ejh.2019.2981Deleted in Liver Cancer 2 (DLC2) protein expression in hepatocellular carcinomaDominika Wolosz0Agnieszka Walczak1Grzegorz Szparecki2Michal Dwojak3Magdalena Winiarska4Ewa Wolinska5Barbara Gornicka6Medical University of Warsaw, Department of PathologyPolish Academy of Sciences, Nencki Institute of Experimental Biology - Adam Mickiewicz University, Department of Gene ExpressionMedical University of Warsaw, Department of PathologyMedical University of Warsaw, Center for Biostructure ResearchMedical University of Warsaw, Center for Biostructure ResearchMedical University of Warsaw, Department of PathologyMedical University of Warsaw, Department of PathologyDeleted in Liver Cancer (DLC) proteins belong to the family of RhoGAPs and are believed to operate as negative regulators of the Rho family of small GTPases. So far, the role of the first identified member from the DLC family, DLC1, was established as a tumor suppressor in hepatocellular carcinoma. The function of its close family relative, DLC2 is unequivocal. In the present study we attempted to determine whether the loss of DLC2 is a common feature of hepatocellular carcinoma tissue. We examined two types of hepatocellular carcinoma- typical and fibrolamellar one. Our analysis revealed that DLC2 protein is not diminished in cancer tissue when compared to non-cancerous liver specimens. What is more, we observed DLC2 to be more abundantly expressed in cancer tissue, particularly in tumors with the inflammation background. In addition, we found that DLC2 gene status was diploid in virtually all tumor samples examined. Our results indicate that DLC2 is not diminished in hepatocellular carcinoma cells. It appears that members of the DLC family, although structurally highly related, may function differently in cancer cells.https://ejh.it/index.php/ejh/article/view/2981DLC2hepatocellular carcinomafibrolamellar hepatocellular carcinoma |
| spellingShingle | Dominika Wolosz Agnieszka Walczak Grzegorz Szparecki Michal Dwojak Magdalena Winiarska Ewa Wolinska Barbara Gornicka Deleted in Liver Cancer 2 (DLC2) protein expression in hepatocellular carcinoma European Journal of Histochemistry DLC2 hepatocellular carcinoma fibrolamellar hepatocellular carcinoma |
| title | Deleted in Liver Cancer 2 (DLC2) protein expression in hepatocellular carcinoma |
| title_full | Deleted in Liver Cancer 2 (DLC2) protein expression in hepatocellular carcinoma |
| title_fullStr | Deleted in Liver Cancer 2 (DLC2) protein expression in hepatocellular carcinoma |
| title_full_unstemmed | Deleted in Liver Cancer 2 (DLC2) protein expression in hepatocellular carcinoma |
| title_short | Deleted in Liver Cancer 2 (DLC2) protein expression in hepatocellular carcinoma |
| title_sort | deleted in liver cancer 2 dlc2 protein expression in hepatocellular carcinoma |
| topic | DLC2 hepatocellular carcinoma fibrolamellar hepatocellular carcinoma |
| url | https://ejh.it/index.php/ejh/article/view/2981 |
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