Long-Term Feasibility of 13.56 MHz Modulated Electro-Hyperthermia-Based Preoperative Thermoradiochemotherapy in Locally Advanced Rectal Cancer
We evaluated the effect of 13.56 MHz modulated electro-hyperthermia (mEHT) boost in neoadjuvant treatment for cT3-4- or cN-positive rectal cancer. Sixty patients who completed the mEHT feasibility trial (ClinicalTrials.gov Identifier: NCT02546596) were analyzed. Whole pelvis radiotherapy of 40 Gy, m...
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MDPI AG
2022-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/5/1271 |
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| author | Yohan Lee Sunghyun Kim Hyejung Cha Jae Hun Han Hyun Joon Choi Eun Go Sei Hwan You |
| author_facet | Yohan Lee Sunghyun Kim Hyejung Cha Jae Hun Han Hyun Joon Choi Eun Go Sei Hwan You |
| author_sort | Yohan Lee |
| collection | DOAJ |
| description | We evaluated the effect of 13.56 MHz modulated electro-hyperthermia (mEHT) boost in neoadjuvant treatment for cT3-4- or cN-positive rectal cancer. Sixty patients who completed the mEHT feasibility trial (ClinicalTrials.gov Identifier: NCT02546596) were analyzed. Whole pelvis radiotherapy of 40 Gy, mEHT boost twice a week during radiotherapy, and surgical resection 6–8 weeks following radiotherapy were performed. The median age was 59. The median follow-up period was 58 (6–85) months. Total/near total tumor regression was observed in 20 patients (33.3%), including nine cases of complete response. T- and N-downstaging was identified in 40 (66.6%) and 53 (88.3%) patients, respectively. The 5-year overall and disease-free survival were 94.0% and 77.1%, respectively. mEHT energy of ≥3800 kJ potentially increased the overall survival (<i>p</i> = 0.039). The ypN-stage and perineural invasion were possible significant factors in disease-free (<i>p</i> = 0.003 and <i>p</i> = 0.005, respectively) and distant metastasis-free (<i>p</i> = 0.011 and <i>p</i> = 0.034, respectively) survival. Tumor regression, resection margin status, and other molecular genetic factors showed no correlation with survival. Although a limited analysis of a small number of patients, mEHT was feasible considering long-term survival. A relatively low dose irradiation (40 Gy) plus mEHT setting could ensure comparable clinical outcomes with possible mEHT-related prognostic features. |
| first_indexed | 2024-03-09T20:45:11Z |
| format | Article |
| id | doaj.art-e3c6ac18e4a34558b7e36db75505e5dc |
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| language | English |
| last_indexed | 2024-03-09T20:45:11Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
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| series | Cancers |
| spelling | doaj.art-e3c6ac18e4a34558b7e36db75505e5dc2023-11-23T22:48:28ZengMDPI AGCancers2072-66942022-03-01145127110.3390/cancers14051271Long-Term Feasibility of 13.56 MHz Modulated Electro-Hyperthermia-Based Preoperative Thermoradiochemotherapy in Locally Advanced Rectal CancerYohan Lee0Sunghyun Kim1Hyejung Cha2Jae Hun Han3Hyun Joon Choi4Eun Go5Sei Hwan You6Department of Radiation Oncology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju 26426, KoreaDepartment of Radiation Oncology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju 26426, KoreaDepartment of Radiation Oncology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju 26426, KoreaDepartment of Biostatistics, Yonsei University Wonju College of Medicine, Wonju 26426, KoreaDepartment of Radiation Oncology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju 26426, KoreaDepartment of Software, College of Software and Digital Healthcare Convergence, Yonsei University, Wonju 26493, KoreaDepartment of Radiation Oncology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju 26426, KoreaWe evaluated the effect of 13.56 MHz modulated electro-hyperthermia (mEHT) boost in neoadjuvant treatment for cT3-4- or cN-positive rectal cancer. Sixty patients who completed the mEHT feasibility trial (ClinicalTrials.gov Identifier: NCT02546596) were analyzed. Whole pelvis radiotherapy of 40 Gy, mEHT boost twice a week during radiotherapy, and surgical resection 6–8 weeks following radiotherapy were performed. The median age was 59. The median follow-up period was 58 (6–85) months. Total/near total tumor regression was observed in 20 patients (33.3%), including nine cases of complete response. T- and N-downstaging was identified in 40 (66.6%) and 53 (88.3%) patients, respectively. The 5-year overall and disease-free survival were 94.0% and 77.1%, respectively. mEHT energy of ≥3800 kJ potentially increased the overall survival (<i>p</i> = 0.039). The ypN-stage and perineural invasion were possible significant factors in disease-free (<i>p</i> = 0.003 and <i>p</i> = 0.005, respectively) and distant metastasis-free (<i>p</i> = 0.011 and <i>p</i> = 0.034, respectively) survival. Tumor regression, resection margin status, and other molecular genetic factors showed no correlation with survival. Although a limited analysis of a small number of patients, mEHT was feasible considering long-term survival. A relatively low dose irradiation (40 Gy) plus mEHT setting could ensure comparable clinical outcomes with possible mEHT-related prognostic features.https://www.mdpi.com/2072-6694/14/5/1271regional hyperthermiarectal cancerneoadjuvant chemoradiationsurvival |
| spellingShingle | Yohan Lee Sunghyun Kim Hyejung Cha Jae Hun Han Hyun Joon Choi Eun Go Sei Hwan You Long-Term Feasibility of 13.56 MHz Modulated Electro-Hyperthermia-Based Preoperative Thermoradiochemotherapy in Locally Advanced Rectal Cancer Cancers regional hyperthermia rectal cancer neoadjuvant chemoradiation survival |
| title | Long-Term Feasibility of 13.56 MHz Modulated Electro-Hyperthermia-Based Preoperative Thermoradiochemotherapy in Locally Advanced Rectal Cancer |
| title_full | Long-Term Feasibility of 13.56 MHz Modulated Electro-Hyperthermia-Based Preoperative Thermoradiochemotherapy in Locally Advanced Rectal Cancer |
| title_fullStr | Long-Term Feasibility of 13.56 MHz Modulated Electro-Hyperthermia-Based Preoperative Thermoradiochemotherapy in Locally Advanced Rectal Cancer |
| title_full_unstemmed | Long-Term Feasibility of 13.56 MHz Modulated Electro-Hyperthermia-Based Preoperative Thermoradiochemotherapy in Locally Advanced Rectal Cancer |
| title_short | Long-Term Feasibility of 13.56 MHz Modulated Electro-Hyperthermia-Based Preoperative Thermoradiochemotherapy in Locally Advanced Rectal Cancer |
| title_sort | long term feasibility of 13 56 mhz modulated electro hyperthermia based preoperative thermoradiochemotherapy in locally advanced rectal cancer |
| topic | regional hyperthermia rectal cancer neoadjuvant chemoradiation survival |
| url | https://www.mdpi.com/2072-6694/14/5/1271 |
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