Cytoreductive HIPEC-Combined Surgery in Treatment of Advanced Ovarian Cancer
Background. Ovarian cancer ranks 5th in the structure of female oncological mortality in the Russian Federation, with a first-year post-diagnosis rate of almost 35%. In 75% cases, ovarian cancer is diagnosed at stages III—IV. The disease usually represents as peritoneal carcinomatosis regarded as an...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bashkir State Medical University
2022-06-01
|
| Series: | Креативная хирургия и онкология |
| Subjects: | |
| Online Access: | https://www.surgonco.ru/jour/article/view/671 |
| _version_ | 1797872383077384192 |
|---|---|
| author | M. V. Zabelin A. S. Safonov N. V. Kuznetsov |
| author_facet | M. V. Zabelin A. S. Safonov N. V. Kuznetsov |
| author_sort | M. V. Zabelin |
| collection | DOAJ |
| description | Background. Ovarian cancer ranks 5th in the structure of female oncological mortality in the Russian Federation, with a first-year post-diagnosis rate of almost 35%. In 75% cases, ovarian cancer is diagnosed at stages III—IV. The disease usually represents as peritoneal carcinomatosis regarded as an advanced form that demands attention, which renders the issue highly relevant. We present a literature review and analysis of combined treatment outcomes in ovarian cancer patients hospitalised at the Kuvatov Republican Clinical Hospital within period 2020—2021.Materials and methods. The article reviews foreign and national scientific literature, as well as reports the case data on 18 patients diagnosed with ovarian cancer and treated at the Department of Oncology of the Kuvatov Republican Clinical Hospital within period 2020—2021.Results and discussion. A complete cytoreductive surgery was performed in 100% cases. In cohort I, mean operation time was 256 vs. 364 min, mean intraoperative blood loss — 1200 vs. 1050 mL, mean hospital stay — 14.6 vs. 18.7 bed-days. Postoperative complications were 16.7 vs. 50% in cohort I vs. II. A 30-day mortality rate was 0 vs. 16.6% in cohort I vs. II. The monitoring and enrolment of patients currently continues.Conclusion. A HIPEC procedure is not a radical measure and can only achieve a maximum efficacy if coupled with a complete cytoreduction. The treatment of stage III—IV ovarian cancer patients in a concurrent combined approach is promising and requires further in-depth research and a more robust statistics. |
| first_indexed | 2024-04-10T00:57:51Z |
| format | Article |
| id | doaj.art-e3c89c59be6e46e0ab5b828145ba5e1b |
| institution | Directory Open Access Journal |
| issn | 2307-0501 2076-3093 |
| language | English |
| last_indexed | 2024-04-10T00:57:51Z |
| publishDate | 2022-06-01 |
| publisher | Bashkir State Medical University |
| record_format | Article |
| series | Креативная хирургия и онкология |
| spelling | doaj.art-e3c89c59be6e46e0ab5b828145ba5e1b2023-03-13T10:01:10ZengBashkir State Medical UniversityКреативная хирургия и онкология2307-05012076-30932022-06-01121283410.24060/2076-3093-2022-12-1-28-34462Cytoreductive HIPEC-Combined Surgery in Treatment of Advanced Ovarian CancerM. V. Zabelin0A. S. Safonov1N. V. Kuznetsov2Государственный научный центр Российской Федерации — Федеральный медицинский биофизический центр им. А.И. Бурназяна ФМБАГосударственный научный центр Российской Федерации — Федеральный медицинский биофизический центр им. А.И. Бурназяна ФМБА; Республиканская клиническая больница им. Г.Г. КуватоваРеспубликанская клиническая больница им. Г.Г. КуватоваBackground. Ovarian cancer ranks 5th in the structure of female oncological mortality in the Russian Federation, with a first-year post-diagnosis rate of almost 35%. In 75% cases, ovarian cancer is diagnosed at stages III—IV. The disease usually represents as peritoneal carcinomatosis regarded as an advanced form that demands attention, which renders the issue highly relevant. We present a literature review and analysis of combined treatment outcomes in ovarian cancer patients hospitalised at the Kuvatov Republican Clinical Hospital within period 2020—2021.Materials and methods. The article reviews foreign and national scientific literature, as well as reports the case data on 18 patients diagnosed with ovarian cancer and treated at the Department of Oncology of the Kuvatov Republican Clinical Hospital within period 2020—2021.Results and discussion. A complete cytoreductive surgery was performed in 100% cases. In cohort I, mean operation time was 256 vs. 364 min, mean intraoperative blood loss — 1200 vs. 1050 mL, mean hospital stay — 14.6 vs. 18.7 bed-days. Postoperative complications were 16.7 vs. 50% in cohort I vs. II. A 30-day mortality rate was 0 vs. 16.6% in cohort I vs. II. The monitoring and enrolment of patients currently continues.Conclusion. A HIPEC procedure is not a radical measure and can only achieve a maximum efficacy if coupled with a complete cytoreduction. The treatment of stage III—IV ovarian cancer patients in a concurrent combined approach is promising and requires further in-depth research and a more robust statistics.https://www.surgonco.ru/jour/article/view/671рак яичниковhipecгипертермическая интраперитонеальная химиотерапияциторедуктивная хирургияперитонеальный канцероматозпослеоперационные осложнениярецидив |
| spellingShingle | M. V. Zabelin A. S. Safonov N. V. Kuznetsov Cytoreductive HIPEC-Combined Surgery in Treatment of Advanced Ovarian Cancer Креативная хирургия и онкология рак яичников hipec гипертермическая интраперитонеальная химиотерапия циторедуктивная хирургия перитонеальный канцероматоз послеоперационные осложнения рецидив |
| title | Cytoreductive HIPEC-Combined Surgery in Treatment of Advanced Ovarian Cancer |
| title_full | Cytoreductive HIPEC-Combined Surgery in Treatment of Advanced Ovarian Cancer |
| title_fullStr | Cytoreductive HIPEC-Combined Surgery in Treatment of Advanced Ovarian Cancer |
| title_full_unstemmed | Cytoreductive HIPEC-Combined Surgery in Treatment of Advanced Ovarian Cancer |
| title_short | Cytoreductive HIPEC-Combined Surgery in Treatment of Advanced Ovarian Cancer |
| title_sort | cytoreductive hipec combined surgery in treatment of advanced ovarian cancer |
| topic | рак яичников hipec гипертермическая интраперитонеальная химиотерапия циторедуктивная хирургия перитонеальный канцероматоз послеоперационные осложнения рецидив |
| url | https://www.surgonco.ru/jour/article/view/671 |
| work_keys_str_mv | AT mvzabelin cytoreductivehipeccombinedsurgeryintreatmentofadvancedovariancancer AT assafonov cytoreductivehipeccombinedsurgeryintreatmentofadvancedovariancancer AT nvkuznetsov cytoreductivehipeccombinedsurgeryintreatmentofadvancedovariancancer |