Minocycline Ameliorates Depressive-Like Behavior and Demyelination Induced by Transient Global Cerebral Ischemia by Inhibiting Microglial Activation

Minocycline Ameliorates Depressive-Like Behavior and Demyelination Induced by Transient Global Cerebral Ischemia by Inhibiting Microglial Activation

Global cerebral ischemia (GCI) commonly occurs in the elderly. Subcortical white matter lesions and oligodendrocyte (OLG) loss caused by cerebral ischemia have been implicated in the development of post-ischemic depression and cognitive impairment. OLGs are necessary for axonal myelination; the disr...

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Bibliographic Details
Main Authors: Bingying Du, Hailong Li, Huiwen Zheng, Cunxiu Fan, Meng Liang, Yongjie Lian, Zelan Wei, Yanbo Zhang, Xiaoying Bi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
cerebral ischemia
oligodendrocyte
myelin
microglia
minocycline
vascular depression
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01247/full

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