Relationships among egfr, vitamin d metabolites and pth 1-84 in ckd.
Vitamin D undergoes 25-hydroxylation in the liver (25D) and 1-alpha hydroxylation in the kidney (1,25D). Both [25D] and [1,25D] fell with GFR in surveys of patients with CKD. Because 1,25D suppresses transcription of the PTH gene, low [1,25D] is thought to be a cause of high [PTH] in CKD. To examine...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Korean Society of Nephrology
2012-06-01
|
| Series: | Kidney Research and Clinical Practice |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211913212005542 |
| _version_ | 1818446314269048832 |
|---|---|
| author | K. Phelps R. Mathew K. Stote L. Hewson D. Hallenbeck |
| author_facet | K. Phelps R. Mathew K. Stote L. Hewson D. Hallenbeck |
| author_sort | K. Phelps |
| collection | DOAJ |
| description | Vitamin D undergoes 25-hydroxylation in the liver (25D) and 1-alpha hydroxylation in the kidney (1,25D). Both [25D] and [1,25D] fell with GFR in surveys of patients with CKD. Because 1,25D suppresses transcription of the PTH gene, low [1,25D] is thought to be a cause of high [PTH] in CKD. To examine relationships among eGFR, [PTH] 1–84 (Scantibodies), [25D], and [1,25D], we studied 8 normal subjects with eGFR 73–103 and 29 patients with eGFR 14–49 ml/min/1.73 m2. Most patients had been taking supplemental vitamin D. Means (SEM) were compared by two-tailed t-test, and regressions were examined as indicated below. Results are summarized in the tables.
Variable
CKD (n=29)
Nl (n=8)
p
eGFR (ml/min/1.73 m2)
30.0 (1.7)
88.6 (4.0)
< 0.001
[PTH] pg/ml
80.6 (8.6)
30.1 (3.7)
0.005
[25D] ng/ml
35.2 (2.5)
39.7 (3.4)
0.4
[1,25D] pg/ml
42.5 (3.6)
55.1 (4.8)
0.1
CKD (n=29)
Nl (n=8)
Regression
R2
p
R2
p
[PTH] on eGFR
0.36
< 0.001
0.13
0.4
[25D] on eGFR
0.001
0.9
0.01
0.8
[1,25D] on eGFR
0.20
0.014
0.12
0.4
[1,25D] on [25D]
0.37
< 0.001
0.18
0.3
[PTH] on [25D]
0.02
0.5
0.03
0.7
[PTH] on [1,25D]
0.03
0.4
0.003
0.9In comparison to normal subjects, patients with CKD had lower eGFR, higher [PTH], and similar [25D] and [1,25D]. In the patients with CKD, [1,25D] varied directly and [PTH] inversely with eGFR. Unlike [1,25D], [25D] was not associated with eGFR, but [1,25D] nevertheless correlated strongly with [25D]. [PTH] was not related to [25D] or [1,25D]. In our patients with CKD, many of whom were vitamin D-replete, [25OHD] was the principal determinant of [1,25D]. Increased [PTH] could not be attributed to decreased [1,25D]. |
| first_indexed | 2024-12-14T19:45:45Z |
| format | Article |
| id | doaj.art-e3cb6a02781d45dfbb7113ce01a8414a |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-14T19:45:45Z |
| publishDate | 2012-06-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-e3cb6a02781d45dfbb7113ce01a8414a2022-12-21T22:49:35ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322012-06-01312A6610.1016/j.krcp.2012.04.521Relationships among egfr, vitamin d metabolites and pth 1-84 in ckd.K. PhelpsR. MathewK. StoteL. HewsonD. HallenbeckVitamin D undergoes 25-hydroxylation in the liver (25D) and 1-alpha hydroxylation in the kidney (1,25D). Both [25D] and [1,25D] fell with GFR in surveys of patients with CKD. Because 1,25D suppresses transcription of the PTH gene, low [1,25D] is thought to be a cause of high [PTH] in CKD. To examine relationships among eGFR, [PTH] 1–84 (Scantibodies), [25D], and [1,25D], we studied 8 normal subjects with eGFR 73–103 and 29 patients with eGFR 14–49 ml/min/1.73 m2. Most patients had been taking supplemental vitamin D. Means (SEM) were compared by two-tailed t-test, and regressions were examined as indicated below. Results are summarized in the tables. Variable CKD (n=29) Nl (n=8) p eGFR (ml/min/1.73 m2) 30.0 (1.7) 88.6 (4.0) < 0.001 [PTH] pg/ml 80.6 (8.6) 30.1 (3.7) 0.005 [25D] ng/ml 35.2 (2.5) 39.7 (3.4) 0.4 [1,25D] pg/ml 42.5 (3.6) 55.1 (4.8) 0.1 CKD (n=29) Nl (n=8) Regression R2 p R2 p [PTH] on eGFR 0.36 < 0.001 0.13 0.4 [25D] on eGFR 0.001 0.9 0.01 0.8 [1,25D] on eGFR 0.20 0.014 0.12 0.4 [1,25D] on [25D] 0.37 < 0.001 0.18 0.3 [PTH] on [25D] 0.02 0.5 0.03 0.7 [PTH] on [1,25D] 0.03 0.4 0.003 0.9In comparison to normal subjects, patients with CKD had lower eGFR, higher [PTH], and similar [25D] and [1,25D]. In the patients with CKD, [1,25D] varied directly and [PTH] inversely with eGFR. Unlike [1,25D], [25D] was not associated with eGFR, but [1,25D] nevertheless correlated strongly with [25D]. [PTH] was not related to [25D] or [1,25D]. In our patients with CKD, many of whom were vitamin D-replete, [25OHD] was the principal determinant of [1,25D]. Increased [PTH] could not be attributed to decreased [1,25D].http://www.sciencedirect.com/science/article/pii/S2211913212005542 |
| spellingShingle | K. Phelps R. Mathew K. Stote L. Hewson D. Hallenbeck Relationships among egfr, vitamin d metabolites and pth 1-84 in ckd. Kidney Research and Clinical Practice |
| title | Relationships among egfr, vitamin d metabolites and pth 1-84 in ckd. |
| title_full | Relationships among egfr, vitamin d metabolites and pth 1-84 in ckd. |
| title_fullStr | Relationships among egfr, vitamin d metabolites and pth 1-84 in ckd. |
| title_full_unstemmed | Relationships among egfr, vitamin d metabolites and pth 1-84 in ckd. |
| title_short | Relationships among egfr, vitamin d metabolites and pth 1-84 in ckd. |
| title_sort | relationships among egfr vitamin d metabolites and pth 1 84 in ckd |
| url | http://www.sciencedirect.com/science/article/pii/S2211913212005542 |
| work_keys_str_mv | AT kphelps relationshipsamongegfrvitamindmetabolitesandpth184inckd AT rmathew relationshipsamongegfrvitamindmetabolitesandpth184inckd AT kstote relationshipsamongegfrvitamindmetabolitesandpth184inckd AT lhewson relationshipsamongegfrvitamindmetabolitesandpth184inckd AT dhallenbeck relationshipsamongegfrvitamindmetabolitesandpth184inckd |