FAM46C Is an Interferon-Stimulated Gene That Inhibits Lentiviral Particle Production by Modulating Autophagy

FAM46C Is an Interferon-Stimulated Gene That Inhibits Lentiviral Particle Production by Modulating Autophagy

ABSTRACT FAM46C is a multiple myeloma (MM) tumor suppressor whose function is only starting to be elucidated. We recently showed that in MM cells FAM46C triggers apoptosis by inhibiting autophagy and altering intracellular trafficking and protein secretion. To date, both a physiological characteriza...

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Bibliographic Details
Main Authors: Marilena Mancino, Giancarlo Lai, Federica De Grossi, Alessandro Cuomo, Lara Manganaro, Giacomo M. Butta, Ivan Ferrari, Elisa Vicenzi, Guido Poli, Elisa Pesce, Stefania Oliveto, Stefano Biffo, Nicola Manfrini
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
FAM46C
TENT5C
HIV-1
autophagy
interferons
lentiviruses
Online Access:https://journals.asm.org/doi/10.1128/spectrum.05211-22

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