Role of gut microbiota in infectious and inflammatory diseases
Thousands of microorganisms compose the human gut microbiota, fighting pathogens in infectious diseases and inhibiting or inducing inflammation in different immunological contexts. The gut microbiome is a dynamic and complex ecosystem that helps in the proliferation, growth, and differentiation of e...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2023-03-01
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Series: | Frontiers in Microbiology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1098386/full |
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author | Miriãn Ferrão Maciel-Fiuza Miriãn Ferrão Maciel-Fiuza Miriãn Ferrão Maciel-Fiuza Miriãn Ferrão Maciel-Fiuza Guilherme Cerutti Muller Daniel Marques Stuart Campos Daniel Marques Stuart Campos Perpétua do Socorro Silva Costa Perpétua do Socorro Silva Costa Perpétua do Socorro Silva Costa Juliano Peruzzo Juliano Peruzzo Renan Rangel Bonamigo Renan Rangel Bonamigo Renan Rangel Bonamigo Tiago Veit Tiago Veit Fernanda Sales Luiz Vianna Fernanda Sales Luiz Vianna Fernanda Sales Luiz Vianna Fernanda Sales Luiz Vianna Fernanda Sales Luiz Vianna |
author_facet | Miriãn Ferrão Maciel-Fiuza Miriãn Ferrão Maciel-Fiuza Miriãn Ferrão Maciel-Fiuza Miriãn Ferrão Maciel-Fiuza Guilherme Cerutti Muller Daniel Marques Stuart Campos Daniel Marques Stuart Campos Perpétua do Socorro Silva Costa Perpétua do Socorro Silva Costa Perpétua do Socorro Silva Costa Juliano Peruzzo Juliano Peruzzo Renan Rangel Bonamigo Renan Rangel Bonamigo Renan Rangel Bonamigo Tiago Veit Tiago Veit Fernanda Sales Luiz Vianna Fernanda Sales Luiz Vianna Fernanda Sales Luiz Vianna Fernanda Sales Luiz Vianna Fernanda Sales Luiz Vianna |
author_sort | Miriãn Ferrão Maciel-Fiuza |
collection | DOAJ |
description | Thousands of microorganisms compose the human gut microbiota, fighting pathogens in infectious diseases and inhibiting or inducing inflammation in different immunological contexts. The gut microbiome is a dynamic and complex ecosystem that helps in the proliferation, growth, and differentiation of epithelial and immune cells to maintain intestinal homeostasis. Disorders that cause alteration of this microbiota lead to an imbalance in the host’s immune regulation. Growing evidence supports that the gut microbial community is associated with the development and progression of different infectious and inflammatory diseases. Therefore, understanding the interaction between intestinal microbiota and the modulation of the host’s immune system is fundamental to understanding the mechanisms involved in different pathologies, as well as for the search of new treatments. Here we review the main gut bacteria capable of impacting the immune response in different pathologies and we discuss the mechanisms by which this interaction between the immune system and the microbiota can alter disease outcomes. |
first_indexed | 2024-04-09T21:35:14Z |
format | Article |
id | doaj.art-e3cbda4c0b1d4407a5d6514a18d6d1ec |
institution | Directory Open Access Journal |
issn | 1664-302X |
language | English |
last_indexed | 2024-04-09T21:35:14Z |
publishDate | 2023-03-01 |
publisher | Frontiers Media S.A. |
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series | Frontiers in Microbiology |
spelling | doaj.art-e3cbda4c0b1d4407a5d6514a18d6d1ec2023-03-27T04:53:24ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-03-011410.3389/fmicb.2023.10983861098386Role of gut microbiota in infectious and inflammatory diseasesMiriãn Ferrão Maciel-Fiuza0Miriãn Ferrão Maciel-Fiuza1Miriãn Ferrão Maciel-Fiuza2Miriãn Ferrão Maciel-Fiuza3Guilherme Cerutti Muller4Daniel Marques Stuart Campos5Daniel Marques Stuart Campos6Perpétua do Socorro Silva Costa7Perpétua do Socorro Silva Costa8Perpétua do Socorro Silva Costa9Juliano Peruzzo10Juliano Peruzzo11Renan Rangel Bonamigo12Renan Rangel Bonamigo13Renan Rangel Bonamigo14Tiago Veit15Tiago Veit16Fernanda Sales Luiz Vianna17Fernanda Sales Luiz Vianna18Fernanda Sales Luiz Vianna19Fernanda Sales Luiz Vianna20Fernanda Sales Luiz Vianna21Postgraduate Program in Genetics and Molecular Biology, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, BrazilInstituto Nacional de Genética Médica Populacional, Porto Alegre, BrazilGenomics Medicine Laboratory, Center of Experimental Research, Hospital de Clínicas de Porto Alegre, Porto Alegre, BrazilLaboratory of Immunobiology and Immunogenetics, Department of Genetics, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, BrazilPostgraduate Program in Genetics and Molecular Biology, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, BrazilGenomics Medicine Laboratory, Center of Experimental Research, Hospital de Clínicas de Porto Alegre, Porto Alegre, BrazilLaboratory of Immunobiology and Immunogenetics, Department of Genetics, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, BrazilPostgraduate Program in Genetics and Molecular Biology, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, BrazilInstituto Nacional de Genética Médica Populacional, Porto Alegre, BrazilDepartment of Nursing, Universidade Federal do Maranhão, Imperatriz, BrazilDermatology Service of Hospital de Clínicas de Porto Alegre, Porto Alegre, BrazilPostgraduate Program in Medicine, Medical Sciences, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, BrazilDermatology Service of Hospital de Clínicas de Porto Alegre, Porto Alegre, BrazilPostgraduate Program in Medicine, Medical Sciences, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, BrazilPostgraduate Program in Pathology, Universidade Federal De Ciências Da Saúde de Porto Alegre, Porto Alegre, BrazilLaboratory of Immunobiology and Immunogenetics, Department of Genetics, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, BrazilDepartment of Microbiology, Immunology and Parasitology, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, BrazilPostgraduate Program in Genetics and Molecular Biology, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, BrazilInstituto Nacional de Genética Médica Populacional, Porto Alegre, BrazilGenomics Medicine Laboratory, Center of Experimental Research, Hospital de Clínicas de Porto Alegre, Porto Alegre, BrazilLaboratory of Immunobiology and Immunogenetics, Department of Genetics, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, BrazilPostgraduate Program in Medicine, Medical Sciences, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, BrazilThousands of microorganisms compose the human gut microbiota, fighting pathogens in infectious diseases and inhibiting or inducing inflammation in different immunological contexts. The gut microbiome is a dynamic and complex ecosystem that helps in the proliferation, growth, and differentiation of epithelial and immune cells to maintain intestinal homeostasis. Disorders that cause alteration of this microbiota lead to an imbalance in the host’s immune regulation. Growing evidence supports that the gut microbial community is associated with the development and progression of different infectious and inflammatory diseases. Therefore, understanding the interaction between intestinal microbiota and the modulation of the host’s immune system is fundamental to understanding the mechanisms involved in different pathologies, as well as for the search of new treatments. Here we review the main gut bacteria capable of impacting the immune response in different pathologies and we discuss the mechanisms by which this interaction between the immune system and the microbiota can alter disease outcomes.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1098386/fullgut microbiotamicrobiomeinfectious diseasesinflammationcytokinesimmune modulation |
spellingShingle | Miriãn Ferrão Maciel-Fiuza Miriãn Ferrão Maciel-Fiuza Miriãn Ferrão Maciel-Fiuza Miriãn Ferrão Maciel-Fiuza Guilherme Cerutti Muller Daniel Marques Stuart Campos Daniel Marques Stuart Campos Perpétua do Socorro Silva Costa Perpétua do Socorro Silva Costa Perpétua do Socorro Silva Costa Juliano Peruzzo Juliano Peruzzo Renan Rangel Bonamigo Renan Rangel Bonamigo Renan Rangel Bonamigo Tiago Veit Tiago Veit Fernanda Sales Luiz Vianna Fernanda Sales Luiz Vianna Fernanda Sales Luiz Vianna Fernanda Sales Luiz Vianna Fernanda Sales Luiz Vianna Role of gut microbiota in infectious and inflammatory diseases Frontiers in Microbiology gut microbiota microbiome infectious diseases inflammation cytokines immune modulation |
title | Role of gut microbiota in infectious and inflammatory diseases |
title_full | Role of gut microbiota in infectious and inflammatory diseases |
title_fullStr | Role of gut microbiota in infectious and inflammatory diseases |
title_full_unstemmed | Role of gut microbiota in infectious and inflammatory diseases |
title_short | Role of gut microbiota in infectious and inflammatory diseases |
title_sort | role of gut microbiota in infectious and inflammatory diseases |
topic | gut microbiota microbiome infectious diseases inflammation cytokines immune modulation |
url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1098386/full |
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