The histology of human right atrial tissue in patients with high-risk Obstructive Sleep Apnea and underlying cardiovascular disease: A pilot study
Background: Obstructive Sleep Apnea (OSA) results in intermittent hypoxia leading to atrial remodeling, which, among other things, facilitates development of atrial fibrillation. While much data exists on the macrostructural changes in cardiac physiology induced by OSA, there is a lack of studies lo...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-03-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906715000093 |
| _version_ | 1828531142961135616 |
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| author | Erik M. van Oosten Alexander H. Boag Kris Cunningham John Veinot Andrew Hamilton Dimitri Petsikas Darrin Payne Wilma M. Hopman Damian P. Redfearn WonJu Song Shawn Lamothe Shetuan Zhang Adrian Baranchuk |
| author_facet | Erik M. van Oosten Alexander H. Boag Kris Cunningham John Veinot Andrew Hamilton Dimitri Petsikas Darrin Payne Wilma M. Hopman Damian P. Redfearn WonJu Song Shawn Lamothe Shetuan Zhang Adrian Baranchuk |
| author_sort | Erik M. van Oosten |
| collection | DOAJ |
| description | Background: Obstructive Sleep Apnea (OSA) results in intermittent hypoxia leading to atrial remodeling, which, among other things, facilitates development of atrial fibrillation. While much data exists on the macrostructural changes in cardiac physiology induced by OSA, there is a lack of studies looking for histologic changes in human atrial tissue induced by OSA which might lead to the observed macrostructural changes.
Methods: A case control study was performed. Patients undergoing coronary artery bypass grafting (CABG) were evaluated for OSA and categorized as high-risk or low-risk. The right atrial tissue samples were obtained during CABG and both microscopic histological analysis and Sirius Red staining were performed.
Results: 18 patients undergoing CABG were included; 10 high-risk OSA and 8 low-risk OSA in evenly matched populations. No statistically significant difference between the two groups was observed in amount of myocytolysis (p = 0.181), nuclear hypertrophy (p = 0.671), myocardial inflammation (p = n/a), amyloid deposition (p = n/a), or presence of thrombi (p = n/a), as measured through routine H&E staining. As well, no statistically significant difference in interstitial and epicardial collagen was observed, as measured by Sirius Red staining (for total tissue: p = 0.619: for myocardium: p = 0.776).
Conclusions: In this pilot study there were no observable histological differences in human right atrial tissue from individuals at high- and low-risk for OSA. Further investigation would be required for more definitive results. |
| first_indexed | 2024-12-11T22:33:14Z |
| format | Article |
| id | doaj.art-e3cc7d3d3edd495da2fb73cf3cba7390 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-12-11T22:33:14Z |
| publishDate | 2015-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-e3cc7d3d3edd495da2fb73cf3cba73902022-12-22T00:48:04ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672015-03-016C717510.1016/j.ijcha.2015.01.008The histology of human right atrial tissue in patients with high-risk Obstructive Sleep Apnea and underlying cardiovascular disease: A pilot studyErik M. van Oosten0Alexander H. Boag1Kris Cunningham2John Veinot3Andrew Hamilton4Dimitri Petsikas5Darrin Payne6Wilma M. Hopman7Damian P. Redfearn8WonJu Song9Shawn Lamothe10Shetuan Zhang11Adrian Baranchuk12Queens University, Department of Medicine, 15 Arch Street, Kingston, Ontario K7L 3N6, CanadaQueens University, Department of Pathology, 15 Arch Street, Kingston, Ontario K7L 3N6, CanadaQueens University, Department of Pathology, 15 Arch Street, Kingston, Ontario K7L 3N6, CanadaUniversity of Ottawa, Department of Medicine, 451 Smyth Rd, Ottawa, Ontario K1H 8M5, CanadaQueens University, Department of Medicine, 15 Arch Street, Kingston, Ontario K7L 3N6, CanadaQueens University, Department of Medicine, 15 Arch Street, Kingston, Ontario K7L 3N6, CanadaQueens University, Department of Medicine, 15 Arch Street, Kingston, Ontario K7L 3N6, CanadaCardiology Department, Kingston General Hospital, Queen's University, 76 Stuart St, Kingston, Ontario K7L 2V7, CanadaQueens University, Department of Medicine, 15 Arch Street, Kingston, Ontario K7L 3N6, CanadaDepartment of Biomedical and Molecular Sciences, Botterell Hall, 18 Stuart Street, Kingston, Ontario K7L 3N6, CanadaDepartment of Biomedical and Molecular Sciences, Botterell Hall, 18 Stuart Street, Kingston, Ontario K7L 3N6, CanadaDepartment of Biomedical and Molecular Sciences, Botterell Hall, 18 Stuart Street, Kingston, Ontario K7L 3N6, CanadaQueens University, Department of Medicine, 15 Arch Street, Kingston, Ontario K7L 3N6, CanadaBackground: Obstructive Sleep Apnea (OSA) results in intermittent hypoxia leading to atrial remodeling, which, among other things, facilitates development of atrial fibrillation. While much data exists on the macrostructural changes in cardiac physiology induced by OSA, there is a lack of studies looking for histologic changes in human atrial tissue induced by OSA which might lead to the observed macrostructural changes. Methods: A case control study was performed. Patients undergoing coronary artery bypass grafting (CABG) were evaluated for OSA and categorized as high-risk or low-risk. The right atrial tissue samples were obtained during CABG and both microscopic histological analysis and Sirius Red staining were performed. Results: 18 patients undergoing CABG were included; 10 high-risk OSA and 8 low-risk OSA in evenly matched populations. No statistically significant difference between the two groups was observed in amount of myocytolysis (p = 0.181), nuclear hypertrophy (p = 0.671), myocardial inflammation (p = n/a), amyloid deposition (p = n/a), or presence of thrombi (p = n/a), as measured through routine H&E staining. As well, no statistically significant difference in interstitial and epicardial collagen was observed, as measured by Sirius Red staining (for total tissue: p = 0.619: for myocardium: p = 0.776). Conclusions: In this pilot study there were no observable histological differences in human right atrial tissue from individuals at high- and low-risk for OSA. Further investigation would be required for more definitive results.http://www.sciencedirect.com/science/article/pii/S2352906715000093Obstructive Sleep ApneaHuman atrial tissueHistological analysisMyocardial fibrosis |
| spellingShingle | Erik M. van Oosten Alexander H. Boag Kris Cunningham John Veinot Andrew Hamilton Dimitri Petsikas Darrin Payne Wilma M. Hopman Damian P. Redfearn WonJu Song Shawn Lamothe Shetuan Zhang Adrian Baranchuk The histology of human right atrial tissue in patients with high-risk Obstructive Sleep Apnea and underlying cardiovascular disease: A pilot study International Journal of Cardiology: Heart & Vasculature Obstructive Sleep Apnea Human atrial tissue Histological analysis Myocardial fibrosis |
| title | The histology of human right atrial tissue in patients with high-risk Obstructive Sleep Apnea and underlying cardiovascular disease: A pilot study |
| title_full | The histology of human right atrial tissue in patients with high-risk Obstructive Sleep Apnea and underlying cardiovascular disease: A pilot study |
| title_fullStr | The histology of human right atrial tissue in patients with high-risk Obstructive Sleep Apnea and underlying cardiovascular disease: A pilot study |
| title_full_unstemmed | The histology of human right atrial tissue in patients with high-risk Obstructive Sleep Apnea and underlying cardiovascular disease: A pilot study |
| title_short | The histology of human right atrial tissue in patients with high-risk Obstructive Sleep Apnea and underlying cardiovascular disease: A pilot study |
| title_sort | histology of human right atrial tissue in patients with high risk obstructive sleep apnea and underlying cardiovascular disease a pilot study |
| topic | Obstructive Sleep Apnea Human atrial tissue Histological analysis Myocardial fibrosis |
| url | http://www.sciencedirect.com/science/article/pii/S2352906715000093 |
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