Low diagnostic accuracy and inter-observer agreement on CT and MRI in diagnosis of spinal fractures in multiple myeloma
Skeletal disease is common in multiple myeloma. We investigated the inter-observer agreement and diagnostic accuracy of spinal fractures diagnosed by computer tomography (CT) and magnetic resonance imaging (MRI) from 12 myeloma patients. Two radiologists independently assessed the images. CT, MRI, a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Hematology Reports |
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| Online Access: | https://www.pagepress.org/journals/index.php/hr/article/view/9037 |
| _version_ | 1797936715011194880 |
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| author | Viktor Dalen Anne-Sofie Vegsgaard Olsen Claude-Pierre Jerome Jonn-Terje Geitung Anders E.A. Dahm |
| author_facet | Viktor Dalen Anne-Sofie Vegsgaard Olsen Claude-Pierre Jerome Jonn-Terje Geitung Anders E.A. Dahm |
| author_sort | Viktor Dalen |
| collection | DOAJ |
| description | Skeletal disease is common in multiple myeloma. We investigated the inter-observer agreement and diagnostic accuracy of spinal fractures diagnosed by computer tomography (CT) and magnetic resonance imaging (MRI) from 12 myeloma patients. Two radiologists independently assessed the images. CT, MRI, and other images were combined to a gold standard. The inter-observer agreement was assessed with Cohen’s kappa. Radiologist 1 diagnosed 20 malignant spinal fractures on CT and 26 on MRI, while radiologist 2 diagnosed 12 malignant spinal fractures on CT and 22 on MRI. In comparison the gold standard diagnosed 10 malignant spinal fractures. The sensitivity for malignant fractures varied from 0.5 to 1 for CT and MRI, and the specificity varied from 0.17 to 0.67. On MRI, the specificity for malignant spinal fractures was 0.17 for both radiologists. The inter-observer agreement for malignant spinal fractures on CT was -0.42 (Cohen’s kappa) and -0.13 for MRI, while for osteoporotic fractures it was -0.24 for CT and 0.53 for MRI. We conclude that malignant spinal fractures were over-diagnosed on CT and MRI. The inter-observer agreement was extremely poor. |
| first_indexed | 2024-04-10T18:34:41Z |
| format | Article |
| id | doaj.art-e3ce0caa9a1e4d7fb1615b9f18528529 |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T18:34:41Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-e3ce0caa9a1e4d7fb1615b9f185285292023-02-02T02:20:47ZengMDPI AGHematology Reports2038-83222038-83302021-10-0113310.4081/hr.2021.9037Low diagnostic accuracy and inter-observer agreement on CT and MRI in diagnosis of spinal fractures in multiple myelomaViktor Dalen0Anne-Sofie Vegsgaard Olsen1Claude-Pierre Jerome2Jonn-Terje Geitung3Anders E.A. Dahm4Medical Faculty, University of OsloMedical Faculty, University of OsloDepartment of Radiology, Akershus University Hospital, LørenskogDepartment of Radiology, Akershus University Hospital, Lørenskog; Institute of Clinical Medicine, University of OsloInstitute of Clinical Medicine, University of Oslo; Department of Haematology, Akershus University Hospital, LørenskogSkeletal disease is common in multiple myeloma. We investigated the inter-observer agreement and diagnostic accuracy of spinal fractures diagnosed by computer tomography (CT) and magnetic resonance imaging (MRI) from 12 myeloma patients. Two radiologists independently assessed the images. CT, MRI, and other images were combined to a gold standard. The inter-observer agreement was assessed with Cohen’s kappa. Radiologist 1 diagnosed 20 malignant spinal fractures on CT and 26 on MRI, while radiologist 2 diagnosed 12 malignant spinal fractures on CT and 22 on MRI. In comparison the gold standard diagnosed 10 malignant spinal fractures. The sensitivity for malignant fractures varied from 0.5 to 1 for CT and MRI, and the specificity varied from 0.17 to 0.67. On MRI, the specificity for malignant spinal fractures was 0.17 for both radiologists. The inter-observer agreement for malignant spinal fractures on CT was -0.42 (Cohen’s kappa) and -0.13 for MRI, while for osteoporotic fractures it was -0.24 for CT and 0.53 for MRI. We conclude that malignant spinal fractures were over-diagnosed on CT and MRI. The inter-observer agreement was extremely poor.https://www.pagepress.org/journals/index.php/hr/article/view/9037Diagnostic specificitymalignant fracturesosteoporotic fracturesdiagnostic imaginghaematologymultiple myeloma |
| spellingShingle | Viktor Dalen Anne-Sofie Vegsgaard Olsen Claude-Pierre Jerome Jonn-Terje Geitung Anders E.A. Dahm Low diagnostic accuracy and inter-observer agreement on CT and MRI in diagnosis of spinal fractures in multiple myeloma Hematology Reports Diagnostic specificity malignant fractures osteoporotic fractures diagnostic imaging haematology multiple myeloma |
| title | Low diagnostic accuracy and inter-observer agreement on CT and MRI in diagnosis of spinal fractures in multiple myeloma |
| title_full | Low diagnostic accuracy and inter-observer agreement on CT and MRI in diagnosis of spinal fractures in multiple myeloma |
| title_fullStr | Low diagnostic accuracy and inter-observer agreement on CT and MRI in diagnosis of spinal fractures in multiple myeloma |
| title_full_unstemmed | Low diagnostic accuracy and inter-observer agreement on CT and MRI in diagnosis of spinal fractures in multiple myeloma |
| title_short | Low diagnostic accuracy and inter-observer agreement on CT and MRI in diagnosis of spinal fractures in multiple myeloma |
| title_sort | low diagnostic accuracy and inter observer agreement on ct and mri in diagnosis of spinal fractures in multiple myeloma |
| topic | Diagnostic specificity malignant fractures osteoporotic fractures diagnostic imaging haematology multiple myeloma |
| url | https://www.pagepress.org/journals/index.php/hr/article/view/9037 |
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