Exosomal circWDR62 promotes temozolomide resistance and malignant progression through regulation of the miR-370-3p/MGMT axis in glioma

Exosomal circWDR62 promotes temozolomide resistance and malignant progression through regulation of the miR-370-3p/MGMT axis in glioma

Abstract Exosome-mediated delivery of circular RNAs (circRNAs) is implicated in cancer progression. However, the role of exosomal circRNAs in the chemotherapy resistance of tumours remains poorly understood. Here we identified a novel circRNA, circWDR62. It was found that circWDR62 expression was up...

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Bibliographic Details
Main Authors: Xiuchao Geng, Yuhao Zhang, Xiaomeng Lin, Zhaomu Zeng, Jun Hu, Liangchao Hao, Jianglong Xu, Xinjuan Wang, Hong Wang, Qiang Li
Format: Article
Language:English
Published: Nature Publishing Group 2022-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05056-5

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