Visual Map Shifts based on Whisker-Guided Cues in the Young Mouse Visual Cortex
Mice navigate nearby space using their vision and whiskers, and young mice learn to integrate these heterogeneous inputs in perceptual space. We found that cortical responses were depressed in the primary visual cortex of young mice after wearing a monocular prism. This depression was uniformly obse...
| Autors principals: | , , , , , , |
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| Format: | Article |
| Idioma: | English |
| Publicat: |
Elsevier
2013-12-01
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| Col·lecció: | Cell Reports |
| Accés en línia: | http://www.sciencedirect.com/science/article/pii/S2211124713006554 |
| _version_ | 1828758476865667072 |
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| author | Kohei Yoshitake Hiroaki Tsukano Manavu Tohmi Seiji Komagata Ryuichi Hishida Takeshi Yagi Katsuei Shibuki |
| author_facet | Kohei Yoshitake Hiroaki Tsukano Manavu Tohmi Seiji Komagata Ryuichi Hishida Takeshi Yagi Katsuei Shibuki |
| author_sort | Kohei Yoshitake |
| collection | DOAJ |
| description | Mice navigate nearby space using their vision and whiskers, and young mice learn to integrate these heterogeneous inputs in perceptual space. We found that cortical responses were depressed in the primary visual cortex of young mice after wearing a monocular prism. This depression was uniformly observed in the primary visual cortex and was eliminated by whisker trimming or lesions in the posterior parietal cortex. Compensatory visual map shifts of responses elicited via the eye that had worn the prism were also observed. As a result, cortical responses elicited via each eye were clearly separated when a visual stimulus was placed in front of the mice. A comparison of response areas before and after prism wearing indicated that the map shifts were produced by depression with spatial eccentricity. Visual map shifts based on whisker-guided cues may serve as a model for investigating the cellular and molecular mechanisms underlying higher sensory integration in the mammalian brain. |
| first_indexed | 2024-12-11T00:42:34Z |
| format | Article |
| id | doaj.art-e3d08f74b85f42ec9b48a3832b9fe9a1 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-11T00:42:34Z |
| publishDate | 2013-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-e3d08f74b85f42ec9b48a3832b9fe9a12022-12-22T01:26:52ZengElsevierCell Reports2211-12472013-12-01551365137410.1016/j.celrep.2013.11.006Visual Map Shifts based on Whisker-Guided Cues in the Young Mouse Visual CortexKohei Yoshitake0Hiroaki Tsukano1Manavu Tohmi2Seiji Komagata3Ryuichi Hishida4Takeshi Yagi5Katsuei Shibuki6Department of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahi-machi, Chuo-ku, Niigata 951-8585, JapanDepartment of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahi-machi, Chuo-ku, Niigata 951-8585, JapanDepartment of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahi-machi, Chuo-ku, Niigata 951-8585, JapanDepartment of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahi-machi, Chuo-ku, Niigata 951-8585, JapanDepartment of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahi-machi, Chuo-ku, Niigata 951-8585, JapanKOKORO-Biology Group, Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, JapanDepartment of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahi-machi, Chuo-ku, Niigata 951-8585, JapanMice navigate nearby space using their vision and whiskers, and young mice learn to integrate these heterogeneous inputs in perceptual space. We found that cortical responses were depressed in the primary visual cortex of young mice after wearing a monocular prism. This depression was uniformly observed in the primary visual cortex and was eliminated by whisker trimming or lesions in the posterior parietal cortex. Compensatory visual map shifts of responses elicited via the eye that had worn the prism were also observed. As a result, cortical responses elicited via each eye were clearly separated when a visual stimulus was placed in front of the mice. A comparison of response areas before and after prism wearing indicated that the map shifts were produced by depression with spatial eccentricity. Visual map shifts based on whisker-guided cues may serve as a model for investigating the cellular and molecular mechanisms underlying higher sensory integration in the mammalian brain.http://www.sciencedirect.com/science/article/pii/S2211124713006554 |
| spellingShingle | Kohei Yoshitake Hiroaki Tsukano Manavu Tohmi Seiji Komagata Ryuichi Hishida Takeshi Yagi Katsuei Shibuki Visual Map Shifts based on Whisker-Guided Cues in the Young Mouse Visual Cortex Cell Reports |
| title | Visual Map Shifts based on Whisker-Guided Cues in the Young Mouse Visual Cortex |
| title_full | Visual Map Shifts based on Whisker-Guided Cues in the Young Mouse Visual Cortex |
| title_fullStr | Visual Map Shifts based on Whisker-Guided Cues in the Young Mouse Visual Cortex |
| title_full_unstemmed | Visual Map Shifts based on Whisker-Guided Cues in the Young Mouse Visual Cortex |
| title_short | Visual Map Shifts based on Whisker-Guided Cues in the Young Mouse Visual Cortex |
| title_sort | visual map shifts based on whisker guided cues in the young mouse visual cortex |
| url | http://www.sciencedirect.com/science/article/pii/S2211124713006554 |
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