Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis

Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis

Doublecortin-like kinase 1 (DCLK1) is a functional serine/threonine (S/T)-kinase and a member of the doublecortin family of proteins which are characterized by their ability to bind to microtubules (MTs). DCLK1 is a proposed cancer driver gene, and its upregulation is associated with poor overall su...

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Bibliographic Details
Main Authors: Annalisa L. E. Carli, Joshua M. Hardy, Hanadi Hoblos, Matthias Ernst, Isabelle S. Lucet, Michael Buchert
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomedicines
Subjects:
DCLK1
DCX
crystal structure
cryo-EM
missense mutations
cancer
Online Access:https://www.mdpi.com/2227-9059/11/3/990

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