Therapeutic potential and recent delivery systems of berberine: A wonder molecule
Currently, phytoconstituents have been emerged as a scientific interest in discovering novel therapeutics against numerous diseases. Berberine is a bioactive alkaloid, historically reported for pharmacological actions such as diuretic, antidiarrheal, antimicrobial and antiprotozoal etc. Scientific e...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619304414 |
| _version_ | 1818406161612800000 |
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| author | Marina Raju Yogesh A. Kulkarni Sarika Wairkar |
| author_facet | Marina Raju Yogesh A. Kulkarni Sarika Wairkar |
| author_sort | Marina Raju |
| collection | DOAJ |
| description | Currently, phytoconstituents have been emerged as a scientific interest in discovering novel therapeutics against numerous diseases. Berberine is a bioactive alkaloid, historically reported for pharmacological actions such as diuretic, antidiarrheal, antimicrobial and antiprotozoal etc. Scientific evidences exhibit its versatile therapeutic uses against several metabolic, cardiac and neurologic disorders. Despite of valuable properties, the clinical use of berberine has been limited due to its poor intestinal absorption, low bioavailability and limited penetration. Therefore, it demands development of efficient delivery systems to overcome its limitations. This article not only focuses on mode of actions, physicochemical, pharmacokinetic and pharmacodynamic properties of berberine, but also highlights the attempt made so far to deliver it through conventional and novel formulations. Here, a structured division has been briefed, rendering conventional, lipid-based, polymeric-based and miscellaneous berberine formulation. Although extensive in-vitro and preclinical studies have been reported, commercial exploitation of berberine needs in-depth clinical safety and efficacy data. |
| first_indexed | 2024-12-14T09:07:33Z |
| format | Article |
| id | doaj.art-e3d17d2f84de4012bb1b93ed1468a317 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T09:07:33Z |
| publishDate | 2019-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-e3d17d2f84de4012bb1b93ed1468a3172022-12-21T23:08:40ZengElsevierJournal of Functional Foods1756-46462019-10-0161Therapeutic potential and recent delivery systems of berberine: A wonder moleculeMarina Raju0Yogesh A. Kulkarni1Sarika Wairkar2Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, IndiaShobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, IndiaCorresponding author.; Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, IndiaCurrently, phytoconstituents have been emerged as a scientific interest in discovering novel therapeutics against numerous diseases. Berberine is a bioactive alkaloid, historically reported for pharmacological actions such as diuretic, antidiarrheal, antimicrobial and antiprotozoal etc. Scientific evidences exhibit its versatile therapeutic uses against several metabolic, cardiac and neurologic disorders. Despite of valuable properties, the clinical use of berberine has been limited due to its poor intestinal absorption, low bioavailability and limited penetration. Therefore, it demands development of efficient delivery systems to overcome its limitations. This article not only focuses on mode of actions, physicochemical, pharmacokinetic and pharmacodynamic properties of berberine, but also highlights the attempt made so far to deliver it through conventional and novel formulations. Here, a structured division has been briefed, rendering conventional, lipid-based, polymeric-based and miscellaneous berberine formulation. Although extensive in-vitro and preclinical studies have been reported, commercial exploitation of berberine needs in-depth clinical safety and efficacy data.http://www.sciencedirect.com/science/article/pii/S1756464619304414BerberinePharmacokineticTherapeutic actionsDosage formsNovel drug delivery |
| spellingShingle | Marina Raju Yogesh A. Kulkarni Sarika Wairkar Therapeutic potential and recent delivery systems of berberine: A wonder molecule Journal of Functional Foods Berberine Pharmacokinetic Therapeutic actions Dosage forms Novel drug delivery |
| title | Therapeutic potential and recent delivery systems of berberine: A wonder molecule |
| title_full | Therapeutic potential and recent delivery systems of berberine: A wonder molecule |
| title_fullStr | Therapeutic potential and recent delivery systems of berberine: A wonder molecule |
| title_full_unstemmed | Therapeutic potential and recent delivery systems of berberine: A wonder molecule |
| title_short | Therapeutic potential and recent delivery systems of berberine: A wonder molecule |
| title_sort | therapeutic potential and recent delivery systems of berberine a wonder molecule |
| topic | Berberine Pharmacokinetic Therapeutic actions Dosage forms Novel drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619304414 |
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