Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapy
Recent studies have highlighted a possible correlation between microbiota composition and the pathogenesis of various oncological diseases. Also, many bacterial groups are now directly or indirectly associated with the capability of stimulating or inhibiting carcinogenic pathways. However, little is...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Pathology and Oncology Research |
| Subjects: | |
| Online Access: | https://www.por-journal.com/articles/10.3389/pore.2023.1611300/full |
| _version_ | 1797222411120148480 |
|---|---|
| author | Massimiliano Cazzaniga Giordano Bruno Zonzini Francesco Di Pierro Francesco Di Pierro Chiara Maria Palazzi Marco Cardinali Alexander Bertuccioli |
| author_facet | Massimiliano Cazzaniga Giordano Bruno Zonzini Francesco Di Pierro Francesco Di Pierro Chiara Maria Palazzi Marco Cardinali Alexander Bertuccioli |
| author_sort | Massimiliano Cazzaniga |
| collection | DOAJ |
| description | Recent studies have highlighted a possible correlation between microbiota composition and the pathogenesis of various oncological diseases. Also, many bacterial groups are now directly or indirectly associated with the capability of stimulating or inhibiting carcinogenic pathways. However, little is known about the importance and impact of microbiota patterns related to the efficacy and toxicity of cancer treatments. We have recently begun to understand how oncological therapies and the microbiota are closely interconnected and could influence each other. Chemotherapy effectiveness, for example, appears to be strongly influenced by the presence of some microorganisms capable of modulating the pharmacokinetics and pharmacodynamics of the compounds used, thus varying the real response and therefore the efficacy of the oncological treatment. Similarly, chemotherapeutic agents can modulate the microbiota with variations that could facilitate or avoid the onset of important side effects. This finding has or could have considerable relevance as it is possible that our ability to modulate and modify the microbial structure before, during, and after treatment could influence all the clinical parameters related to pharmacological treatments and, eventually, the prognosis of the disease. |
| first_indexed | 2024-04-24T13:20:54Z |
| format | Article |
| id | doaj.art-e3d345b9265e48cf87b427dcc32b5dd4 |
| institution | Directory Open Access Journal |
| issn | 1532-2807 |
| language | English |
| last_indexed | 2024-04-24T13:20:54Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Pathology and Oncology Research |
| spelling | doaj.art-e3d345b9265e48cf87b427dcc32b5dd42024-04-04T16:17:28ZengFrontiers Media S.A.Pathology and Oncology Research1532-28072023-08-012910.3389/pore.2023.16113001611300Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapyMassimiliano Cazzaniga0Giordano Bruno Zonzini1Francesco Di Pierro2Francesco Di Pierro3Chiara Maria Palazzi4Marco Cardinali5Alexander Bertuccioli6Scientific & Research Department, Velleja Research, Milano, ItalyDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, ItalyScientific & Research Department, Velleja Research, Milano, ItalyDepartment of Medicine and Surgery, University of Insurbia, Varese, ItalyAssociazione Italiana Fitness e Medicina, Ravenna, ItalyDepartment of Internal Medicine, Infermi Hospital, Azienda Unità Sanitaria Locale Romagna, Rimini, ItalyDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, ItalyRecent studies have highlighted a possible correlation between microbiota composition and the pathogenesis of various oncological diseases. Also, many bacterial groups are now directly or indirectly associated with the capability of stimulating or inhibiting carcinogenic pathways. However, little is known about the importance and impact of microbiota patterns related to the efficacy and toxicity of cancer treatments. We have recently begun to understand how oncological therapies and the microbiota are closely interconnected and could influence each other. Chemotherapy effectiveness, for example, appears to be strongly influenced by the presence of some microorganisms capable of modulating the pharmacokinetics and pharmacodynamics of the compounds used, thus varying the real response and therefore the efficacy of the oncological treatment. Similarly, chemotherapeutic agents can modulate the microbiota with variations that could facilitate or avoid the onset of important side effects. This finding has or could have considerable relevance as it is possible that our ability to modulate and modify the microbial structure before, during, and after treatment could influence all the clinical parameters related to pharmacological treatments and, eventually, the prognosis of the disease.https://www.por-journal.com/articles/10.3389/pore.2023.1611300/fullmicrobiotachemotherapyoncologytoxicitymicrobiome |
| spellingShingle | Massimiliano Cazzaniga Giordano Bruno Zonzini Francesco Di Pierro Francesco Di Pierro Chiara Maria Palazzi Marco Cardinali Alexander Bertuccioli Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapy Pathology and Oncology Research microbiota chemotherapy oncology toxicity microbiome |
| title | Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapy |
| title_full | Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapy |
| title_fullStr | Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapy |
| title_full_unstemmed | Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapy |
| title_short | Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapy |
| title_sort | influence of the microbiota on the effectiveness and toxicity of oncological therapies with a focus on chemotherapy |
| topic | microbiota chemotherapy oncology toxicity microbiome |
| url | https://www.por-journal.com/articles/10.3389/pore.2023.1611300/full |
| work_keys_str_mv | AT massimilianocazzaniga influenceofthemicrobiotaontheeffectivenessandtoxicityofoncologicaltherapieswithafocusonchemotherapy AT giordanobrunozonzini influenceofthemicrobiotaontheeffectivenessandtoxicityofoncologicaltherapieswithafocusonchemotherapy AT francescodipierro influenceofthemicrobiotaontheeffectivenessandtoxicityofoncologicaltherapieswithafocusonchemotherapy AT francescodipierro influenceofthemicrobiotaontheeffectivenessandtoxicityofoncologicaltherapieswithafocusonchemotherapy AT chiaramariapalazzi influenceofthemicrobiotaontheeffectivenessandtoxicityofoncologicaltherapieswithafocusonchemotherapy AT marcocardinali influenceofthemicrobiotaontheeffectivenessandtoxicityofoncologicaltherapieswithafocusonchemotherapy AT alexanderbertuccioli influenceofthemicrobiotaontheeffectivenessandtoxicityofoncologicaltherapieswithafocusonchemotherapy |