Immediate hypersensitivity to polyethylene glycols in unrelated products: when standardization in the nomenclature of the components of drugs, cosmetics, and food becomes necessary
Abstract Background Polyethylene glycols (PEGs) and their derivatives are non-ionic polymers of ethylene oxide commercially available with numerous synonyms, such as macrogol, oxyethylene polymer, and laureth-9. Although these polymers are usually safe, mild to life-threatening immediate-type hypers...
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | Allergy, Asthma & Clinical Immunology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13223-019-0327-4 |
| _version_ | 1811273518556381184 |
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| author | Vicente Jover Cerdá Ramón Rodríguez Pacheco Joan Doménech Witek Francisco Manuel Marco de la Calle María Luz de la Sen Fernández |
| author_facet | Vicente Jover Cerdá Ramón Rodríguez Pacheco Joan Doménech Witek Francisco Manuel Marco de la Calle María Luz de la Sen Fernández |
| author_sort | Vicente Jover Cerdá |
| collection | DOAJ |
| description | Abstract Background Polyethylene glycols (PEGs) and their derivatives are non-ionic polymers of ethylene oxide commercially available with numerous synonyms, such as macrogol, oxyethylene polymer, and laureth-9. Although these polymers are usually safe, mild to life-threatening immediate-type hypersensitivity reactions have been reported. Nevertheless, awareness about their allergic potential is minimal due to the non-standardization of their nomenclature. Case presentation We present the case of a 29-years-old woman who developed several local and systemic type I hypersensitivity reactions including a severe anaphylactic reaction to different pharmacologic and cosmetic products whose excipients included PEG. Prick tests and basophil activation tests were performed to several pharmacological and cosmetic products, but only those containing PEGs and their derivatives were positive. The patient was diagnosed with immediate hypersensitivity IgE-mediated to PEGs and its derivatives. Conclusions Standardization of the terminology used to describe the presence of PEGs in products would help patients to identify them clearly and unequivocally and thus avoid the development of hypersensitivity reactions. It is also recommended studying PEG allergy in reactions to products containing PEGs, once allergy to the active ingredients has been excluded and in reactions to multiple unrelated drugs. Clinical study protocol number PI2018/29 (registered on 24 September 2018) |
| first_indexed | 2024-04-12T23:00:41Z |
| format | Article |
| id | doaj.art-e3d35a15d2c34a7c9356300ee0cd9f74 |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-04-12T23:00:41Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-e3d35a15d2c34a7c9356300ee0cd9f742022-12-22T03:13:04ZengBMCAllergy, Asthma & Clinical Immunology1710-14922019-02-011511510.1186/s13223-019-0327-4Immediate hypersensitivity to polyethylene glycols in unrelated products: when standardization in the nomenclature of the components of drugs, cosmetics, and food becomes necessaryVicente Jover Cerdá0Ramón Rodríguez Pacheco1Joan Doménech Witek2Francisco Manuel Marco de la Calle3María Luz de la Sen Fernández4Sección de Alergología, Hospital General Universitario de EldaSección de Alergología, Hospital General Universitario de EldaSección de Alergología, Hospital General Universitario de EldaServicio de Análisis Clínicos e Inmunología, Hospital General Universitario de AlicanteServicio de Análisis Clínicos e Inmunología, Hospital General Universitario de AlicanteAbstract Background Polyethylene glycols (PEGs) and their derivatives are non-ionic polymers of ethylene oxide commercially available with numerous synonyms, such as macrogol, oxyethylene polymer, and laureth-9. Although these polymers are usually safe, mild to life-threatening immediate-type hypersensitivity reactions have been reported. Nevertheless, awareness about their allergic potential is minimal due to the non-standardization of their nomenclature. Case presentation We present the case of a 29-years-old woman who developed several local and systemic type I hypersensitivity reactions including a severe anaphylactic reaction to different pharmacologic and cosmetic products whose excipients included PEG. Prick tests and basophil activation tests were performed to several pharmacological and cosmetic products, but only those containing PEGs and their derivatives were positive. The patient was diagnosed with immediate hypersensitivity IgE-mediated to PEGs and its derivatives. Conclusions Standardization of the terminology used to describe the presence of PEGs in products would help patients to identify them clearly and unequivocally and thus avoid the development of hypersensitivity reactions. It is also recommended studying PEG allergy in reactions to products containing PEGs, once allergy to the active ingredients has been excluded and in reactions to multiple unrelated drugs. Clinical study protocol number PI2018/29 (registered on 24 September 2018)http://link.springer.com/article/10.1186/s13223-019-0327-4Excipient allergyAnaphylaxisBasophil activation testHypersensitivityPolyethylene glycol |
| spellingShingle | Vicente Jover Cerdá Ramón Rodríguez Pacheco Joan Doménech Witek Francisco Manuel Marco de la Calle María Luz de la Sen Fernández Immediate hypersensitivity to polyethylene glycols in unrelated products: when standardization in the nomenclature of the components of drugs, cosmetics, and food becomes necessary Allergy, Asthma & Clinical Immunology Excipient allergy Anaphylaxis Basophil activation test Hypersensitivity Polyethylene glycol |
| title | Immediate hypersensitivity to polyethylene glycols in unrelated products: when standardization in the nomenclature of the components of drugs, cosmetics, and food becomes necessary |
| title_full | Immediate hypersensitivity to polyethylene glycols in unrelated products: when standardization in the nomenclature of the components of drugs, cosmetics, and food becomes necessary |
| title_fullStr | Immediate hypersensitivity to polyethylene glycols in unrelated products: when standardization in the nomenclature of the components of drugs, cosmetics, and food becomes necessary |
| title_full_unstemmed | Immediate hypersensitivity to polyethylene glycols in unrelated products: when standardization in the nomenclature of the components of drugs, cosmetics, and food becomes necessary |
| title_short | Immediate hypersensitivity to polyethylene glycols in unrelated products: when standardization in the nomenclature of the components of drugs, cosmetics, and food becomes necessary |
| title_sort | immediate hypersensitivity to polyethylene glycols in unrelated products when standardization in the nomenclature of the components of drugs cosmetics and food becomes necessary |
| topic | Excipient allergy Anaphylaxis Basophil activation test Hypersensitivity Polyethylene glycol |
| url | http://link.springer.com/article/10.1186/s13223-019-0327-4 |
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