β-Arrestin 2 Promotes Hepatocyte Apoptosis by Inhibiting Akt Pathway in Alcoholic Liver Disease

β-Arrestin 2 Promotes Hepatocyte Apoptosis by Inhibiting Akt Pathway in Alcoholic Liver Disease

Alcoholic liver disease (ALD) is a complex process that includes a wide range of hepatic lesions, from steatosis to cirrhosis, and even hepatocellular carcinoma (HCC). Accumulating evidence shows that the cytotoxic effects of ethanol metabolism lead to cell apoptosis and necrosis in ALD. Recently, s...

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Bibliographic Details
Main Authors: Ying-Yin Sun, Yu-Xin Zhao, Xiao-Feng Li, Cheng Huang, Xiao-Ming Meng, Jun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
alcoholic liver disease (ALD)
β-arrestin 2 (Arrb2)
hepatocyte
apoptosis
Akt
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01031/full

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