Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries
Epidemiological studies have shown associations between polyphenol-rich fruit intake and bone health, and preclinical studies have shown that blueberries improve bone health. To determine the genotype and dose of blueberries that are effective in ameliorating age-related bone loss, a multi-instituti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/5/1136 |
| _version_ | 1797601293978566656 |
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| author | Connie M. Weaver Mario G. Ferruzzi Maria Maiz Dennis P. Cladis Cindy H. Nakatsu George P. McCabe Mary Ann Lila |
| author_facet | Connie M. Weaver Mario G. Ferruzzi Maria Maiz Dennis P. Cladis Cindy H. Nakatsu George P. McCabe Mary Ann Lila |
| author_sort | Connie M. Weaver |
| collection | DOAJ |
| description | Epidemiological studies have shown associations between polyphenol-rich fruit intake and bone health, and preclinical studies have shown that blueberries improve bone health. To determine the genotype and dose of blueberries that are effective in ameliorating age-related bone loss, a multi-institutional team of investigators performed in vitro, preclinical, and clinical studies on blueberry varieties that differed in flavonoid profiles. Principal component analysis was used to select blueberry genotypes that varied in anthocyanin profiles. Total phenolic content did not predict the bioavailability of polyphenolic compounds in rats. A range in bioavailability was observed in individual polyphenolic compounds across genotypes. Both alpha and beta diversity analyses indicated that gut microbiome profiles varied with blueberry dose in rats. Additionally, the identification of specific taxa, such as Prevotellaceae_UCG-001 and Coriobacteriales, increasing after blueberry consumption adds to the mounting evidence of their role in polyphenol metabolism. All of the sources of variation can inform blueberry breeding practices to influence precision nutrition. |
| first_indexed | 2024-03-11T03:59:59Z |
| format | Article |
| id | doaj.art-e3d5bf6a366044cdafde22c03f850521 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T03:59:59Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-e3d5bf6a366044cdafde22c03f8505212023-11-18T00:16:09ZengMDPI AGAntioxidants2076-39212023-05-01125113610.3390/antiox12051136Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of BlueberriesConnie M. Weaver0Mario G. Ferruzzi1Maria Maiz2Dennis P. Cladis3Cindy H. Nakatsu4George P. McCabe5Mary Ann Lila6School of Exercise and Nutritional Science, San Diego State University, San Diego, CA 92182, USAArkansas Children’s Nutrition Center, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USADepartment of Nutrition Science, Purdue University, West Lafayette, IN 47907, USADepartment of Food Science and Technology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USADepartment of Agronomy, Purdue University, West Lafayette, IN 47907, USADepartment of Statistics, Purdue University, West Lafayette, IN 47907, USAPlants for Human Health Institute, Department of Food Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis, NC 28081, USAEpidemiological studies have shown associations between polyphenol-rich fruit intake and bone health, and preclinical studies have shown that blueberries improve bone health. To determine the genotype and dose of blueberries that are effective in ameliorating age-related bone loss, a multi-institutional team of investigators performed in vitro, preclinical, and clinical studies on blueberry varieties that differed in flavonoid profiles. Principal component analysis was used to select blueberry genotypes that varied in anthocyanin profiles. Total phenolic content did not predict the bioavailability of polyphenolic compounds in rats. A range in bioavailability was observed in individual polyphenolic compounds across genotypes. Both alpha and beta diversity analyses indicated that gut microbiome profiles varied with blueberry dose in rats. Additionally, the identification of specific taxa, such as Prevotellaceae_UCG-001 and Coriobacteriales, increasing after blueberry consumption adds to the mounting evidence of their role in polyphenol metabolism. All of the sources of variation can inform blueberry breeding practices to influence precision nutrition.https://www.mdpi.com/2076-3921/12/5/1136blueberriespolyphenolsanthocyaninsprecision nutrition |
| spellingShingle | Connie M. Weaver Mario G. Ferruzzi Maria Maiz Dennis P. Cladis Cindy H. Nakatsu George P. McCabe Mary Ann Lila Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries Antioxidants blueberries polyphenols anthocyanins precision nutrition |
| title | Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries |
| title_full | Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries |
| title_fullStr | Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries |
| title_full_unstemmed | Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries |
| title_short | Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries |
| title_sort | crop host and gut microbiome variation influence precision nutrition an example of blueberries |
| topic | blueberries polyphenols anthocyanins precision nutrition |
| url | https://www.mdpi.com/2076-3921/12/5/1136 |
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