<i>Plinia trunciflora</i> Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats
The disruption of redox homeostasis and neuroinflammation are key mechanisms in the pathogenesis of brain hypoxia–ischemia (HI); medicinal plants have been studied as a therapeutic strategy, generally associated with the prevention of oxidative stress and inflammatory response. This study evaluates...
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MDPI AG
2022-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/2/395 |
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| author | Andrey Vinicios S. Carvalho Rafael T. Ribeiro Luz Elena Durán-Carabali Ana Paula R. Martini Eduarda Hoeper Eduardo F. Sanches Eduardo Luis Konrath Carla Dalmaz Moacir Wajner Carlos Alexandre Netto |
| author_facet | Andrey Vinicios S. Carvalho Rafael T. Ribeiro Luz Elena Durán-Carabali Ana Paula R. Martini Eduarda Hoeper Eduardo F. Sanches Eduardo Luis Konrath Carla Dalmaz Moacir Wajner Carlos Alexandre Netto |
| author_sort | Andrey Vinicios S. Carvalho |
| collection | DOAJ |
| description | The disruption of redox homeostasis and neuroinflammation are key mechanisms in the pathogenesis of brain hypoxia–ischemia (HI); medicinal plants have been studied as a therapeutic strategy, generally associated with the prevention of oxidative stress and inflammatory response. This study evaluates the neuroprotective role of the <i>Plinia trunciflora</i> fruit extract (PTE) in neonatal rats submitted to experimental HI. The HI insult provoked a marked increase in the lipoperoxidation levels and glutathione peroxidase (GPx) activity, accompanied by a decrease in the brain concentration of glutathione (GSH). Interestingly, PTE was able to prevent most of the HI-induced pro-oxidant effects. It was also observed that HI increased the levels of interleukin-1β in the hippocampus, and that PTE-treatment prevented this effect. Furthermore, PTE was able to prevent neuronal loss and astrocyte reactivity induced by HI, as demonstrated by NeuN and GFAP staining, respectively. PTE also attenuated the anxiety-like behavior and prevented the spatial memory impairment caused by HI. Finally, PTE prevented neural tissue loss in the brain hemisphere, the hippocampus, cerebral cortex, and the striatum ipsilateral to the HI. Taken together our results provide good evidence that the PTE extract has the potential to be investigated as an adjunctive therapy in the treatment of brain insult caused by neonatal hypoxia–ischemia. |
| first_indexed | 2024-03-10T00:46:33Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T00:46:33Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e3d5d0e34c96499698c017178bb851892023-11-23T14:58:47ZengMDPI AGNutrients2072-66432022-01-0114239510.3390/nu14020395<i>Plinia trunciflora</i> Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in RatsAndrey Vinicios S. Carvalho0Rafael T. Ribeiro1Luz Elena Durán-Carabali2Ana Paula R. Martini3Eduarda Hoeper4Eduardo F. Sanches5Eduardo Luis Konrath6Carla Dalmaz7Moacir Wajner8Carlos Alexandre Netto9Post-Graduation Program of Neuroscience, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90046-900, BrazilPost-Graduation Program of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, BrazilPost-Graduation Program of Physiology, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90050-170, BrazilPost-Graduation Program of Neuroscience, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90046-900, BrazilDepartment of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, BrazilPost-Graduation Program of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, BrazilDepartment of Pharmaceutical Sciences, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, BrazilPost-Graduation Program of Neuroscience, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90046-900, BrazilPost-Graduation Program of Biochemistry, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90460-060, BrazilPost-Graduation Program of Neuroscience, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90046-900, BrazilThe disruption of redox homeostasis and neuroinflammation are key mechanisms in the pathogenesis of brain hypoxia–ischemia (HI); medicinal plants have been studied as a therapeutic strategy, generally associated with the prevention of oxidative stress and inflammatory response. This study evaluates the neuroprotective role of the <i>Plinia trunciflora</i> fruit extract (PTE) in neonatal rats submitted to experimental HI. The HI insult provoked a marked increase in the lipoperoxidation levels and glutathione peroxidase (GPx) activity, accompanied by a decrease in the brain concentration of glutathione (GSH). Interestingly, PTE was able to prevent most of the HI-induced pro-oxidant effects. It was also observed that HI increased the levels of interleukin-1β in the hippocampus, and that PTE-treatment prevented this effect. Furthermore, PTE was able to prevent neuronal loss and astrocyte reactivity induced by HI, as demonstrated by NeuN and GFAP staining, respectively. PTE also attenuated the anxiety-like behavior and prevented the spatial memory impairment caused by HI. Finally, PTE prevented neural tissue loss in the brain hemisphere, the hippocampus, cerebral cortex, and the striatum ipsilateral to the HI. Taken together our results provide good evidence that the PTE extract has the potential to be investigated as an adjunctive therapy in the treatment of brain insult caused by neonatal hypoxia–ischemia.https://www.mdpi.com/2072-6643/14/2/395hypoxia–ischemia (HI)<i>Plinia trunciflora</i> extract (PTE)medicinal plantsantioxidantsspatial memoryneuroprotection |
| spellingShingle | Andrey Vinicios S. Carvalho Rafael T. Ribeiro Luz Elena Durán-Carabali Ana Paula R. Martini Eduarda Hoeper Eduardo F. Sanches Eduardo Luis Konrath Carla Dalmaz Moacir Wajner Carlos Alexandre Netto <i>Plinia trunciflora</i> Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats Nutrients hypoxia–ischemia (HI) <i>Plinia trunciflora</i> extract (PTE) medicinal plants antioxidants spatial memory neuroprotection |
| title | <i>Plinia trunciflora</i> Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats |
| title_full | <i>Plinia trunciflora</i> Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats |
| title_fullStr | <i>Plinia trunciflora</i> Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats |
| title_full_unstemmed | <i>Plinia trunciflora</i> Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats |
| title_short | <i>Plinia trunciflora</i> Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats |
| title_sort | i plinia trunciflora i extract administration prevents hi induced oxidative stress inflammatory response behavioral impairments and tissue damage in rats |
| topic | hypoxia–ischemia (HI) <i>Plinia trunciflora</i> extract (PTE) medicinal plants antioxidants spatial memory neuroprotection |
| url | https://www.mdpi.com/2072-6643/14/2/395 |
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