The influence of microbiota on the development and course of inflammatory diseases of periodontal tissues
An important feature of the functioning of the organs and tissues of the oral cavity is the fact that all processes that take place in it are carried out in the constant presence of various microorganisms that cause the development of pathological processes in the body or are associated with them. I...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Oral Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2023.1237448/full |
| _version_ | 1797752234165927936 |
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| author | Andrii Demkovych Dmytro Kalashnikov Petro Hasiuk Sergiy Zubchenko Anna Vorobets |
| author_facet | Andrii Demkovych Dmytro Kalashnikov Petro Hasiuk Sergiy Zubchenko Anna Vorobets |
| author_sort | Andrii Demkovych |
| collection | DOAJ |
| description | An important feature of the functioning of the organs and tissues of the oral cavity is the fact that all processes that take place in it are carried out in the constant presence of various microorganisms that cause the development of pathological processes in the body or are associated with them. In the pathogenesis of chronic generalized periodontitis, dental plaque penetrates the bottom of the gingival sulcus, penetrating under the epithelium into the stroma of the connective tissue, causing its inflammation. Bacteria produce a number of toxic substances that have a toxic effect on surrounding tissues. Most bacteria produce chain fatty acids that inhibit chemotaxis of leukocytes and phagocytes. Anaerobes and spirochetes secrete a number of substances (propionic acid and indole) that are extremely toxic to most tissues. Inflammation in the periodontal tissues is caused by the microbiota of the dental plaque biofilm. As periodontitis develops, an increase in the number of P. gingivalis, P. intermedia and T. forsythia was found in it, more than 100 times. Therefore, the given data prove that in the development and course of the inflammatory process in the periodontal tissues, complex dysbiotic and tissue-cellular interactions are involved, the dynamic balance of which depends on its outcome. |
| first_indexed | 2024-03-12T17:00:16Z |
| format | Article |
| id | doaj.art-e3d6876121bb4695b819084c9119dd88 |
| institution | Directory Open Access Journal |
| issn | 2673-4842 |
| language | English |
| last_indexed | 2024-03-12T17:00:16Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj.art-e3d6876121bb4695b819084c9119dd882023-08-07T17:27:00ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422023-08-01410.3389/froh.2023.12374481237448The influence of microbiota on the development and course of inflammatory diseases of periodontal tissuesAndrii Demkovych0Dmytro Kalashnikov1Petro Hasiuk2Sergiy Zubchenko3Anna Vorobets4Department of Orthopedic Dentistry, I. Horbachevsky Ternopil National Medical University, Ternopil, UkraineDepartment of Propaedeutics of Prosthetic Dentistry, Poltava State Medical University, Poltava, UkraineDepartment of Orthopedic Dentistry, I. Horbachevsky Ternopil National Medical University, Ternopil, UkraineDepartment of Propaedeutics of Prosthetic Dentistry, Poltava State Medical University, Poltava, UkraineDepartment of Orthopedic Dentistry, I. Horbachevsky Ternopil National Medical University, Ternopil, UkraineAn important feature of the functioning of the organs and tissues of the oral cavity is the fact that all processes that take place in it are carried out in the constant presence of various microorganisms that cause the development of pathological processes in the body or are associated with them. In the pathogenesis of chronic generalized periodontitis, dental plaque penetrates the bottom of the gingival sulcus, penetrating under the epithelium into the stroma of the connective tissue, causing its inflammation. Bacteria produce a number of toxic substances that have a toxic effect on surrounding tissues. Most bacteria produce chain fatty acids that inhibit chemotaxis of leukocytes and phagocytes. Anaerobes and spirochetes secrete a number of substances (propionic acid and indole) that are extremely toxic to most tissues. Inflammation in the periodontal tissues is caused by the microbiota of the dental plaque biofilm. As periodontitis develops, an increase in the number of P. gingivalis, P. intermedia and T. forsythia was found in it, more than 100 times. Therefore, the given data prove that in the development and course of the inflammatory process in the periodontal tissues, complex dysbiotic and tissue-cellular interactions are involved, the dynamic balance of which depends on its outcome.https://www.frontiersin.org/articles/10.3389/froh.2023.1237448/fullperiodontiumgeneralized periodontitismicrobiotainflammationmicroorganisms |
| spellingShingle | Andrii Demkovych Dmytro Kalashnikov Petro Hasiuk Sergiy Zubchenko Anna Vorobets The influence of microbiota on the development and course of inflammatory diseases of periodontal tissues Frontiers in Oral Health periodontium generalized periodontitis microbiota inflammation microorganisms |
| title | The influence of microbiota on the development and course of inflammatory diseases of periodontal tissues |
| title_full | The influence of microbiota on the development and course of inflammatory diseases of periodontal tissues |
| title_fullStr | The influence of microbiota on the development and course of inflammatory diseases of periodontal tissues |
| title_full_unstemmed | The influence of microbiota on the development and course of inflammatory diseases of periodontal tissues |
| title_short | The influence of microbiota on the development and course of inflammatory diseases of periodontal tissues |
| title_sort | influence of microbiota on the development and course of inflammatory diseases of periodontal tissues |
| topic | periodontium generalized periodontitis microbiota inflammation microorganisms |
| url | https://www.frontiersin.org/articles/10.3389/froh.2023.1237448/full |
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