Aspirin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing the ERK/MAPK pathway

Aspirin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing the ERK/MAPK pathway

This study aimed to investigate the therapeutic effects of aspirin (ASA) and its potential mechanisms of action in monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats. PAH was induced in a rat model by a single intraperitoneal (IP) injection of MCT. Saline was injected in a con...

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Bibliographic Details
Main Authors: Hua Gao, Yuqing Cheng, Liguo Zong, Linian Huang, Chenchen Qiao, Wei Li, Beilei Gong, Junfeng Hu, Haitao Liu, Xiaojing Wang, Chengling Zhao
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Clinical and Experimental Hypertension
Subjects:
aspirin
erk1/2
nonsteroidal anti-inflammatory drugs
pulmonary arterial hypertension
Online Access:http://dx.doi.org/10.1080/10641963.2016.1210620

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