Sensitivity of the African neuropsychology battery memory subtests and learning slopes in discriminating APOE 4 and amyloid pathology in adult individuals in the Democratic Republic of Congo
BackgroundThe current study examined the sensitivity of two memory subtests and their corresponding learning slope metrics derived from the African Neuropsychology Battery (ANB) to detect amyloid pathology and APOEε4 status in adults from Kinshasa, the Democratic Republic of the Congo.Methods85 part...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1320727/full |
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| author | Jean Ikanga Jean Ikanga Sarah D. Patrick Megan Schwinne Saranya Sundaram Patel Emmanuel Epenge Guy Gikelekele Nathan Tshengele Immaculee Kavugho Samuel Mampunza Kevin E. Yarasheski Charlotte E. Teunissen Anthony Stringer Allan Levey Julio C. Rojas Brandon Chan Argentina Lario Lago Joel H. Kramer Adam L. Boxer Andreas Jeromin Alvaro Alonso Robert J. Spencer |
| author_facet | Jean Ikanga Jean Ikanga Sarah D. Patrick Megan Schwinne Saranya Sundaram Patel Emmanuel Epenge Guy Gikelekele Nathan Tshengele Immaculee Kavugho Samuel Mampunza Kevin E. Yarasheski Charlotte E. Teunissen Anthony Stringer Allan Levey Julio C. Rojas Brandon Chan Argentina Lario Lago Joel H. Kramer Adam L. Boxer Andreas Jeromin Alvaro Alonso Robert J. Spencer |
| author_sort | Jean Ikanga |
| collection | DOAJ |
| description | BackgroundThe current study examined the sensitivity of two memory subtests and their corresponding learning slope metrics derived from the African Neuropsychology Battery (ANB) to detect amyloid pathology and APOEε4 status in adults from Kinshasa, the Democratic Republic of the Congo.Methods85 participants were classified for the presence of β-amyloid pathology and based on allelic presence of APOEε4 using Simoa. All participants were screened using CSID and AQ, underwent verbal and visuospatial memory testing from ANB, and provided blood samples for plasma Aβ42, Aβ40, and APOE proteotype. Pearson correlation, linear and logistic regression were conducted to compare amyloid pathology and APOEε4 status with derived learning scores, including initial learning, raw learning score, learning over trials, and learning ratio.ResultsOur sample included 35 amyloid positive and 44 amyloid negative individuals as well as 42 without and 39 with APOEε4. All ROC AUC ranges for the prediction of amyloid pathology based on learning scores were low, ranging between 0.56–0.70 (95% CI ranging from 0.44–0.82). The sensitivity of all the scores ranged between 54.3–88.6, with some learning metrics demonstrating good sensitivity. Regarding APOEε4 prediction, all AUC values ranged between 0.60–0.69, with all sensitivity measures ranging between 53.8–89.7. There were minimal differences in the AUC values across learning slope metrics, largely due to the lack of ceiling effects in this sample.DiscussionThis study demonstrates that some ANB memory subtests and learning slope metrics can discriminate those that are normal from those with amyloid pathology and those with and without APOEε4, consistent with findings reported in Western populations. |
| first_indexed | 2024-04-24T18:46:50Z |
| format | Article |
| id | doaj.art-e3d94e435dd849f58ef490f65ed9a352 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-24T18:46:50Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-e3d94e435dd849f58ef490f65ed9a3522024-03-27T05:12:25ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-03-011510.3389/fneur.2024.13207271320727Sensitivity of the African neuropsychology battery memory subtests and learning slopes in discriminating APOE 4 and amyloid pathology in adult individuals in the Democratic Republic of CongoJean Ikanga0Jean Ikanga1Sarah D. Patrick2Megan Schwinne3Saranya Sundaram Patel4Emmanuel Epenge5Guy Gikelekele6Nathan Tshengele7Immaculee Kavugho8Samuel Mampunza9Kevin E. Yarasheski10Charlotte E. Teunissen11Anthony Stringer12Allan Levey13Julio C. Rojas14Brandon Chan15Argentina Lario Lago16Joel H. Kramer17Adam L. Boxer18Andreas Jeromin19Alvaro Alonso20Robert J. Spencer21Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA, United StatesDepartment of Psychiatry, School of Medicine, University of Kinshasa and Catholic University of Congo, Kinshasa, Democratic Republic of CongoVeteran Affairs Ann Arbor Healthcare System, Ann Arbor, MI, United StatesDepartment of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, United StatesDepartment of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA, United StatesDepartment of Neurology, University of Kinshasa, Kinshasa, Democratic Republic of CongoDepartment of Psychiatry, School of Medicine, University of Kinshasa and Catholic University of Congo, Kinshasa, Democratic Republic of CongoDepartment of Psychiatry, School of Medicine, University of Kinshasa and Catholic University of Congo, Kinshasa, Democratic Republic of CongoMemory Clinic of Kinshasa, Kinshasa, Democratic Republic of CongoDepartment of Psychiatry, School of Medicine, University of Kinshasa and Catholic University of Congo, Kinshasa, Democratic Republic of CongoC2N Diagnostics, St. Louis, MO, United StatesNeurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Neurodegeneration, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, NetherlandsDepartment of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA, United StatesDepartment of Neurology, School of Medicine, Emory University, Atlanta, GA, United States0Department of Neurology, University of San Francisco, Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, United States0Department of Neurology, University of San Francisco, Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, United States0Department of Neurology, University of San Francisco, Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, United States0Department of Neurology, University of San Francisco, Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, United States0Department of Neurology, University of San Francisco, Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, United States1ALZpath, Inc., Carlsbad, CA, United States2Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, United StatesVeteran Affairs Ann Arbor Healthcare System, Ann Arbor, MI, United StatesBackgroundThe current study examined the sensitivity of two memory subtests and their corresponding learning slope metrics derived from the African Neuropsychology Battery (ANB) to detect amyloid pathology and APOEε4 status in adults from Kinshasa, the Democratic Republic of the Congo.Methods85 participants were classified for the presence of β-amyloid pathology and based on allelic presence of APOEε4 using Simoa. All participants were screened using CSID and AQ, underwent verbal and visuospatial memory testing from ANB, and provided blood samples for plasma Aβ42, Aβ40, and APOE proteotype. Pearson correlation, linear and logistic regression were conducted to compare amyloid pathology and APOEε4 status with derived learning scores, including initial learning, raw learning score, learning over trials, and learning ratio.ResultsOur sample included 35 amyloid positive and 44 amyloid negative individuals as well as 42 without and 39 with APOEε4. All ROC AUC ranges for the prediction of amyloid pathology based on learning scores were low, ranging between 0.56–0.70 (95% CI ranging from 0.44–0.82). The sensitivity of all the scores ranged between 54.3–88.6, with some learning metrics demonstrating good sensitivity. Regarding APOEε4 prediction, all AUC values ranged between 0.60–0.69, with all sensitivity measures ranging between 53.8–89.7. There were minimal differences in the AUC values across learning slope metrics, largely due to the lack of ceiling effects in this sample.DiscussionThis study demonstrates that some ANB memory subtests and learning slope metrics can discriminate those that are normal from those with amyloid pathology and those with and without APOEε4, consistent with findings reported in Western populations.https://www.frontiersin.org/articles/10.3389/fneur.2024.1320727/fullmemorylearning slopeAPOEamyloidDemocratic Republic of Congo |
| spellingShingle | Jean Ikanga Jean Ikanga Sarah D. Patrick Megan Schwinne Saranya Sundaram Patel Emmanuel Epenge Guy Gikelekele Nathan Tshengele Immaculee Kavugho Samuel Mampunza Kevin E. Yarasheski Charlotte E. Teunissen Anthony Stringer Allan Levey Julio C. Rojas Brandon Chan Argentina Lario Lago Joel H. Kramer Adam L. Boxer Andreas Jeromin Alvaro Alonso Robert J. Spencer Sensitivity of the African neuropsychology battery memory subtests and learning slopes in discriminating APOE 4 and amyloid pathology in adult individuals in the Democratic Republic of Congo Frontiers in Neurology memory learning slope APOE amyloid Democratic Republic of Congo |
| title | Sensitivity of the African neuropsychology battery memory subtests and learning slopes in discriminating APOE 4 and amyloid pathology in adult individuals in the Democratic Republic of Congo |
| title_full | Sensitivity of the African neuropsychology battery memory subtests and learning slopes in discriminating APOE 4 and amyloid pathology in adult individuals in the Democratic Republic of Congo |
| title_fullStr | Sensitivity of the African neuropsychology battery memory subtests and learning slopes in discriminating APOE 4 and amyloid pathology in adult individuals in the Democratic Republic of Congo |
| title_full_unstemmed | Sensitivity of the African neuropsychology battery memory subtests and learning slopes in discriminating APOE 4 and amyloid pathology in adult individuals in the Democratic Republic of Congo |
| title_short | Sensitivity of the African neuropsychology battery memory subtests and learning slopes in discriminating APOE 4 and amyloid pathology in adult individuals in the Democratic Republic of Congo |
| title_sort | sensitivity of the african neuropsychology battery memory subtests and learning slopes in discriminating apoe 4 and amyloid pathology in adult individuals in the democratic republic of congo |
| topic | memory learning slope APOE amyloid Democratic Republic of Congo |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1320727/full |
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