TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury

TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury

Lung disease causes significant morbidity and mortality, and is exacerbated by environmental injury, for example through lipopolysaccharide (LPS) or ozone (O3). Toll-like receptors (TLRs) orchestrate immune responses to injury by recognizing pathogen- or danger-associated molecular patterns. TLR4, t...

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Bibliographic Details
Main Authors: Salik Hussain, Collin G Johnson, Joseph Sciurba, Xianglin Meng, Vandy P Stober, Caini Liu, Jaime M Cyphert-Daly, Katarzyna Bulek, Wen Qian, Alma Solis, Yosuke Sakamachi, Carol S Trempus, Jim J Aloor, Kym M Gowdy, W Michael Foster, John W Hollingsworth, Robert M Tighe, Xiaoxia Li, Michael B Fessler, Stavros Garantziotis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
inflammation
innate immune receptors
TLR4
TLR5
Online Access:https://elifesciences.org/articles/50458

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