SHMT2 Promotes Gastric Cancer Development through Regulation of HIF1α/VEGF/STAT3 Signaling

SHMT2 Promotes Gastric Cancer Development through Regulation of HIF1α/VEGF/STAT3 Signaling

The metabolic enzymes involved in one-carbon metabolism are closely associated with tumor progression and could be potential targets for cancer therapy. Recent studies showed that serine hydroxymethyltransferase 2 (SHMT2), a crucial enzyme in the one-carbon metabolic pathway, plays a key role in tum...

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Bibliographic Details
Main Authors: Weida Wang, Mingjin Wang, Tingting Du, Zhenyan Hou, Shen You, Sen Zhang, Ming Ji, Nina Xue, Xiaoguang Chen
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
gastric cancer
SHMT2
HIF1α
redox balance
progression
Online Access:https://www.mdpi.com/1422-0067/24/8/7150

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