Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats
In the search for new potential antihyperlipidemic agents, the present study focuses on the synthesis of novel N-(benzoylphenyl)-5-substituted-1H-indole-2-carboxamides (compounds 8-12, 15, 16, 18) and investigating their antihyperlipidemic activity using Triton WR-1339-induced hyperlipidemic rats as...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-09-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/10/8292/ |
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| author | Suhair Hikmat Ghassan Abu Sheikha Yusuf Al-Hiari Tariq Al-Qirim Waseem El-Huneidi Ghassan Shattat |
| author_facet | Suhair Hikmat Ghassan Abu Sheikha Yusuf Al-Hiari Tariq Al-Qirim Waseem El-Huneidi Ghassan Shattat |
| author_sort | Suhair Hikmat |
| collection | DOAJ |
| description | In the search for new potential antihyperlipidemic agents, the present study focuses on the synthesis of novel N-(benzoylphenyl)-5-substituted-1H-indole-2-carboxamides (compounds 8-12, 15, 16, 18) and investigating their antihyperlipidemic activity using Triton WR-1339-induced hyperlipidemic rats as an experimental model. Hyperlipidemia was developed by intraperitoneal injection of Triton WR-1339 (250 mg/kg body weight). The tested animals were divided into normal control (NCG), hyperlipidemic (HG), compound 8, 9, 15, 16, 18- and bezafibrate treated groups. At a dose of 15 mg/kg body weight, compounds 9, 16, 18 and bezafibrate (100 mg/kg) significantly (p < 0.0001) reduced elevated plasma triglycerides levels after 12 h compared to the hyperlipidemic control group. However, only the group treated with compounds 9, 16 and 18 showed an obviously significant (p < 0.001) reduction in plasma total cholesterol levels after 12 h compared to the hyperlipidemic control group. Moreover, high density lipoprotein-cholesterol levels were significantly (p < 0.0001) increased in all treated groups after 12 h compared to the hyperlipidemic control group, except for compounds 8 and 15 which revealed inactive. It is therefore reasonable to assume that compounds 9, 16 and 18 may have potential in the treatment of hyperlipidemia. |
| first_indexed | 2024-12-19T17:12:40Z |
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| id | doaj.art-e3dbafc42a014a84b4e06fe56189c519 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-19T17:12:40Z |
| publishDate | 2011-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e3dbafc42a014a84b4e06fe56189c5192022-12-21T20:12:58ZengMDPI AGMolecules1420-30492011-09-0116108292830410.3390/molecules16108292Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic RatsSuhair HikmatGhassan Abu SheikhaYusuf Al-HiariTariq Al-QirimWaseem El-HuneidiGhassan ShattatIn the search for new potential antihyperlipidemic agents, the present study focuses on the synthesis of novel N-(benzoylphenyl)-5-substituted-1H-indole-2-carboxamides (compounds 8-12, 15, 16, 18) and investigating their antihyperlipidemic activity using Triton WR-1339-induced hyperlipidemic rats as an experimental model. Hyperlipidemia was developed by intraperitoneal injection of Triton WR-1339 (250 mg/kg body weight). The tested animals were divided into normal control (NCG), hyperlipidemic (HG), compound 8, 9, 15, 16, 18- and bezafibrate treated groups. At a dose of 15 mg/kg body weight, compounds 9, 16, 18 and bezafibrate (100 mg/kg) significantly (p < 0.0001) reduced elevated plasma triglycerides levels after 12 h compared to the hyperlipidemic control group. However, only the group treated with compounds 9, 16 and 18 showed an obviously significant (p < 0.001) reduction in plasma total cholesterol levels after 12 h compared to the hyperlipidemic control group. Moreover, high density lipoprotein-cholesterol levels were significantly (p < 0.0001) increased in all treated groups after 12 h compared to the hyperlipidemic control group, except for compounds 8 and 15 which revealed inactive. It is therefore reasonable to assume that compounds 9, 16 and 18 may have potential in the treatment of hyperlipidemia.http://www.mdpi.com/1420-3049/16/10/8292/Triton WR-1339-induced hyperlipidemic ratsN-(benzoylphenyl)-5-methoxy-1H-indole-2-carboxamideN-(Benzoylphenyl)-5-chloro-1H-indole-2-carboxamidehypo-lipidemic activity |
| spellingShingle | Suhair Hikmat Ghassan Abu Sheikha Yusuf Al-Hiari Tariq Al-Qirim Waseem El-Huneidi Ghassan Shattat Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats Molecules Triton WR-1339-induced hyperlipidemic rats N-(benzoylphenyl)-5-methoxy-1H-indole-2-carboxamide N-(Benzoylphenyl)-5-chloro-1H-indole-2-carboxamide hypo-lipidemic activity |
| title | Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats |
| title_full | Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats |
| title_fullStr | Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats |
| title_full_unstemmed | Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats |
| title_short | Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats |
| title_sort | antihyperlipidemic properties of novel n benzoylphenyl 5 substituted 1h indole 2 carboxamides in triton wr 1339 induced hyperlipidemic rats |
| topic | Triton WR-1339-induced hyperlipidemic rats N-(benzoylphenyl)-5-methoxy-1H-indole-2-carboxamide N-(Benzoylphenyl)-5-chloro-1H-indole-2-carboxamide hypo-lipidemic activity |
| url | http://www.mdpi.com/1420-3049/16/10/8292/ |
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