Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation
Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated ion channels and function as such in the central and peripheral nervous systems. Recently, however, non-ionic signaling mechanisms via nAChRs have been demonstrated in immune cells. Furthermore, the signaling p...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661823000713 |
| _version_ | 1797448153911263232 |
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| author | Arik J. Hone J. Michael McIntosh |
| author_facet | Arik J. Hone J. Michael McIntosh |
| author_sort | Arik J. Hone |
| collection | DOAJ |
| description | Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated ion channels and function as such in the central and peripheral nervous systems. Recently, however, non-ionic signaling mechanisms via nAChRs have been demonstrated in immune cells. Furthermore, the signaling pathways where nAChRs are expressed can be activated by endogenous ligands other than the canonical agonists acetylcholine and choline. In this review, we discuss the involvement of a subset of nAChRs containing α7, α9, and/or α10 subunits in the modulation of pain and inflammation via the cholinergic anti-inflammatory pathway. Additionally, we review the most recent advances in the development of novel ligands and their potential as therapeutics. |
| first_indexed | 2024-03-09T14:06:22Z |
| format | Article |
| id | doaj.art-e3dca2c0dcc244888c3c7ab7f37cf7d2 |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-09T14:06:22Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-e3dca2c0dcc244888c3c7ab7f37cf7d22023-11-30T05:05:55ZengElsevierPharmacological Research1096-11862023-04-01190106715Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammationArik J. Hone0J. Michael McIntosh1School of Biological Sciences University of Utah, Salt Lake City, UT, USA; MIRECC, George E. Whalen Veterans Affairs Medical Center, Salt Lake City, UT, USA; Corresponding authors at: School of Biological Sciences University of Utah, Salt Lake City, UT, USA.School of Biological Sciences University of Utah, Salt Lake City, UT, USA; Department of Psychiatry, University of Utah, Salt Lake City, UT, USA; George E. Whalen Veterans Affairs Medical Center, Salt Lake City, UT, USA; Corresponding authors at: School of Biological Sciences University of Utah, Salt Lake City, UT, USA.Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated ion channels and function as such in the central and peripheral nervous systems. Recently, however, non-ionic signaling mechanisms via nAChRs have been demonstrated in immune cells. Furthermore, the signaling pathways where nAChRs are expressed can be activated by endogenous ligands other than the canonical agonists acetylcholine and choline. In this review, we discuss the involvement of a subset of nAChRs containing α7, α9, and/or α10 subunits in the modulation of pain and inflammation via the cholinergic anti-inflammatory pathway. Additionally, we review the most recent advances in the development of novel ligands and their potential as therapeutics.http://www.sciencedirect.com/science/article/pii/S1043661823000713Nicotinic acetylcholine receptor subunits α7, α9, and α10Neuropathic painChronic painInflammatory painChemotherapy-induced neuropathic painα-conotoxin RgIA |
| spellingShingle | Arik J. Hone J. Michael McIntosh Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation Pharmacological Research Nicotinic acetylcholine receptor subunits α7, α9, and α10 Neuropathic pain Chronic pain Inflammatory pain Chemotherapy-induced neuropathic pain α-conotoxin RgIA |
| title | Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation |
| title_full | Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation |
| title_fullStr | Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation |
| title_full_unstemmed | Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation |
| title_short | Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation |
| title_sort | nicotinic acetylcholine receptors therapeutic targets for novel ligands to treat pain and inflammation |
| topic | Nicotinic acetylcholine receptor subunits α7, α9, and α10 Neuropathic pain Chronic pain Inflammatory pain Chemotherapy-induced neuropathic pain α-conotoxin RgIA |
| url | http://www.sciencedirect.com/science/article/pii/S1043661823000713 |
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