Interaction Between Argonaute2 and RNA Molecules: AGO2 Molecular Structure and Different Regions in Nucleotide Chain
Argonaute2 (AGO2) is an important protein connecting the construction of RNA-induced silencing complex (RISC) and micro-RNA (miRNA) biogenesis. This paper explores the mechanism during the function through previous studies which reveal the crystal structure and affinity comparisons. It is concluded...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2023-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2023/04/bioconf_icbb2023_01001.pdf |
| _version_ | 1797829450674470912 |
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| author | Chen Chen |
| author_facet | Chen Chen |
| author_sort | Chen Chen |
| collection | DOAJ |
| description | Argonaute2 (AGO2) is an important protein connecting the construction of RNA-induced silencing complex (RISC) and micro-RNA (miRNA) biogenesis. This paper explores the mechanism during the function through previous studies which reveal the crystal structure and affinity comparisons. It is concluded that the AGO2 have compartmentalized domains for certain functions, which have both individual and cooperative role in the entire process. The characters of AGO2 and miRNA suggest a model of regiondifferent nucleotide chains in miRNA, which means its epigenetic information is based on base sequence and its special information. According to these findings, further studies are advised to monitor the reactions in a dynamical method, which would be a new potential entry point for clinical utilization. |
| first_indexed | 2024-04-09T13:20:28Z |
| format | Article |
| id | doaj.art-e3dde5f61a88451d8edeab10ef9a8713 |
| institution | Directory Open Access Journal |
| issn | 2117-4458 |
| language | English |
| last_indexed | 2024-04-09T13:20:28Z |
| publishDate | 2023-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj.art-e3dde5f61a88451d8edeab10ef9a87132023-05-11T09:08:11ZengEDP SciencesBIO Web of Conferences2117-44582023-01-01590100110.1051/bioconf/20235901001bioconf_icbb2023_01001Interaction Between Argonaute2 and RNA Molecules: AGO2 Molecular Structure and Different Regions in Nucleotide ChainChen Chen0UNIVERSITY NOTTINGHAM MALAYSIAArgonaute2 (AGO2) is an important protein connecting the construction of RNA-induced silencing complex (RISC) and micro-RNA (miRNA) biogenesis. This paper explores the mechanism during the function through previous studies which reveal the crystal structure and affinity comparisons. It is concluded that the AGO2 have compartmentalized domains for certain functions, which have both individual and cooperative role in the entire process. The characters of AGO2 and miRNA suggest a model of regiondifferent nucleotide chains in miRNA, which means its epigenetic information is based on base sequence and its special information. According to these findings, further studies are advised to monitor the reactions in a dynamical method, which would be a new potential entry point for clinical utilization.https://www.bio-conferences.org/articles/bioconf/pdf/2023/04/bioconf_icbb2023_01001.pdf |
| spellingShingle | Chen Chen Interaction Between Argonaute2 and RNA Molecules: AGO2 Molecular Structure and Different Regions in Nucleotide Chain BIO Web of Conferences |
| title | Interaction Between Argonaute2 and RNA Molecules: AGO2 Molecular Structure and Different Regions in Nucleotide Chain |
| title_full | Interaction Between Argonaute2 and RNA Molecules: AGO2 Molecular Structure and Different Regions in Nucleotide Chain |
| title_fullStr | Interaction Between Argonaute2 and RNA Molecules: AGO2 Molecular Structure and Different Regions in Nucleotide Chain |
| title_full_unstemmed | Interaction Between Argonaute2 and RNA Molecules: AGO2 Molecular Structure and Different Regions in Nucleotide Chain |
| title_short | Interaction Between Argonaute2 and RNA Molecules: AGO2 Molecular Structure and Different Regions in Nucleotide Chain |
| title_sort | interaction between argonaute2 and rna molecules ago2 molecular structure and different regions in nucleotide chain |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2023/04/bioconf_icbb2023_01001.pdf |
| work_keys_str_mv | AT chenchen interactionbetweenargonaute2andrnamoleculesago2molecularstructureanddifferentregionsinnucleotidechain |