Novel Therapeutic Strategies Targeting Molecular Pathways of Cystogenesis in Autosomal Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease that results from mutations in PKD1 or PKD2. The disease is characterized by the progressive development of fluid-filled cysts derived from renal tubular epithelial cells that destroy the architecture of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Codon Publications
2017-03-01
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| Series: | Journal of Renal and Hepatic Disorders |
| Subjects: | |
| Online Access: | https://jrenhep.com/index.php/jrenhep/article/view/10 |
| _version_ | 1818059035389198336 |
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| author | Maurizio Salvadori Aris Tsalouchos |
| author_facet | Maurizio Salvadori Aris Tsalouchos |
| author_sort | Maurizio Salvadori |
| collection | DOAJ |
| description | Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease that results from mutations in PKD1 or PKD2. The disease is characterized by the progressive development of fluid-filled cysts derived from renal tubular epithelial cells that destroy the architecture of the renal parenchyma and lead to kidney failure. Until recently, the causes and the molecular pathways that lead to cystogenesis remained obscure. In the last decade, enormous progress has been made in understanding the pathogenesis of ADPKD and the development of new therapies. The purpose of this review is to update on the promising therapies that are being developed and tested based on knowledge of recent advances in molecular and cellular targets involved in cystogenesis. |
| first_indexed | 2024-12-10T13:10:07Z |
| format | Article |
| id | doaj.art-e3de624b0ab4435ca79eae2a527e6511 |
| institution | Directory Open Access Journal |
| issn | 2207-3744 |
| language | English |
| last_indexed | 2024-12-10T13:10:07Z |
| publishDate | 2017-03-01 |
| publisher | Codon Publications |
| record_format | Article |
| series | Journal of Renal and Hepatic Disorders |
| spelling | doaj.art-e3de624b0ab4435ca79eae2a527e65112022-12-22T01:47:43ZengCodon PublicationsJournal of Renal and Hepatic Disorders2207-37442017-03-011110.15586/jrenhep.2017.107Novel Therapeutic Strategies Targeting Molecular Pathways of Cystogenesis in Autosomal Polycystic Kidney DiseaseMaurizio Salvadori0Aris Tsalouchos1Careggi University Hospital, Viale Pieraccini, 18, 50139, Florence, ItalyDivision of Nephrology, Azienda Ospedaliera Careggi, Largo Alessandro Brambilla, 3, 50134 ,Florence, ItalyAutosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease that results from mutations in PKD1 or PKD2. The disease is characterized by the progressive development of fluid-filled cysts derived from renal tubular epithelial cells that destroy the architecture of the renal parenchyma and lead to kidney failure. Until recently, the causes and the molecular pathways that lead to cystogenesis remained obscure. In the last decade, enormous progress has been made in understanding the pathogenesis of ADPKD and the development of new therapies. The purpose of this review is to update on the promising therapies that are being developed and tested based on knowledge of recent advances in molecular and cellular targets involved in cystogenesis.https://jrenhep.com/index.php/jrenhep/article/view/10adult autosomal polycystic kidney diseasecystogenesismTOR signallingsomatostatin analoguesvasopressin 2 receptor |
| spellingShingle | Maurizio Salvadori Aris Tsalouchos Novel Therapeutic Strategies Targeting Molecular Pathways of Cystogenesis in Autosomal Polycystic Kidney Disease Journal of Renal and Hepatic Disorders adult autosomal polycystic kidney disease cystogenesis mTOR signalling somatostatin analogues vasopressin 2 receptor |
| title | Novel Therapeutic Strategies Targeting Molecular Pathways of Cystogenesis in Autosomal Polycystic Kidney Disease |
| title_full | Novel Therapeutic Strategies Targeting Molecular Pathways of Cystogenesis in Autosomal Polycystic Kidney Disease |
| title_fullStr | Novel Therapeutic Strategies Targeting Molecular Pathways of Cystogenesis in Autosomal Polycystic Kidney Disease |
| title_full_unstemmed | Novel Therapeutic Strategies Targeting Molecular Pathways of Cystogenesis in Autosomal Polycystic Kidney Disease |
| title_short | Novel Therapeutic Strategies Targeting Molecular Pathways of Cystogenesis in Autosomal Polycystic Kidney Disease |
| title_sort | novel therapeutic strategies targeting molecular pathways of cystogenesis in autosomal polycystic kidney disease |
| topic | adult autosomal polycystic kidney disease cystogenesis mTOR signalling somatostatin analogues vasopressin 2 receptor |
| url | https://jrenhep.com/index.php/jrenhep/article/view/10 |
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