Phytochemical Characterization and Antimicrobial Activity of Several <i>Allium</i> Extracts
Microbial infections affect both the human population and animals. The appearance of more and more microbial strains resistant to classical treatments led to the need to develop new treatments. <i>Allium</i> plants are known for their antimicrobial properties due to their high content of...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/10/3980 |
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| author | Ioana Andreea Barbu Alexandra Ciorîță Rahela Carpa Augustin Catalin Moț Anca Butiuc-Keul Marcel Pârvu |
| author_facet | Ioana Andreea Barbu Alexandra Ciorîță Rahela Carpa Augustin Catalin Moț Anca Butiuc-Keul Marcel Pârvu |
| author_sort | Ioana Andreea Barbu |
| collection | DOAJ |
| description | Microbial infections affect both the human population and animals. The appearance of more and more microbial strains resistant to classical treatments led to the need to develop new treatments. <i>Allium</i> plants are known for their antimicrobial properties due to their high content of thiosulfinates, especially allicin, polyphenols or flavonoids. The hydroalcoholic extracts of six <i>Allium</i> species obtained by cold percolation were analyzed regarding their phytochemical compounds and antimicrobial activity. Among the six extracts, <i>Allium sativum</i> L. and <i>Allium ursinum</i> L. have similar contents of thiosulfinates (approx. 300 μg allicin equivalents/g), and the contents of polyphenols and flavonoids were different between the tested species. The HPLC-DAD method was used to detail the phytochemical composition of species rich in thiosulfinates. <i>A. sativum</i> is richer in allicin (280 μg/g) than <i>A. ursinum</i> (130 μg/g). The antimicrobial activity of <i>A. sativum</i> and <i>A. ursinum</i> extracts against <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, <i>Candida albicans</i> and <i>Candida parapsilosis</i> can be correlated with the presence of large amounts of thiosulfinates. Both extracts have shown results against <i>Candida</i> species (inhibition zones of 20–35 mm) and against Gram-positive bacteria, <i>Staphylococcus aureus</i> (inhibition zones of 15–25 mm). These results demonstrate the antimicrobial effect of the extracts and suggest their use as an adjuvant treatment for microbial infections. |
| first_indexed | 2024-03-11T03:27:50Z |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T03:27:50Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e3e097e38d844f4696e078d1f78258792023-11-18T02:37:33ZengMDPI AGMolecules1420-30492023-05-012810398010.3390/molecules28103980Phytochemical Characterization and Antimicrobial Activity of Several <i>Allium</i> ExtractsIoana Andreea Barbu0Alexandra Ciorîță1Rahela Carpa2Augustin Catalin Moț3Anca Butiuc-Keul4Marcel Pârvu5Faculty of Biology and Geology, Babeș-Bolyai University, 1 M. Koganiceanu Str., 400084 Cluj-Napoca, RomaniaFaculty of Biology and Geology, Babeș-Bolyai University, 1 M. Koganiceanu Str., 400084 Cluj-Napoca, RomaniaFaculty of Biology and Geology, Babeș-Bolyai University, 1 M. Koganiceanu Str., 400084 Cluj-Napoca, RomaniaFaculty of Chemistry and Chemical Engineering, Babes-Bolyai University, 11 Arany Janos Str., 400028 Cluj-Napoca, RomaniaFaculty of Biology and Geology, Babeș-Bolyai University, 1 M. Koganiceanu Str., 400084 Cluj-Napoca, RomaniaFaculty of Biology and Geology, Babeș-Bolyai University, 1 M. Koganiceanu Str., 400084 Cluj-Napoca, RomaniaMicrobial infections affect both the human population and animals. The appearance of more and more microbial strains resistant to classical treatments led to the need to develop new treatments. <i>Allium</i> plants are known for their antimicrobial properties due to their high content of thiosulfinates, especially allicin, polyphenols or flavonoids. The hydroalcoholic extracts of six <i>Allium</i> species obtained by cold percolation were analyzed regarding their phytochemical compounds and antimicrobial activity. Among the six extracts, <i>Allium sativum</i> L. and <i>Allium ursinum</i> L. have similar contents of thiosulfinates (approx. 300 μg allicin equivalents/g), and the contents of polyphenols and flavonoids were different between the tested species. The HPLC-DAD method was used to detail the phytochemical composition of species rich in thiosulfinates. <i>A. sativum</i> is richer in allicin (280 μg/g) than <i>A. ursinum</i> (130 μg/g). The antimicrobial activity of <i>A. sativum</i> and <i>A. ursinum</i> extracts against <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, <i>Candida albicans</i> and <i>Candida parapsilosis</i> can be correlated with the presence of large amounts of thiosulfinates. Both extracts have shown results against <i>Candida</i> species (inhibition zones of 20–35 mm) and against Gram-positive bacteria, <i>Staphylococcus aureus</i> (inhibition zones of 15–25 mm). These results demonstrate the antimicrobial effect of the extracts and suggest their use as an adjuvant treatment for microbial infections.https://www.mdpi.com/1420-3049/28/10/3980<i>Allium</i>antimicrobial activityallicinphytochemical analysis |
| spellingShingle | Ioana Andreea Barbu Alexandra Ciorîță Rahela Carpa Augustin Catalin Moț Anca Butiuc-Keul Marcel Pârvu Phytochemical Characterization and Antimicrobial Activity of Several <i>Allium</i> Extracts Molecules <i>Allium</i> antimicrobial activity allicin phytochemical analysis |
| title | Phytochemical Characterization and Antimicrobial Activity of Several <i>Allium</i> Extracts |
| title_full | Phytochemical Characterization and Antimicrobial Activity of Several <i>Allium</i> Extracts |
| title_fullStr | Phytochemical Characterization and Antimicrobial Activity of Several <i>Allium</i> Extracts |
| title_full_unstemmed | Phytochemical Characterization and Antimicrobial Activity of Several <i>Allium</i> Extracts |
| title_short | Phytochemical Characterization and Antimicrobial Activity of Several <i>Allium</i> Extracts |
| title_sort | phytochemical characterization and antimicrobial activity of several i allium i extracts |
| topic | <i>Allium</i> antimicrobial activity allicin phytochemical analysis |
| url | https://www.mdpi.com/1420-3049/28/10/3980 |
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