Biomarkers of delirium risk in older adults: a systematic review and meta-analysis
Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the pathophysiology of this syndrome and provide guidance for future studies. Two...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1174644/full |
| _version_ | 1797829039245754368 |
|---|---|
| author | Lucía Lozano-Vicario Antonio García-Hermoso Bernardo Abel Cedeno-Veloz Joaquín Fernández-Irigoyen Enrique Santamaría Román Romero-Ortuno Fabricio Zambom-Ferraresi Fabricio Zambom-Ferraresi Mikel L. Sáez de Asteasu Ángel Javier Muñoz-Vázquez Mikel Izquierdo Mikel Izquierdo Nicolás Martínez-Velilla Nicolás Martínez-Velilla Nicolás Martínez-Velilla |
| author_facet | Lucía Lozano-Vicario Antonio García-Hermoso Bernardo Abel Cedeno-Veloz Joaquín Fernández-Irigoyen Enrique Santamaría Román Romero-Ortuno Fabricio Zambom-Ferraresi Fabricio Zambom-Ferraresi Mikel L. Sáez de Asteasu Ángel Javier Muñoz-Vázquez Mikel Izquierdo Mikel Izquierdo Nicolás Martínez-Velilla Nicolás Martínez-Velilla Nicolás Martínez-Velilla |
| author_sort | Lucía Lozano-Vicario |
| collection | DOAJ |
| description | Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the pathophysiology of this syndrome and provide guidance for future studies. Two authors independently and systematically searched MEDLINE, Embase, Cochrane Library, Web of Science and Scopus databases up to August 2021. A total of 32 studies were included. Only 6 studies were eligible for the meta-analysis, pooled results showed a significant increase in some serum biomarkers (C-reactive protein [CRP], tumour necrosis factor alpha [TNF-α] and interleukin-6 [IL-6]) among patients with delirium (odds ratio = 1.88, 95% CI 1.01 to 1.637; I2 = 76.75%). Although current evidence does not favour the use of any particular biomarker, serum CRP, TNF-α, and IL-6 were the most consistent biomarkers of delirium in older patients. |
| first_indexed | 2024-04-09T13:14:01Z |
| format | Article |
| id | doaj.art-e3e1c8720ad4499ca8e4844e1c155c56 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-09T13:14:01Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-e3e1c8720ad4499ca8e4844e1c155c562023-05-12T05:31:57ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-05-011510.3389/fnagi.2023.11746441174644Biomarkers of delirium risk in older adults: a systematic review and meta-analysisLucía Lozano-Vicario0Antonio García-Hermoso1Bernardo Abel Cedeno-Veloz2Joaquín Fernández-Irigoyen3Enrique Santamaría4Román Romero-Ortuno5Fabricio Zambom-Ferraresi6Fabricio Zambom-Ferraresi7Mikel L. Sáez de Asteasu8Ángel Javier Muñoz-Vázquez9Mikel Izquierdo10Mikel Izquierdo11Nicolás Martínez-Velilla12Nicolás Martínez-Velilla13Nicolás Martínez-Velilla14Geriatric Unit, Hospital Universitario de Navarra (HUN), Pamplona, SpainNavarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, SpainGeriatric Unit, Hospital Universitario de Navarra (HUN), Pamplona, SpainProteomics Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IDISNA), Pamplona, SpainProteomics Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IDISNA), Pamplona, SpainGlobal Brain Health Institute, Trinity College Dublin, Dublin, IrelandNavarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, SpainCIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, SpainNavarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, SpainOrthopaedic Surgery and Traumatology Department, Clínica Universidad de Navarra, Pamplona, SpainNavarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, SpainCIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, SpainGeriatric Unit, Hospital Universitario de Navarra (HUN), Pamplona, SpainNavarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, SpainCIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, SpainDelirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the pathophysiology of this syndrome and provide guidance for future studies. Two authors independently and systematically searched MEDLINE, Embase, Cochrane Library, Web of Science and Scopus databases up to August 2021. A total of 32 studies were included. Only 6 studies were eligible for the meta-analysis, pooled results showed a significant increase in some serum biomarkers (C-reactive protein [CRP], tumour necrosis factor alpha [TNF-α] and interleukin-6 [IL-6]) among patients with delirium (odds ratio = 1.88, 95% CI 1.01 to 1.637; I2 = 76.75%). Although current evidence does not favour the use of any particular biomarker, serum CRP, TNF-α, and IL-6 were the most consistent biomarkers of delirium in older patients.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1174644/fulldeliriumcognitive impairmentbiomarkersneuroinflammationolder people |
| spellingShingle | Lucía Lozano-Vicario Antonio García-Hermoso Bernardo Abel Cedeno-Veloz Joaquín Fernández-Irigoyen Enrique Santamaría Román Romero-Ortuno Fabricio Zambom-Ferraresi Fabricio Zambom-Ferraresi Mikel L. Sáez de Asteasu Ángel Javier Muñoz-Vázquez Mikel Izquierdo Mikel Izquierdo Nicolás Martínez-Velilla Nicolás Martínez-Velilla Nicolás Martínez-Velilla Biomarkers of delirium risk in older adults: a systematic review and meta-analysis Frontiers in Aging Neuroscience delirium cognitive impairment biomarkers neuroinflammation older people |
| title | Biomarkers of delirium risk in older adults: a systematic review and meta-analysis |
| title_full | Biomarkers of delirium risk in older adults: a systematic review and meta-analysis |
| title_fullStr | Biomarkers of delirium risk in older adults: a systematic review and meta-analysis |
| title_full_unstemmed | Biomarkers of delirium risk in older adults: a systematic review and meta-analysis |
| title_short | Biomarkers of delirium risk in older adults: a systematic review and meta-analysis |
| title_sort | biomarkers of delirium risk in older adults a systematic review and meta analysis |
| topic | delirium cognitive impairment biomarkers neuroinflammation older people |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1174644/full |
| work_keys_str_mv | AT lucialozanovicario biomarkersofdeliriumriskinolderadultsasystematicreviewandmetaanalysis AT antoniogarciahermoso biomarkersofdeliriumriskinolderadultsasystematicreviewandmetaanalysis AT bernardoabelcedenoveloz biomarkersofdeliriumriskinolderadultsasystematicreviewandmetaanalysis AT joaquinfernandezirigoyen biomarkersofdeliriumriskinolderadultsasystematicreviewandmetaanalysis AT enriquesantamaria biomarkersofdeliriumriskinolderadultsasystematicreviewandmetaanalysis AT romanromeroortuno biomarkersofdeliriumriskinolderadultsasystematicreviewandmetaanalysis AT fabriciozambomferraresi biomarkersofdeliriumriskinolderadultsasystematicreviewandmetaanalysis AT fabriciozambomferraresi biomarkersofdeliriumriskinolderadultsasystematicreviewandmetaanalysis AT mikellsaezdeasteasu biomarkersofdeliriumriskinolderadultsasystematicreviewandmetaanalysis AT angeljaviermunozvazquez biomarkersofdeliriumriskinolderadultsasystematicreviewandmetaanalysis AT mikelizquierdo biomarkersofdeliriumriskinolderadultsasystematicreviewandmetaanalysis AT mikelizquierdo biomarkersofdeliriumriskinolderadultsasystematicreviewandmetaanalysis AT nicolasmartinezvelilla biomarkersofdeliriumriskinolderadultsasystematicreviewandmetaanalysis AT nicolasmartinezvelilla biomarkersofdeliriumriskinolderadultsasystematicreviewandmetaanalysis AT nicolasmartinezvelilla biomarkersofdeliriumriskinolderadultsasystematicreviewandmetaanalysis |