The Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases?
The aryl hydrocarbon receptor (AHR) is a cytoplasmic transcription factor that is well-known for regulating xenobiotic metabolism. Studies in knockout and transgenic mice indicate that the AHR plays a vital role in the development of liver and regulation of reproductive, cardiovascular, hematopoieti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/3/1516 |
| _version_ | 1797487408678174720 |
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| author | Binoy Shivanna Chun Chu Bhagavatula Moorthy |
| author_facet | Binoy Shivanna Chun Chu Bhagavatula Moorthy |
| author_sort | Binoy Shivanna |
| collection | DOAJ |
| description | The aryl hydrocarbon receptor (AHR) is a cytoplasmic transcription factor that is well-known for regulating xenobiotic metabolism. Studies in knockout and transgenic mice indicate that the AHR plays a vital role in the development of liver and regulation of reproductive, cardiovascular, hematopoietic, and immune homeostasis. In this focused review on lung diseases associated with acute injury and alveolar development, we reviewed and summarized the current literature on the mechanistic role(s) and therapeutic potential of the AHR in acute lung injury, chronic obstructive pulmonary disease, and bronchopulmonary dysplasia (BPD). Pre-clinical studies indicate that endogenous AHR activation is necessary to protect neonatal and adult lungs against hyperoxia- and cigarette smoke-induced injury. Our goal is to provide insight into the high translational potential of the AHR in the meaningful management of infants and adults with these lung disorders that lack curative therapies. |
| first_indexed | 2024-03-09T23:47:13Z |
| format | Article |
| id | doaj.art-e3e25b32202c4179afb5a42761918e44 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:47:13Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e3e25b32202c4179afb5a42761918e442023-11-23T16:41:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-01233151610.3390/ijms23031516The Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases?Binoy Shivanna0Chun Chu1Bhagavatula Moorthy2Division of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USADivision of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USADivision of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USAThe aryl hydrocarbon receptor (AHR) is a cytoplasmic transcription factor that is well-known for regulating xenobiotic metabolism. Studies in knockout and transgenic mice indicate that the AHR plays a vital role in the development of liver and regulation of reproductive, cardiovascular, hematopoietic, and immune homeostasis. In this focused review on lung diseases associated with acute injury and alveolar development, we reviewed and summarized the current literature on the mechanistic role(s) and therapeutic potential of the AHR in acute lung injury, chronic obstructive pulmonary disease, and bronchopulmonary dysplasia (BPD). Pre-clinical studies indicate that endogenous AHR activation is necessary to protect neonatal and adult lungs against hyperoxia- and cigarette smoke-induced injury. Our goal is to provide insight into the high translational potential of the AHR in the meaningful management of infants and adults with these lung disorders that lack curative therapies.https://www.mdpi.com/1422-0067/23/3/1516aryl hydrocarbon receptorhyperoxiaacute lung injurychronic obstructive pulmonary diseaseand bronchopulmonary dysplasia |
| spellingShingle | Binoy Shivanna Chun Chu Bhagavatula Moorthy The Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases? International Journal of Molecular Sciences aryl hydrocarbon receptor hyperoxia acute lung injury chronic obstructive pulmonary disease and bronchopulmonary dysplasia |
| title | The Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases? |
| title_full | The Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases? |
| title_fullStr | The Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases? |
| title_full_unstemmed | The Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases? |
| title_short | The Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases? |
| title_sort | aryl hydrocarbon receptor ahr a novel therapeutic target for pulmonary diseases |
| topic | aryl hydrocarbon receptor hyperoxia acute lung injury chronic obstructive pulmonary disease and bronchopulmonary dysplasia |
| url | https://www.mdpi.com/1422-0067/23/3/1516 |
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