Correlation of slow‐wave sleep with motor and nonmotor progression in Parkinson's disease
Abstract Objective This study aimed to explore the association between slow‐wave sleep and the progression of motor and nonmotor symptoms in patients with PD. Methods Data were collected from the Parkinson's Progression Markers Initiative study. Slow‐wave sleep, also known as deep non‐rapid eye...
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51975 |
| _version_ | 1797245017792708608 |
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| author | Jing Chen Danhua Zhao Baoyu Chen Qi Wang Yuan Li Junyi Chen Chaobo Bai Xintong Guo Xiaotong Feng Xiaoyu He Lin Zhang Junliang Yuan |
| author_facet | Jing Chen Danhua Zhao Baoyu Chen Qi Wang Yuan Li Junyi Chen Chaobo Bai Xintong Guo Xiaotong Feng Xiaoyu He Lin Zhang Junliang Yuan |
| author_sort | Jing Chen |
| collection | DOAJ |
| description | Abstract Objective This study aimed to explore the association between slow‐wave sleep and the progression of motor and nonmotor symptoms in patients with PD. Methods Data were collected from the Parkinson's Progression Markers Initiative study. Slow‐wave sleep, also known as deep non‐rapid eye movement (DNREM) sleep, was objectively assessed using the Verily Study Watch. Motor function was assessed using the Movement Disorder Society‐Unified Parkinson's Disease Rating Scale Part III score, Hoehn and Yahr stage, freezing of gait, motor fluctuations, and dyskinesia severity. Comprehensive assessments were conducted on nonmotor symptoms, including depression, anxiety, global cognitive function, and autonomic dysfunction. Statistical analyses involved repeated‐measures analysis of variance and linear regression. Results A total of 102 patients with PD were included in the study, with a median follow‐up duration of 3.4 years. In the long DNREM sleep duration group (n = 55), better motor function (DNREM × time interaction: F(1,100) = 4.866, p = 0.030), less severe sexual dysfunction (p = 0.026), and improved activities of daily living (p = 0.033) were observed at the last follow‐up visit compared with the short DNREM sleep duration group (n = 47). Reduced DNREM sleep duration is a risk factor for motor progression (β = −0.251, p = 0.021; 95% confidence interval = −0.465 to −0.038). Interpretation The findings suggest an association between longer DNREM sleep duration and slower motor and nonmotor progression in patients with PD. |
| first_indexed | 2024-04-24T19:20:13Z |
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| id | doaj.art-e3e328c06d40405493e2fb0e9cac2386 |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-04-24T19:20:13Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-e3e328c06d40405493e2fb0e9cac23862024-03-26T03:13:57ZengWileyAnnals of Clinical and Translational Neurology2328-95032024-03-0111355456310.1002/acn3.51975Correlation of slow‐wave sleep with motor and nonmotor progression in Parkinson's diseaseJing Chen0Danhua Zhao1Baoyu Chen2Qi Wang3Yuan Li4Junyi Chen5Chaobo Bai6Xintong Guo7Xiaotong Feng8Xiaoyu He9Lin Zhang10Junliang Yuan11Department of Neurology Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Beijing 100191 ChinaDepartment of Neurology Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Beijing 100191 ChinaDepartment of Neurology Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Beijing 100191 ChinaDepartment of Neurology Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Beijing 100191 ChinaDepartment of Neurology Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Beijing 100191 ChinaDepartment of Neurology Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Beijing 100191 ChinaDepartment of Neurology Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Beijing 100191 ChinaDepartment of Neurology Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Beijing 100191 ChinaDepartment of Neurology Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Beijing 100191 ChinaDepartment of Neurology Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Beijing 100191 ChinaPF Center of Excellence, Department of Neurology UC Davis Medical Center, UC Davis School of Medicine Sacramento California USADepartment of Neurology Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Beijing 100191 ChinaAbstract Objective This study aimed to explore the association between slow‐wave sleep and the progression of motor and nonmotor symptoms in patients with PD. Methods Data were collected from the Parkinson's Progression Markers Initiative study. Slow‐wave sleep, also known as deep non‐rapid eye movement (DNREM) sleep, was objectively assessed using the Verily Study Watch. Motor function was assessed using the Movement Disorder Society‐Unified Parkinson's Disease Rating Scale Part III score, Hoehn and Yahr stage, freezing of gait, motor fluctuations, and dyskinesia severity. Comprehensive assessments were conducted on nonmotor symptoms, including depression, anxiety, global cognitive function, and autonomic dysfunction. Statistical analyses involved repeated‐measures analysis of variance and linear regression. Results A total of 102 patients with PD were included in the study, with a median follow‐up duration of 3.4 years. In the long DNREM sleep duration group (n = 55), better motor function (DNREM × time interaction: F(1,100) = 4.866, p = 0.030), less severe sexual dysfunction (p = 0.026), and improved activities of daily living (p = 0.033) were observed at the last follow‐up visit compared with the short DNREM sleep duration group (n = 47). Reduced DNREM sleep duration is a risk factor for motor progression (β = −0.251, p = 0.021; 95% confidence interval = −0.465 to −0.038). Interpretation The findings suggest an association between longer DNREM sleep duration and slower motor and nonmotor progression in patients with PD.https://doi.org/10.1002/acn3.51975 |
| spellingShingle | Jing Chen Danhua Zhao Baoyu Chen Qi Wang Yuan Li Junyi Chen Chaobo Bai Xintong Guo Xiaotong Feng Xiaoyu He Lin Zhang Junliang Yuan Correlation of slow‐wave sleep with motor and nonmotor progression in Parkinson's disease Annals of Clinical and Translational Neurology |
| title | Correlation of slow‐wave sleep with motor and nonmotor progression in Parkinson's disease |
| title_full | Correlation of slow‐wave sleep with motor and nonmotor progression in Parkinson's disease |
| title_fullStr | Correlation of slow‐wave sleep with motor and nonmotor progression in Parkinson's disease |
| title_full_unstemmed | Correlation of slow‐wave sleep with motor and nonmotor progression in Parkinson's disease |
| title_short | Correlation of slow‐wave sleep with motor and nonmotor progression in Parkinson's disease |
| title_sort | correlation of slow wave sleep with motor and nonmotor progression in parkinson s disease |
| url | https://doi.org/10.1002/acn3.51975 |
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