The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach
Omega-3 polyunsaturated fatty acids (ω-3PUFAs) are introduced into parenteral nutrition (PN) as hepatoprotective but may be susceptible to the lipid peroxidation while olive oil (OO) is declared more peroxidation resistant. We aimed to estimate how the lipid composition of PN mixture affects plasma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/8/2351 |
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| author | Vit Kosek Marie Heczkova Frantisek Novak Eva Meisnerova Olga Novákova Jaroslav Zelenka Kamila Bechynska Nikola Vrzacova Jiri Suttnar Alzbeta Hlavackova Helena Dankova Miriam Bratova Nikola Daskova Hana Malinska Olena Oliyarnyk Petr Wohl Hana Bastova Jana Hajslova Monika Cahova |
| author_facet | Vit Kosek Marie Heczkova Frantisek Novak Eva Meisnerova Olga Novákova Jaroslav Zelenka Kamila Bechynska Nikola Vrzacova Jiri Suttnar Alzbeta Hlavackova Helena Dankova Miriam Bratova Nikola Daskova Hana Malinska Olena Oliyarnyk Petr Wohl Hana Bastova Jana Hajslova Monika Cahova |
| author_sort | Vit Kosek |
| collection | DOAJ |
| description | Omega-3 polyunsaturated fatty acids (ω-3PUFAs) are introduced into parenteral nutrition (PN) as hepatoprotective but may be susceptible to the lipid peroxidation while olive oil (OO) is declared more peroxidation resistant. We aimed to estimate how the lipid composition of PN mixture affects plasma and erythrocyte lipidome and the propensity of oxidative stress. A cross-sectional comparative study was performed in a cohort of adult patients who were long-term parenterally administered ω-3 PUFAs without (FO/–, <i>n</i> = 9) or with (FO/OO, <i>n</i> = 13) olive oil and healthy age- and sex-matched controls, (<i>n</i> = 30). Lipoperoxidation assessed as plasma and erythrocyte malondialdehyde content was increased in both FO/– and FO/OO groups but protein oxidative stress (protein carbonyls in plasma) and low redox status (GSH/GSSG in erythrocytes) was detected only in the FO/– subcohort. The lipidome of all subjects receiving ω-3 PUFAs was enriched with lipid species containing ω-3 PUFAs (FO/–˃FO/OO). Common characteristic of all PN-dependent patients was high content of fatty acyl-esters of hydroxy-fatty acids (FAHFAs) in plasma while acylcarnitines and ceramides were enriched in erythrocytes. Plasma and erythrocyte concentrations of plasmanyls and plasmalogens (endogenous antioxidants) were decreased in both patient groups with a significantly more pronounced effect in FO/–. We confirmed the protective effect of OO in PN mixtures containing ω-3 PUFAs. |
| first_indexed | 2024-03-10T17:54:21Z |
| format | Article |
| id | doaj.art-e3e543c3592b49c99235e66147484bf4 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T17:54:21Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e3e543c3592b49c99235e66147484bf42023-11-20T09:16:50ZengMDPI AGNutrients2072-66432020-08-01128235110.3390/nu12082351The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics ApproachVit Kosek0Marie Heczkova1Frantisek Novak2Eva Meisnerova3Olga Novákova4Jaroslav Zelenka5Kamila Bechynska6Nikola Vrzacova7Jiri Suttnar8Alzbeta Hlavackova9Helena Dankova10Miriam Bratova11Nikola Daskova12Hana Malinska13Olena Oliyarnyk14Petr Wohl15Hana Bastova16Jana Hajslova17Monika Cahova18University of Chemistry and Technology, 166 28 Prague, Czech RepublicCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic4th Department of Internal Medicine, 1st Faculty of Medicine and General University Hospital, Charles University, 128 08 Prague, Czech Republic4th Department of Internal Medicine, 1st Faculty of Medicine and General University Hospital, Charles University, 128 08 Prague, Czech RepublicDepartment of Physiology, Faculty of Science, Charles University in Prague, 128 00 Prague, Czech RepublicUniversity of Chemistry and Technology, 166 28 Prague, Czech RepublicUniversity of Chemistry and Technology, 166 28 Prague, Czech RepublicUniversity of Chemistry and Technology, 166 28 Prague, Czech RepublicInstitute of Hematology and Blood Transfusion, 128 20 Prague, Czech RepublicInstitute of Hematology and Blood Transfusion, 128 20 Prague, Czech RepublicCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicDiabetology Center, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicDiabetology Center, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicUniversity of Chemistry and Technology, 166 28 Prague, Czech RepublicCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech RepublicOmega-3 polyunsaturated fatty acids (ω-3PUFAs) are introduced into parenteral nutrition (PN) as hepatoprotective but may be susceptible to the lipid peroxidation while olive oil (OO) is declared more peroxidation resistant. We aimed to estimate how the lipid composition of PN mixture affects plasma and erythrocyte lipidome and the propensity of oxidative stress. A cross-sectional comparative study was performed in a cohort of adult patients who were long-term parenterally administered ω-3 PUFAs without (FO/–, <i>n</i> = 9) or with (FO/OO, <i>n</i> = 13) olive oil and healthy age- and sex-matched controls, (<i>n</i> = 30). Lipoperoxidation assessed as plasma and erythrocyte malondialdehyde content was increased in both FO/– and FO/OO groups but protein oxidative stress (protein carbonyls in plasma) and low redox status (GSH/GSSG in erythrocytes) was detected only in the FO/– subcohort. The lipidome of all subjects receiving ω-3 PUFAs was enriched with lipid species containing ω-3 PUFAs (FO/–˃FO/OO). Common characteristic of all PN-dependent patients was high content of fatty acyl-esters of hydroxy-fatty acids (FAHFAs) in plasma while acylcarnitines and ceramides were enriched in erythrocytes. Plasma and erythrocyte concentrations of plasmanyls and plasmalogens (endogenous antioxidants) were decreased in both patient groups with a significantly more pronounced effect in FO/–. We confirmed the protective effect of OO in PN mixtures containing ω-3 PUFAs.https://www.mdpi.com/2072-6643/12/8/2351home parenteral nutritionintestinal failurefish oilolive oiloxidative stresslipidomics |
| spellingShingle | Vit Kosek Marie Heczkova Frantisek Novak Eva Meisnerova Olga Novákova Jaroslav Zelenka Kamila Bechynska Nikola Vrzacova Jiri Suttnar Alzbeta Hlavackova Helena Dankova Miriam Bratova Nikola Daskova Hana Malinska Olena Oliyarnyk Petr Wohl Hana Bastova Jana Hajslova Monika Cahova The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach Nutrients home parenteral nutrition intestinal failure fish oil olive oil oxidative stress lipidomics |
| title | The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach |
| title_full | The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach |
| title_fullStr | The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach |
| title_full_unstemmed | The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach |
| title_short | The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach |
| title_sort | ω 3 polyunsaturated fatty acids and oxidative stress in long term parenteral nutrition dependent adult patients functional lipidomics approach |
| topic | home parenteral nutrition intestinal failure fish oil olive oil oxidative stress lipidomics |
| url | https://www.mdpi.com/2072-6643/12/8/2351 |
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