Comparative Pharmacokinetics Study of Sinomenine in Rats after Oral Administration of Sinomenine Monomer and Sinomenium Acutum Extract
Various products containing sinomenine monomer and extracts of Sinomenium acutum have been widely applied in clinical treatments. The goal of the present study was to compare the pharmacokinetics of sinomenine in rats after oral administration of sinomenine monomer and Sinomenium acutum extract, an...
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| Format: | Article |
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MDPI AG
2014-08-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/8/12065 |
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| author | Mao-Fan Zhang Yan Zhao Kun-Yu Jiang Long Han Xiao-Yue Lu Xin Wang Lan Zuo Sheng-Nan Meng |
| author_facet | Mao-Fan Zhang Yan Zhao Kun-Yu Jiang Long Han Xiao-Yue Lu Xin Wang Lan Zuo Sheng-Nan Meng |
| author_sort | Mao-Fan Zhang |
| collection | DOAJ |
| description | Various products containing sinomenine monomer and extracts of Sinomenium acutum have been widely applied in clinical treatments. The goal of the present study was to compare the pharmacokinetics of sinomenine in rats after oral administration of sinomenine monomer and Sinomenium acutum extract, and to attempt to explore potential component-component interactions between the constituents of this traditional Chinese herbal medicine. A reliable and specific reversed phase high performance liquid chromatography method was developed to analyze sinomenine in rat plasma. Pharmacokinetic parameters for sinomenine were processed by non-compartmental analysis. The results showed that the maximum concentration, the area under the concentration-time curve, clearance and the apparent volume of distribution of sinomenine in the Sinomenium acutum extract statistically differed from those of sinomenine monomer (p < 0.05); however, the mean residence time, time of peak concentration, and half-life did not show significant differences between the two groups. These findings suggested that some additional components in the Sinomenium acutum extract may decrease the absorption of sinomenine. The complex interactions between sinomenine and other components of the herbal extract could result in the altered pharmacokinetic behavior of sinomenine, which may subsequently cause different therapeutic and detoxification effects. |
| first_indexed | 2024-12-20T14:42:53Z |
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| id | doaj.art-e3e723e97d324f88973e177e0639df52 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T14:42:53Z |
| publishDate | 2014-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e3e723e97d324f88973e177e0639df522022-12-21T19:37:14ZengMDPI AGMolecules1420-30492014-08-01198120651207710.3390/molecules190812065molecules190812065Comparative Pharmacokinetics Study of Sinomenine in Rats after Oral Administration of Sinomenine Monomer and Sinomenium Acutum ExtractMao-Fan Zhang0Yan Zhao1Kun-Yu Jiang2Long Han3Xiao-Yue Lu4Xin Wang5Lan Zuo6Sheng-Nan Meng7Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, ChinaDepartment of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, ChinaDepartment of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, ChinaDepartment of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, ChinaDepartment of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, ChinaDepartment of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, ChinaDepartment of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, ChinaDepartment of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, ChinaVarious products containing sinomenine monomer and extracts of Sinomenium acutum have been widely applied in clinical treatments. The goal of the present study was to compare the pharmacokinetics of sinomenine in rats after oral administration of sinomenine monomer and Sinomenium acutum extract, and to attempt to explore potential component-component interactions between the constituents of this traditional Chinese herbal medicine. A reliable and specific reversed phase high performance liquid chromatography method was developed to analyze sinomenine in rat plasma. Pharmacokinetic parameters for sinomenine were processed by non-compartmental analysis. The results showed that the maximum concentration, the area under the concentration-time curve, clearance and the apparent volume of distribution of sinomenine in the Sinomenium acutum extract statistically differed from those of sinomenine monomer (p < 0.05); however, the mean residence time, time of peak concentration, and half-life did not show significant differences between the two groups. These findings suggested that some additional components in the Sinomenium acutum extract may decrease the absorption of sinomenine. The complex interactions between sinomenine and other components of the herbal extract could result in the altered pharmacokinetic behavior of sinomenine, which may subsequently cause different therapeutic and detoxification effects.http://www.mdpi.com/1420-3049/19/8/12065pharmacokineticstraditional Chinese medicinesinomenineSinomenium acutumalkaloidsHPLC |
| spellingShingle | Mao-Fan Zhang Yan Zhao Kun-Yu Jiang Long Han Xiao-Yue Lu Xin Wang Lan Zuo Sheng-Nan Meng Comparative Pharmacokinetics Study of Sinomenine in Rats after Oral Administration of Sinomenine Monomer and Sinomenium Acutum Extract Molecules pharmacokinetics traditional Chinese medicine sinomenine Sinomenium acutum alkaloids HPLC |
| title | Comparative Pharmacokinetics Study of Sinomenine in Rats after Oral Administration of Sinomenine Monomer and Sinomenium Acutum Extract |
| title_full | Comparative Pharmacokinetics Study of Sinomenine in Rats after Oral Administration of Sinomenine Monomer and Sinomenium Acutum Extract |
| title_fullStr | Comparative Pharmacokinetics Study of Sinomenine in Rats after Oral Administration of Sinomenine Monomer and Sinomenium Acutum Extract |
| title_full_unstemmed | Comparative Pharmacokinetics Study of Sinomenine in Rats after Oral Administration of Sinomenine Monomer and Sinomenium Acutum Extract |
| title_short | Comparative Pharmacokinetics Study of Sinomenine in Rats after Oral Administration of Sinomenine Monomer and Sinomenium Acutum Extract |
| title_sort | comparative pharmacokinetics study of sinomenine in rats after oral administration of sinomenine monomer and sinomenium acutum extract |
| topic | pharmacokinetics traditional Chinese medicine sinomenine Sinomenium acutum alkaloids HPLC |
| url | http://www.mdpi.com/1420-3049/19/8/12065 |
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