A Markov-model simulation of IVF programs for PCOS patients indicates that coupling myo-Inositol with rFSH is cost-effective for the Italian Health System
Abstract Accumulating evidence suggests that oral supplementation with myo-Inositol (myo-Ins) is able to reduce the amount of gonadotropins and days of controlled ovarian hyperstimulation (COS) necessary to achieve adequate oocyte maturation in assisted reproduction technology (ART) protocols, parti...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-44055-0 |
| _version_ | 1797559797498773504 |
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| author | Ariel Beresniak Michele Russo Gianpiero Forte Antonio Simone Laganà Mario Montanino Oliva Cesare Aragona Vito Chiantera Vittorio Unfer |
| author_facet | Ariel Beresniak Michele Russo Gianpiero Forte Antonio Simone Laganà Mario Montanino Oliva Cesare Aragona Vito Chiantera Vittorio Unfer |
| author_sort | Ariel Beresniak |
| collection | DOAJ |
| description | Abstract Accumulating evidence suggests that oral supplementation with myo-Inositol (myo-Ins) is able to reduce the amount of gonadotropins and days of controlled ovarian hyperstimulation (COS) necessary to achieve adequate oocyte maturation in assisted reproduction technology (ART) protocols, particularly in women affected by polycystic ovary syndrome (PCOS). We used computational calculations based on simulation modellings. We simulated in vitro fertilization (IVF) procedures—with or without intracytoplasmic sperm injection (ICSI)—with 100,000 virtual patients, accounting for all the stages of the entire IVF procedure. A Monte Carlo technique was used to account for data uncertainty and to generate the outcome distribution at each stage. We considered virtual patients with PCOS undergoing IVF cycles to achieve pregnancy. Computational data were retrieved from clinical experience and published data. We investigated three parameters related to ART protocols: cost of single procedure; efficacy to achieve ongoing pregnancy at 12 gestational weeks; overall cost per single pregnancy. The administration of oral myo-Ins during COH protocols, compared to the standard COH with recombinant Follicle Stimulating Hormone (rFSH) only, may be considered a potential strategy to reduce costs of ART for the Italian Health System. |
| first_indexed | 2024-03-10T17:50:20Z |
| format | Article |
| id | doaj.art-e3e72e0a84ac40a9a428913844904c31 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:50:20Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e3e72e0a84ac40a9a428913844904c312023-11-20T09:23:49ZengNature PortfolioScientific Reports2045-23222023-10-011311810.1038/s41598-023-44055-0A Markov-model simulation of IVF programs for PCOS patients indicates that coupling myo-Inositol with rFSH is cost-effective for the Italian Health SystemAriel Beresniak0Michele Russo1Gianpiero Forte2Antonio Simone Laganà3Mario Montanino Oliva4Cesare Aragona5Vito Chiantera6Vittorio Unfer7Data Mining International SAR&D Department, Lo.Li. PharmaR&D Department, Lo.Li. PharmaThe Experts Group on Inositol in Basic and Clinical Research (EGOI)The Experts Group on Inositol in Basic and Clinical Research (EGOI)The Experts Group on Inositol in Basic and Clinical Research (EGOI)Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of PalermoThe Experts Group on Inositol in Basic and Clinical Research (EGOI)Abstract Accumulating evidence suggests that oral supplementation with myo-Inositol (myo-Ins) is able to reduce the amount of gonadotropins and days of controlled ovarian hyperstimulation (COS) necessary to achieve adequate oocyte maturation in assisted reproduction technology (ART) protocols, particularly in women affected by polycystic ovary syndrome (PCOS). We used computational calculations based on simulation modellings. We simulated in vitro fertilization (IVF) procedures—with or without intracytoplasmic sperm injection (ICSI)—with 100,000 virtual patients, accounting for all the stages of the entire IVF procedure. A Monte Carlo technique was used to account for data uncertainty and to generate the outcome distribution at each stage. We considered virtual patients with PCOS undergoing IVF cycles to achieve pregnancy. Computational data were retrieved from clinical experience and published data. We investigated three parameters related to ART protocols: cost of single procedure; efficacy to achieve ongoing pregnancy at 12 gestational weeks; overall cost per single pregnancy. The administration of oral myo-Ins during COH protocols, compared to the standard COH with recombinant Follicle Stimulating Hormone (rFSH) only, may be considered a potential strategy to reduce costs of ART for the Italian Health System.https://doi.org/10.1038/s41598-023-44055-0 |
| spellingShingle | Ariel Beresniak Michele Russo Gianpiero Forte Antonio Simone Laganà Mario Montanino Oliva Cesare Aragona Vito Chiantera Vittorio Unfer A Markov-model simulation of IVF programs for PCOS patients indicates that coupling myo-Inositol with rFSH is cost-effective for the Italian Health System Scientific Reports |
| title | A Markov-model simulation of IVF programs for PCOS patients indicates that coupling myo-Inositol with rFSH is cost-effective for the Italian Health System |
| title_full | A Markov-model simulation of IVF programs for PCOS patients indicates that coupling myo-Inositol with rFSH is cost-effective for the Italian Health System |
| title_fullStr | A Markov-model simulation of IVF programs for PCOS patients indicates that coupling myo-Inositol with rFSH is cost-effective for the Italian Health System |
| title_full_unstemmed | A Markov-model simulation of IVF programs for PCOS patients indicates that coupling myo-Inositol with rFSH is cost-effective for the Italian Health System |
| title_short | A Markov-model simulation of IVF programs for PCOS patients indicates that coupling myo-Inositol with rFSH is cost-effective for the Italian Health System |
| title_sort | markov model simulation of ivf programs for pcos patients indicates that coupling myo inositol with rfsh is cost effective for the italian health system |
| url | https://doi.org/10.1038/s41598-023-44055-0 |
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