Two New Cinnamyl Isovalerate Derivatives from Sabina gaussenii
Chemical investigation of the 90% acetone extract of the branches and leaves of Sabina gaussenii led to the isolation of two new cinnamyl isovalerate derivatives (1–2) and eighteen known compounds (3–20). Their structures were determined mainly by means of MS, 1D- and 2D-NMR data, and this is the fi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-04-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/5/571 |
| _version_ | 1818970841167167488 |
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| author | Zhang-Hua Sun Ning-Hua Tan Guang-Zhi Zeng Yu-Mei Zhang |
| author_facet | Zhang-Hua Sun Ning-Hua Tan Guang-Zhi Zeng Yu-Mei Zhang |
| author_sort | Zhang-Hua Sun |
| collection | DOAJ |
| description | Chemical investigation of the 90% acetone extract of the branches and leaves of Sabina gaussenii led to the isolation of two new cinnamyl isovalerate derivatives (1–2) and eighteen known compounds (3–20). Their structures were determined mainly by means of MS, 1D- and 2D-NMR data, and this is the first time these compounds have been reported from this plant. The biological activity test results indicated that the 90% acetone extract showed cytotoxicity against the human lung adenocarcinoma (A549) cell line (IC50 = 0.98 ± 0.1 μg/mL), compound 6 showed cytotoxicities against human cervical carcinoma (HeLa) (IC50 = 0.4 ± 0.1 μM ) and human gastric carcinoma (BGC-823) (IC50 = 0.9 ± 0.2 μM) cancer cell lines, and compound 19 showed cytotoxicities against HeLa (IC50 = 1.5 ± 0.4 μM), BGC-823 (IC50 = 7.0 ± 0.8 μM ), and A549 (IC50 = 10.6 ± 1.5 μM ) cancer cell lines. |
| first_indexed | 2024-12-20T14:42:53Z |
| format | Article |
| id | doaj.art-e3e76a07e87d4cf89b693e7d3752c86f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T14:42:53Z |
| publishDate | 2016-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e3e76a07e87d4cf89b693e7d3752c86f2022-12-21T19:37:14ZengMDPI AGMolecules1420-30492016-04-0121557110.3390/molecules21050571molecules21050571Two New Cinnamyl Isovalerate Derivatives from Sabina gausseniiZhang-Hua Sun0Ning-Hua Tan1Guang-Zhi Zeng2Yu-Mei Zhang3Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, ChinaKey Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223, ChinaChemical investigation of the 90% acetone extract of the branches and leaves of Sabina gaussenii led to the isolation of two new cinnamyl isovalerate derivatives (1–2) and eighteen known compounds (3–20). Their structures were determined mainly by means of MS, 1D- and 2D-NMR data, and this is the first time these compounds have been reported from this plant. The biological activity test results indicated that the 90% acetone extract showed cytotoxicity against the human lung adenocarcinoma (A549) cell line (IC50 = 0.98 ± 0.1 μg/mL), compound 6 showed cytotoxicities against human cervical carcinoma (HeLa) (IC50 = 0.4 ± 0.1 μM ) and human gastric carcinoma (BGC-823) (IC50 = 0.9 ± 0.2 μM) cancer cell lines, and compound 19 showed cytotoxicities against HeLa (IC50 = 1.5 ± 0.4 μM), BGC-823 (IC50 = 7.0 ± 0.8 μM ), and A549 (IC50 = 10.6 ± 1.5 μM ) cancer cell lines.http://www.mdpi.com/1420-3049/21/5/571Sabina gausseniicinnamyl isovaleratecytotoxicity |
| spellingShingle | Zhang-Hua Sun Ning-Hua Tan Guang-Zhi Zeng Yu-Mei Zhang Two New Cinnamyl Isovalerate Derivatives from Sabina gaussenii Molecules Sabina gaussenii cinnamyl isovalerate cytotoxicity |
| title | Two New Cinnamyl Isovalerate Derivatives from Sabina gaussenii |
| title_full | Two New Cinnamyl Isovalerate Derivatives from Sabina gaussenii |
| title_fullStr | Two New Cinnamyl Isovalerate Derivatives from Sabina gaussenii |
| title_full_unstemmed | Two New Cinnamyl Isovalerate Derivatives from Sabina gaussenii |
| title_short | Two New Cinnamyl Isovalerate Derivatives from Sabina gaussenii |
| title_sort | two new cinnamyl isovalerate derivatives from sabina gaussenii |
| topic | Sabina gaussenii cinnamyl isovalerate cytotoxicity |
| url | http://www.mdpi.com/1420-3049/21/5/571 |
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