| Summary: | Development of functional bioinspired hydrogels that have good releases control character is necessary for the application of these materials in biomedical engineering. Herein, we report a composite hydrogel prepared from several biocompatible carboxymethyl konjac glucomannan (CKGM)/gelatin (G)/tannic acid (TA) functional nano-hydroxyapatite (TA@n-HA), which has good biodegradability and pH sensitivity. The mechanism of interaction between hydrogels was confirmed by Fourier transform infrared spectroscopy, X-ray diffraction, Scanning electron microscopy and Thermogravimetric analysis. The physico-chemical properties of CKGM/G hydrogels have been significantly improved through the incorporation of TA@n-HA within the matrix. Studies in the sustained release of epigallocatechin gallate (EGCG) demonstrated that the TA@n-HA/CKGM/G hydrogels exhibit not only better pH sensitive properties, but also enhanced biocompatibility and encapsulation in comparison to the matrix devoid of TA@n-HA. Consequently, TA@n-HA/CKGM/G hydrogels using EGCG as a drug release model show the potential for drug delivery.
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