Formation of composite hydrogel of carboxymethyl konjac glucomannan/gelatin for sustained release of EGCG
Development of functional bioinspired hydrogels that have good releases control character is necessary for the application of these materials in biomedical engineering. Herein, we report a composite hydrogel prepared from several biocompatible carboxymethyl konjac glucomannan (CKGM)/gelatin (G)/tann...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2022-09-01
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| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022000805 |
| _version_ | 1797721013204549632 |
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| author | Lin Wang Ning Zhou Shengxuan Zheng Jie Pang |
| author_facet | Lin Wang Ning Zhou Shengxuan Zheng Jie Pang |
| author_sort | Lin Wang |
| collection | DOAJ |
| description | Development of functional bioinspired hydrogels that have good releases control character is necessary for the application of these materials in biomedical engineering. Herein, we report a composite hydrogel prepared from several biocompatible carboxymethyl konjac glucomannan (CKGM)/gelatin (G)/tannic acid (TA) functional nano-hydroxyapatite (TA@n-HA), which has good biodegradability and pH sensitivity. The mechanism of interaction between hydrogels was confirmed by Fourier transform infrared spectroscopy, X-ray diffraction, Scanning electron microscopy and Thermogravimetric analysis. The physico-chemical properties of CKGM/G hydrogels have been significantly improved through the incorporation of TA@n-HA within the matrix. Studies in the sustained release of epigallocatechin gallate (EGCG) demonstrated that the TA@n-HA/CKGM/G hydrogels exhibit not only better pH sensitive properties, but also enhanced biocompatibility and encapsulation in comparison to the matrix devoid of TA@n-HA. Consequently, TA@n-HA/CKGM/G hydrogels using EGCG as a drug release model show the potential for drug delivery. |
| first_indexed | 2024-03-12T09:28:43Z |
| format | Article |
| id | doaj.art-e3e795c721fc4ceab57ca30f8d5e912f |
| institution | Directory Open Access Journal |
| issn | 2213-4530 |
| language | English |
| last_indexed | 2024-03-12T09:28:43Z |
| publishDate | 2022-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj.art-e3e795c721fc4ceab57ca30f8d5e912f2023-09-02T14:04:07ZengTsinghua University PressFood Science and Human Wellness2213-45302022-09-0111513731383Formation of composite hydrogel of carboxymethyl konjac glucomannan/gelatin for sustained release of EGCGLin Wang0Ning Zhou1Shengxuan Zheng2Jie Pang3Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China; Institute of Superlubricity Technology, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, China; Corresponding author at: Department of Engineering Mechanics, Tsinghua University, Beijing 100084, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Corresponding author.Development of functional bioinspired hydrogels that have good releases control character is necessary for the application of these materials in biomedical engineering. Herein, we report a composite hydrogel prepared from several biocompatible carboxymethyl konjac glucomannan (CKGM)/gelatin (G)/tannic acid (TA) functional nano-hydroxyapatite (TA@n-HA), which has good biodegradability and pH sensitivity. The mechanism of interaction between hydrogels was confirmed by Fourier transform infrared spectroscopy, X-ray diffraction, Scanning electron microscopy and Thermogravimetric analysis. The physico-chemical properties of CKGM/G hydrogels have been significantly improved through the incorporation of TA@n-HA within the matrix. Studies in the sustained release of epigallocatechin gallate (EGCG) demonstrated that the TA@n-HA/CKGM/G hydrogels exhibit not only better pH sensitive properties, but also enhanced biocompatibility and encapsulation in comparison to the matrix devoid of TA@n-HA. Consequently, TA@n-HA/CKGM/G hydrogels using EGCG as a drug release model show the potential for drug delivery.http://www.sciencedirect.com/science/article/pii/S2213453022000805HydrogelCarboxymethyl konjac glucomannanGelatinTannic acidBiodegradationSustained release |
| spellingShingle | Lin Wang Ning Zhou Shengxuan Zheng Jie Pang Formation of composite hydrogel of carboxymethyl konjac glucomannan/gelatin for sustained release of EGCG Food Science and Human Wellness Hydrogel Carboxymethyl konjac glucomannan Gelatin Tannic acid Biodegradation Sustained release |
| title | Formation of composite hydrogel of carboxymethyl konjac glucomannan/gelatin for sustained release of EGCG |
| title_full | Formation of composite hydrogel of carboxymethyl konjac glucomannan/gelatin for sustained release of EGCG |
| title_fullStr | Formation of composite hydrogel of carboxymethyl konjac glucomannan/gelatin for sustained release of EGCG |
| title_full_unstemmed | Formation of composite hydrogel of carboxymethyl konjac glucomannan/gelatin for sustained release of EGCG |
| title_short | Formation of composite hydrogel of carboxymethyl konjac glucomannan/gelatin for sustained release of EGCG |
| title_sort | formation of composite hydrogel of carboxymethyl konjac glucomannan gelatin for sustained release of egcg |
| topic | Hydrogel Carboxymethyl konjac glucomannan Gelatin Tannic acid Biodegradation Sustained release |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022000805 |
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