Endothelial Cell Plasma Membrane Biomechanics Mediates Effects of Pro-Inflammatory Factors on Endothelial Mechanosensors: Vicious Circle Formation in Atherogenic Inflammation
Chronic low-grade vascular inflammation and endothelial dysfunction significantly contribute to the pathogenesis of cardiovascular diseases. In endothelial cells (ECs), anti-inflammatory or pro-inflammatory signaling can be induced by different patterns of the fluid shear stress (SS) exerted by bloo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Membranes |
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| Online Access: | https://www.mdpi.com/2077-0375/12/2/205 |
| _version_ | 1797478160535650304 |
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| author | Nadezhda Barvitenko Mohammad Ashrafuzzaman Alfons Lawen Elisaveta Skverchinskaya Carlota Saldanha Alessia Manca Giuseppe Uras Muhammad Aslam Antonella Pantaleo |
| author_facet | Nadezhda Barvitenko Mohammad Ashrafuzzaman Alfons Lawen Elisaveta Skverchinskaya Carlota Saldanha Alessia Manca Giuseppe Uras Muhammad Aslam Antonella Pantaleo |
| author_sort | Nadezhda Barvitenko |
| collection | DOAJ |
| description | Chronic low-grade vascular inflammation and endothelial dysfunction significantly contribute to the pathogenesis of cardiovascular diseases. In endothelial cells (ECs), anti-inflammatory or pro-inflammatory signaling can be induced by different patterns of the fluid shear stress (SS) exerted by blood flow on ECs. Laminar blood flow with high magnitude is anti-inflammatory, while disturbed flow and laminar flow with low magnitude is pro-inflammatory. Endothelial mechanosensors are the key upstream signaling proteins in SS-induced pro- and anti-inflammatory responses. Being transmembrane proteins, mechanosensors, not only experience fluid SS but also become regulated by the biomechanical properties of the lipid bilayer and the cytoskeleton. We review the apparent effects of pro-inflammatory factors (hypoxia, oxidative stress, hypercholesterolemia, and cytokines) on the biomechanics of the lipid bilayer and the cytoskeleton. An analysis of the available data suggests that the formation of a vicious circle may occur, in which pro-inflammatory cytokines enhance and attenuate SS-induced pro-inflammatory and anti-inflammatory signaling, respectively. |
| first_indexed | 2024-03-09T21:29:01Z |
| format | Article |
| id | doaj.art-e3e9d596859f49c89389906419425776 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-09T21:29:01Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-e3e9d596859f49c893899064194257762023-11-23T21:03:32ZengMDPI AGMembranes2077-03752022-02-0112220510.3390/membranes12020205Endothelial Cell Plasma Membrane Biomechanics Mediates Effects of Pro-Inflammatory Factors on Endothelial Mechanosensors: Vicious Circle Formation in Atherogenic InflammationNadezhda Barvitenko0Mohammad Ashrafuzzaman1Alfons Lawen2Elisaveta Skverchinskaya3Carlota Saldanha4Alessia Manca5Giuseppe Uras6Muhammad Aslam7Antonella Pantaleo8Independent Researcher, 191014 Saint-Petersburg, RussiaDepartment of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Melbourne, VIC 3800, AustraliaSechenov Institute of Evolutionary Physiology and Biochemistry, 194223 Saint-Petersburg, RussiaInstitute of Biochemistry, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, 1649-028 Lisboa, PortugalDepartment of Biomedical Science, University of Sassari, 07100 Sassari, ItalyDepartment of Clinical and Movement Neurosciences, Institute of Neurology, University College London, London NW3 2PF, UKExperimental Cardiology, Department of Cardiology/Angiology, Justus Liebig University, 35392 Giessen, GermanyDepartment of Biomedical Science, University of Sassari, 07100 Sassari, ItalyChronic low-grade vascular inflammation and endothelial dysfunction significantly contribute to the pathogenesis of cardiovascular diseases. In endothelial cells (ECs), anti-inflammatory or pro-inflammatory signaling can be induced by different patterns of the fluid shear stress (SS) exerted by blood flow on ECs. Laminar blood flow with high magnitude is anti-inflammatory, while disturbed flow and laminar flow with low magnitude is pro-inflammatory. Endothelial mechanosensors are the key upstream signaling proteins in SS-induced pro- and anti-inflammatory responses. Being transmembrane proteins, mechanosensors, not only experience fluid SS but also become regulated by the biomechanical properties of the lipid bilayer and the cytoskeleton. We review the apparent effects of pro-inflammatory factors (hypoxia, oxidative stress, hypercholesterolemia, and cytokines) on the biomechanics of the lipid bilayer and the cytoskeleton. An analysis of the available data suggests that the formation of a vicious circle may occur, in which pro-inflammatory cytokines enhance and attenuate SS-induced pro-inflammatory and anti-inflammatory signaling, respectively.https://www.mdpi.com/2077-0375/12/2/205shear stressinflammationendothelial celllipid bilayercytoskeletonmechanosensor |
| spellingShingle | Nadezhda Barvitenko Mohammad Ashrafuzzaman Alfons Lawen Elisaveta Skverchinskaya Carlota Saldanha Alessia Manca Giuseppe Uras Muhammad Aslam Antonella Pantaleo Endothelial Cell Plasma Membrane Biomechanics Mediates Effects of Pro-Inflammatory Factors on Endothelial Mechanosensors: Vicious Circle Formation in Atherogenic Inflammation Membranes shear stress inflammation endothelial cell lipid bilayer cytoskeleton mechanosensor |
| title | Endothelial Cell Plasma Membrane Biomechanics Mediates Effects of Pro-Inflammatory Factors on Endothelial Mechanosensors: Vicious Circle Formation in Atherogenic Inflammation |
| title_full | Endothelial Cell Plasma Membrane Biomechanics Mediates Effects of Pro-Inflammatory Factors on Endothelial Mechanosensors: Vicious Circle Formation in Atherogenic Inflammation |
| title_fullStr | Endothelial Cell Plasma Membrane Biomechanics Mediates Effects of Pro-Inflammatory Factors on Endothelial Mechanosensors: Vicious Circle Formation in Atherogenic Inflammation |
| title_full_unstemmed | Endothelial Cell Plasma Membrane Biomechanics Mediates Effects of Pro-Inflammatory Factors on Endothelial Mechanosensors: Vicious Circle Formation in Atherogenic Inflammation |
| title_short | Endothelial Cell Plasma Membrane Biomechanics Mediates Effects of Pro-Inflammatory Factors on Endothelial Mechanosensors: Vicious Circle Formation in Atherogenic Inflammation |
| title_sort | endothelial cell plasma membrane biomechanics mediates effects of pro inflammatory factors on endothelial mechanosensors vicious circle formation in atherogenic inflammation |
| topic | shear stress inflammation endothelial cell lipid bilayer cytoskeleton mechanosensor |
| url | https://www.mdpi.com/2077-0375/12/2/205 |
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