Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion Functions
In this work, we designed and fabricated a multifunctional nanocomposite system that consists of chitosan, raspberry-like silver nanoparticles, and graphene oxide. The room temperature atmospheric pressure microplasma (RT-APM) process provides a rapid, facile, and environmentally-friendly method for...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/14/9/2351 |
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| author | Zheng Su Daye Sun Li Zhang Miaomiao He Yulin Jiang Bronagh Millar Paula Douglas Davide Mariotti Paul Maguire Dan Sun |
| author_facet | Zheng Su Daye Sun Li Zhang Miaomiao He Yulin Jiang Bronagh Millar Paula Douglas Davide Mariotti Paul Maguire Dan Sun |
| author_sort | Zheng Su |
| collection | DOAJ |
| description | In this work, we designed and fabricated a multifunctional nanocomposite system that consists of chitosan, raspberry-like silver nanoparticles, and graphene oxide. The room temperature atmospheric pressure microplasma (RT-APM) process provides a rapid, facile, and environmentally-friendly method for introducing silver nanoparticles into the composite system. Our composite can achieve a pH controlled single and/or dual drug release. Under pH 7.4 for methyl blue loaded on chitosan, the drug release profile features a burst release during the first 10 h, followed by a more stabilized release of 70–80% after 40–50 h. For fluorescein sodium loaded on graphene oxide, the drug release only reached 45% towards the end of 240 h. When the composite acted as a dual drug release system, the interaction of fluorescein sodium and methyl blue slowed down the methyl blue release rate. Under pH 4, both single and dual drug systems showed a much higher release rate. In addition, our composite system demonstrated strong antibacterial abilities against <i>E. coli</i> and <i>S. aureus</i>, as well as an excellent photothermal conversion effect under irradiation of near infrared lasers. The photothermal conversion efficiency can be controlled by the laser power. These unique functionalities of our nanocomposite point to its potential application in multiple areas, such as multimodal therapeutics in healthcare, water treatment, and anti-microbials, among others. |
| first_indexed | 2024-03-10T11:46:41Z |
| format | Article |
| id | doaj.art-e3eac45f961d4bed9128d87b00d0adbc |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T11:46:41Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-e3eac45f961d4bed9128d87b00d0adbc2023-11-21T18:03:33ZengMDPI AGMaterials1996-19442021-04-01149235110.3390/ma14092351Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion FunctionsZheng Su0Daye Sun1Li Zhang2Miaomiao He3Yulin Jiang4Bronagh Millar5Paula Douglas6Davide Mariotti7Paul Maguire8Dan Sun9Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, ChinaSchool of Mechanical & Aerospace Engineering, Queens University Belfast, Belfast BT9 5AH, UKResearch Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610065, ChinaResearch Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610065, ChinaResearch Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610065, ChinaSchool of Mechanical & Aerospace Engineering, Queens University Belfast, Belfast BT9 5AH, UKSchool of Mechanical & Aerospace Engineering, Queens University Belfast, Belfast BT9 5AH, UKNanotechnology and Integrated Bioengineering Center (NIBEC), Ulster University, Co Antrim BT37 OQB, UKNanotechnology and Integrated Bioengineering Center (NIBEC), Ulster University, Co Antrim BT37 OQB, UKSchool of Mechanical & Aerospace Engineering, Queens University Belfast, Belfast BT9 5AH, UKIn this work, we designed and fabricated a multifunctional nanocomposite system that consists of chitosan, raspberry-like silver nanoparticles, and graphene oxide. The room temperature atmospheric pressure microplasma (RT-APM) process provides a rapid, facile, and environmentally-friendly method for introducing silver nanoparticles into the composite system. Our composite can achieve a pH controlled single and/or dual drug release. Under pH 7.4 for methyl blue loaded on chitosan, the drug release profile features a burst release during the first 10 h, followed by a more stabilized release of 70–80% after 40–50 h. For fluorescein sodium loaded on graphene oxide, the drug release only reached 45% towards the end of 240 h. When the composite acted as a dual drug release system, the interaction of fluorescein sodium and methyl blue slowed down the methyl blue release rate. Under pH 4, both single and dual drug systems showed a much higher release rate. In addition, our composite system demonstrated strong antibacterial abilities against <i>E. coli</i> and <i>S. aureus</i>, as well as an excellent photothermal conversion effect under irradiation of near infrared lasers. The photothermal conversion efficiency can be controlled by the laser power. These unique functionalities of our nanocomposite point to its potential application in multiple areas, such as multimodal therapeutics in healthcare, water treatment, and anti-microbials, among others.https://www.mdpi.com/1996-1944/14/9/2351chitosansilver nanoparticlesgraphene oxidenanocompositesantibacterialdrug delivery |
| spellingShingle | Zheng Su Daye Sun Li Zhang Miaomiao He Yulin Jiang Bronagh Millar Paula Douglas Davide Mariotti Paul Maguire Dan Sun Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion Functions Materials chitosan silver nanoparticles graphene oxide nanocomposites antibacterial drug delivery |
| title | Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion Functions |
| title_full | Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion Functions |
| title_fullStr | Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion Functions |
| title_full_unstemmed | Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion Functions |
| title_short | Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion Functions |
| title_sort | chitosan silver nanoparticle graphene oxide nanocomposites with multi drug release antimicrobial and photothermal conversion functions |
| topic | chitosan silver nanoparticles graphene oxide nanocomposites antibacterial drug delivery |
| url | https://www.mdpi.com/1996-1944/14/9/2351 |
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