A polymorphic transcriptional regulatory domain in the amyotrophic lateral sclerosis risk gene CFAP410 correlates with differential isoform expression

A polymorphic transcriptional regulatory domain in the amyotrophic lateral sclerosis risk gene CFAP410 correlates with differential isoform expression

We describe the characterisation of a variable number tandem repeat (VNTR) domain within intron 1 of the amyotrophic lateral sclerosis (ALS) risk gene CFAP410 (Cilia and flagella associated protein 410) (previously known as C21orf2), providing insight into how this domain could support differential...

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Bibliographic Details
Main Authors: Jack N. G. Marshall, Alexander Fröhlich, Li Li, Abigail L. Pfaff, Ben Middlehurst, Thomas P. Spargo, Alfredo Iacoangeli, Bing Lang, Ammar Al-Chalabi, Sulev Koks, Vivien J. Bubb, John P. Quinn
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
CFAP410
ALS
VNTR
gene expression
transcriptional regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.954928/full

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