Relationship between baseline plasma p‐tau181 and longitudinal changes in cognition and structural brain measures in a cohort of cognitively unimpaired older adults
Abstract INTRODUCTION Preclinical Alzheimer's disease (AD) affects a significant proportion of cognitively unimpaired (CU) older adults. Currently, blood‐based biomarkers detect very early changes in the AD continuum with great accuracy. METHODS We measured baseline plasma phosphorylated tau (p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-10-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12487 |
| _version_ | 1797374395138703360 |
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| author | Marcos V. Pais Chia‐Ling Kuo Beau M. Ances Julie Loebach Wetherell Eric J. Lenze Breno S. Diniz |
| author_facet | Marcos V. Pais Chia‐Ling Kuo Beau M. Ances Julie Loebach Wetherell Eric J. Lenze Breno S. Diniz |
| author_sort | Marcos V. Pais |
| collection | DOAJ |
| description | Abstract INTRODUCTION Preclinical Alzheimer's disease (AD) affects a significant proportion of cognitively unimpaired (CU) older adults. Currently, blood‐based biomarkers detect very early changes in the AD continuum with great accuracy. METHODS We measured baseline plasma phosphorylated tau (p‐tau)181 using electrochemiluminescence (ECL)‐based assay (MesoScale Discovery) in 533 CU older adults. Follow‐up lasted up to 18 months. Cognitive performance assessment included memory and cognitive control. Structural brain measures included cortical thickness, which includes the AD magnetic resonance imaging (AD MRI) signature, and hippocampal volume. RESULTS In this cohort of CU older adults, baseline plasma p‐tau181 levels were not associated with short‐term changes in cognition and structural brain measures. Also, baseline plasma p‐tau levels did not influence the effects of behavioral interventions (exercise or mindfulness) on cognitive and structural brain changes. DISCUSSION The short follow‐up and healthy status of this CU cohort might have limited the sensitivity of plasma p‐tau181 in detecting changes associated with AD pathology. |
| first_indexed | 2024-03-08T19:05:11Z |
| format | Article |
| id | doaj.art-e3ec571cacf14274b3f5a6f87b24e35e |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-03-08T19:05:11Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-e3ec571cacf14274b3f5a6f87b24e35e2023-12-28T01:18:31ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292023-10-01154n/an/a10.1002/dad2.12487Relationship between baseline plasma p‐tau181 and longitudinal changes in cognition and structural brain measures in a cohort of cognitively unimpaired older adultsMarcos V. Pais0Chia‐Ling Kuo1Beau M. Ances2Julie Loebach Wetherell3Eric J. Lenze4Breno S. Diniz5UConn Center on Aging University of Connecticut Health Center Farmington Connecticut USADepartment of Public Health Sciences University of Connecticut Health Center Farmington Connecticut USADepartment of Neurology Washington University School of Medicine St. Louis Missouri USAVA San Diego Healthcare System and University of California San Diego San Diego California USAHealthy Mind Lab, Department of Psychiatry Washington University School of Medicine St. Louis Missouri USAUConn Center on Aging University of Connecticut Health Center Farmington Connecticut USAAbstract INTRODUCTION Preclinical Alzheimer's disease (AD) affects a significant proportion of cognitively unimpaired (CU) older adults. Currently, blood‐based biomarkers detect very early changes in the AD continuum with great accuracy. METHODS We measured baseline plasma phosphorylated tau (p‐tau)181 using electrochemiluminescence (ECL)‐based assay (MesoScale Discovery) in 533 CU older adults. Follow‐up lasted up to 18 months. Cognitive performance assessment included memory and cognitive control. Structural brain measures included cortical thickness, which includes the AD magnetic resonance imaging (AD MRI) signature, and hippocampal volume. RESULTS In this cohort of CU older adults, baseline plasma p‐tau181 levels were not associated with short‐term changes in cognition and structural brain measures. Also, baseline plasma p‐tau levels did not influence the effects of behavioral interventions (exercise or mindfulness) on cognitive and structural brain changes. DISCUSSION The short follow‐up and healthy status of this CU cohort might have limited the sensitivity of plasma p‐tau181 in detecting changes associated with AD pathology.https://doi.org/10.1002/dad2.12487Alzheimer's diseaseAlzheimer's disease magnetic resonance imaging signaturecortical thicknesshippocampal volumeplasma phosphorylated tau 181 |
| spellingShingle | Marcos V. Pais Chia‐Ling Kuo Beau M. Ances Julie Loebach Wetherell Eric J. Lenze Breno S. Diniz Relationship between baseline plasma p‐tau181 and longitudinal changes in cognition and structural brain measures in a cohort of cognitively unimpaired older adults Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease Alzheimer's disease magnetic resonance imaging signature cortical thickness hippocampal volume plasma phosphorylated tau 181 |
| title | Relationship between baseline plasma p‐tau181 and longitudinal changes in cognition and structural brain measures in a cohort of cognitively unimpaired older adults |
| title_full | Relationship between baseline plasma p‐tau181 and longitudinal changes in cognition and structural brain measures in a cohort of cognitively unimpaired older adults |
| title_fullStr | Relationship between baseline plasma p‐tau181 and longitudinal changes in cognition and structural brain measures in a cohort of cognitively unimpaired older adults |
| title_full_unstemmed | Relationship between baseline plasma p‐tau181 and longitudinal changes in cognition and structural brain measures in a cohort of cognitively unimpaired older adults |
| title_short | Relationship between baseline plasma p‐tau181 and longitudinal changes in cognition and structural brain measures in a cohort of cognitively unimpaired older adults |
| title_sort | relationship between baseline plasma p tau181 and longitudinal changes in cognition and structural brain measures in a cohort of cognitively unimpaired older adults |
| topic | Alzheimer's disease Alzheimer's disease magnetic resonance imaging signature cortical thickness hippocampal volume plasma phosphorylated tau 181 |
| url | https://doi.org/10.1002/dad2.12487 |
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