Evaluation of oxidative status in iron deficiency anemia through total antioxidant capacity measured using an automated method
OBJECTIVE: Oxidative stress, an increase in oxidants and/or a decrease in antioxidant capacity, is one of the potential biochemical mechanisms involved in the pathogenesis of iron deficiency anemia. The objective of this study was to evaluate the oxidative status and to determine whether there is an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2011-03-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-26213 |
| _version_ | 1797912465987600384 |
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| author | Mehmet Aslan Mehmet Horoz Hakim Çelik |
| author_facet | Mehmet Aslan Mehmet Horoz Hakim Çelik |
| author_sort | Mehmet Aslan |
| collection | DOAJ |
| description | OBJECTIVE: Oxidative stress, an increase in oxidants and/or a decrease in antioxidant capacity, is one of the potential biochemical mechanisms involved in the pathogenesis of iron deficiency anemia. The objective of this study was to evaluate the oxidative status and to determine whether there is any relationship between oxidative status and the severity of anemia in patients with iron deficiency anemia using an automated method. METHODS: Twenty-six subjects with iron deficiency anemia and 20 healthy controls were enrolled in the present study. Serum total antioxidant capacity, serum total peroxide level and oxidative stress index were determined in all study subjects. RESULTS: Serum total antioxidant capacity was significantly lower in patients with iron deficiency anemia than controls (p<0.05), while serum total peroxide level and oxidative stress index were significantly higher (both p<0.05). There was a significant correlation between hemoglobin level and serum total peroxide level, oxidative stress index and total antioxidant capacity (r=-0.504, p<0.05; r=-0.503, p<0.05; r=0.417, p<0.05, respectively). CONCLUSION: Increased oxidative stress may play a role in the pathogenesis of iron deficiency anemia. Supplementation of antioxidant vitamins in conjunction with iron replacement therapy may offer better responses and provide early resolution of symptoms related to iron deficiency anemia. The automated assay is a reliable and easily applied method for measurement of serum total antioxidant capacity in iron deficiency anemia. |
| first_indexed | 2024-04-10T11:56:24Z |
| format | Article |
| id | doaj.art-e3ed9c01cb0b480e9cd07ad4eac59ba5 |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T11:56:24Z |
| publishDate | 2011-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-e3ed9c01cb0b480e9cd07ad4eac59ba52023-02-15T16:16:48ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632011-03-01281424610.5152/tjh.2011.04TJH-26213Evaluation of oxidative status in iron deficiency anemia through total antioxidant capacity measured using an automated methodMehmet Aslan0Mehmet Horoz1Hakim Çelik2Department Of Internal Medicine Clinic, Özel Erciş Çapa Medicine Center, Van, TurkeyDepartment Of Internal Medicine, Faculty Of Medicine, Harran University, Şanlıurfa, TurkeyDepartment Of Clinical Biochemistry, Faculty Of Medicine, Harran University, Şanlıurfa, TurkeyOBJECTIVE: Oxidative stress, an increase in oxidants and/or a decrease in antioxidant capacity, is one of the potential biochemical mechanisms involved in the pathogenesis of iron deficiency anemia. The objective of this study was to evaluate the oxidative status and to determine whether there is any relationship between oxidative status and the severity of anemia in patients with iron deficiency anemia using an automated method. METHODS: Twenty-six subjects with iron deficiency anemia and 20 healthy controls were enrolled in the present study. Serum total antioxidant capacity, serum total peroxide level and oxidative stress index were determined in all study subjects. RESULTS: Serum total antioxidant capacity was significantly lower in patients with iron deficiency anemia than controls (p<0.05), while serum total peroxide level and oxidative stress index were significantly higher (both p<0.05). There was a significant correlation between hemoglobin level and serum total peroxide level, oxidative stress index and total antioxidant capacity (r=-0.504, p<0.05; r=-0.503, p<0.05; r=0.417, p<0.05, respectively). CONCLUSION: Increased oxidative stress may play a role in the pathogenesis of iron deficiency anemia. Supplementation of antioxidant vitamins in conjunction with iron replacement therapy may offer better responses and provide early resolution of symptoms related to iron deficiency anemia. The automated assay is a reliable and easily applied method for measurement of serum total antioxidant capacity in iron deficiency anemia.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-26213iron deficiency anemiatotal peroxidetotal antioxidant capacityoxidative stress |
| spellingShingle | Mehmet Aslan Mehmet Horoz Hakim Çelik Evaluation of oxidative status in iron deficiency anemia through total antioxidant capacity measured using an automated method Turkish Journal of Hematology iron deficiency anemia total peroxide total antioxidant capacity oxidative stress |
| title | Evaluation of oxidative status in iron deficiency anemia through total antioxidant capacity measured using an automated method |
| title_full | Evaluation of oxidative status in iron deficiency anemia through total antioxidant capacity measured using an automated method |
| title_fullStr | Evaluation of oxidative status in iron deficiency anemia through total antioxidant capacity measured using an automated method |
| title_full_unstemmed | Evaluation of oxidative status in iron deficiency anemia through total antioxidant capacity measured using an automated method |
| title_short | Evaluation of oxidative status in iron deficiency anemia through total antioxidant capacity measured using an automated method |
| title_sort | evaluation of oxidative status in iron deficiency anemia through total antioxidant capacity measured using an automated method |
| topic | iron deficiency anemia total peroxide total antioxidant capacity oxidative stress |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-26213 |
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